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Article
A microphysiological model of the bronchial airways reveals the interplay of mechanical and biochemical signals in bronchospasm
In asthma, the contraction of the airway smooth muscle and the subsequent decrease in airflow involve a poorly understood set of mechanical and biochemical events. Organ-level and molecular-scale models of the...
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Article
Open AccessRole of differentially expressed microRNA-139-5p in the regulation of phenotypic internal anal sphincter smooth muscle tone
The present study focused on the role of microRNA-139-5p (miRNA-139-5p) in the regulation of basal tone in internal anal sphincter (IAS). Applying genome-wide miRNA microarrays on the phenotypically distinct s...
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Article
Open AccessDefining an olfactory receptor function in airway smooth muscle cells
Pathways that control, or can be exploited to alter, the increase in airway smooth muscle (ASM) mass and cellular remodeling that occur in asthma are not well defined. Here we report the expression of odorant ...
