46 Result(s)
within
Hui-** Hsu
Life Sciences
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Article
Open AccessBrood success of sex-role-reversed pheasant-tailed jacanas: the effects of social polyandry, seasonality, and male mating order
Multiple mating by avian females may increase hatching and overall brood success; however, reproductive effort and parental investment are costly, and females may be gradually depleted, with lowered outputs ov...
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Open AccessThe in vitro and in vivo depigmentation activity of coenzyme Q0, a major quinone derivative from Antrodia camphorata, through autophagy induction in human melanocytes and keratinocytes
Coenzyme Q0 (CoQ0), a novel quinone derivative of Antrodia camphorata, has been utilized as a therapeutic agent (including antioxidant, anti-inflammatory, antiangiogenic, antiatherosclerotic, and anticancer agent...
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Soil Bacterial Communities Across Seven Rhizoma Peanut Cultivars (Arachis glabrata Benth.) Respond to Seasonal Variation
Soil microorganisms play key roles in soil nutrient transformations and have a notable effect on plant growth and health. Different plant genotypes can shape soil microbial patterns via the secretion of root e...
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Open AccessLoss of fragile WWOX gene leads to senescence escape and genome instability
Induction of DNA damage response (DDR) to ensure accurate duplication of genetic information is crucial for maintaining genome integrity during DNA replication. Cellular senescence is a DDR mechanism that prev...
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Neuroprotective Effects of Probiotic Lactobacillus reuteri GMNL-263 in the Hippocampus of Streptozotocin-Induced Diabetic Rats
Diabetes-related brain complications have been reported in clinical patients and experimental models. The objective of the present study was to investigate the neuroprotective mechanisms of Lactobacillus reuteri ...
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Effects of aqueous extract from Apostichopus japonicus on melanogenesis in B16F10 cells and zebrafish
Apostichopus japonicus is preserved in dried form after processing and used as food and traditional medicine. During the sea cucumber drying process, the boiled liquid is discarded as waste. In this study, the fr...
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Antigenicity and immunogenicity of chikungunya virus-like particles from mosquito cells
The spread of chikungunya virus (CHIKV) is reaching pandemic levels, and vaccines and antivirals to control CHIKV infection have yet to be approved. Virus-like particles (VLPs), a self-assembled native multi-s...
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Article
A symbiosis between Euploea butterflies and yeasts
Euploea butterflies harbor many yeast species on their mouthparts, legs, and wings. In this study, we focused on the distribution of two dominant yeast species, Candida corydali and Metschnikowia koreensis. We in...
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Open AccessMicroRNA-145-5p modulates Krüppel-like factor 5 and inhibits cell proliferation, migration, and invasion in nasopharyngeal carcinoma
In several human cancers, Krüppel-like factor 5 (KLF5), a zinc finger transcription factor, can contribute to both tumor progression or suppression; however, the precise role of KLF5 in nasopharyngeal carcinom...
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UHRF1: a novel metabolic guardian restricting AMPK activity
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Author Correction: SETDB1-mediated methylation of Akt promotes its K63-linked ubiquitination and activation leading to tumorigenesis
A Correction to this paper has been published: https://doi.org/10.1038/s41556-021-00686-x
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Open AccessSilencing of PhLA, a CIN-TCP gene, causes defected petal conical epidermal cell formation and results in reflexed corolla lobes in petunia
TCP-domain proteins, plant specific transcription factors, play important roles in various developmental processes. CIN-TCPs control leaf curvature in simple leaf species while regulate leaf complexity in comp...
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Open AccessOral administration of porcine epidemic diarrhea virus spike protein expressing in silkworm pupae failed to elicit immune responses in pigs
The silkworm (Bombyx mori) and its pupae have been used for decades as nutritional additives and applied on the production of high-quality recombinant proteins via the baculovirus expression vector (BEV) system. ...
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Open AccessCharacterization and identification of lysine glutarylation based on intrinsic interdependence between positions in the substrate sites
Glutarylation, the addition of a glutaryl group (five carbons) to a lysine residue of a protein molecule, is an important post-translational modification and plays a regulatory role in a variety of physiologic...
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Article
SETDB1-mediated methylation of Akt promotes its K63-linked ubiquitination and activation leading to tumorigenesis
The serine/threonine kinase Akt plays a central role in cell proliferation, survival and metabolism, and its hyperactivation is linked to cancer ...
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Article
Open AccessStout camphor tree genome fills gaps in understanding of flowering plant genome evolution
We present reference-quality genome assembly and annotation for the stout camphor tree (Cinnamomum kanehirae (Laurales, Lauraceae)), the first sequenced member of the Magnoliidae comprising four orders (Laurales,...
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Open AccessMDD-carb: a combinatorial model for the identification of protein carbonylation sites with substrate motifs
Carbonylation, which takes place through oxidation of reactive oxygen species (ROS) on specific residues, is an irreversibly oxidative modification of proteins. It has been reported that the carbonylation is r...
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Cell disruption of Chlorella vulgaris using active extracellular substances from Bacillus thuringiensis ITRI-G1 is a programmed cell death event
Microalgae are rich resources for high-value nutrients and biodiesel production. However, extraction of these valuable compounds from them requires costly energy-consuming procedures due to their rigid cell wa...
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Open AccessAn integrated approach with new strategies for QSAR models and lead optimization
Computational drug design approaches are important for shortening the time and reducing the cost for drug discovery and development. Among these methods, molecular docking and quantitative structure activity r...
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Article
Tamoxifen metabolite endoxifen interferes with the polyamine pathway in breast cancer
Tamoxifen is the most widely used drug to treat women with estrogen receptor α (ERα)-positive breast cancer. Endoxifen is recognized as the active metabolite of tamoxifen in humans. We studied endoxifen effect...
