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    Article

    Development of a high-pH reversed-phase well plate for peptide fractionation and deep proteome analysis of cells and exosomes

    The complexity of the proteome often limits the number of identified proteins in the nanoflow LC-MS (nanoLC-MS) analysis of samples. Therefore, peptide fractionation is essential for reducing the sample comple...

    Yu-Ching Liu, Yu-Ting Huang, Chao-Jung Chen in Analytical and Bioanalytical Chemistry (2022)

  2. Article

    Open Access

    Pleural cytokines MIF and MIP-3α as novel biomarkers for complicated parapneumonic effusions and empyema

    Patients with complicated parapneumonic effusion (CPPE)/empyema have high morbidity and mortality, particularly when adequate management is delayed. We aimed to investigate novel dysregulated cytokines that ca...

    Chia-Yu Yang, Yu-Hsuan Kuo, Min Chen, Chih-Liang Wang, Li-Jane Shih in Scientific Reports (2021)

  3. Article

    Open Access

    Combined serum biomarkers in the noninvasive diagnosis of complicated parapneumonic effusions and empyema

    We previously demonstrated that the pleural levels of proteins (neutrophil gelatinase-associated lipocalin/NGAL, calprotectin, bactericidal permeability-increasing/BPI, azurocidin 1/AZU-1) were valuable marker...

    Kuo-An Wu, Chih-Ching Wu, Yu-Ching Liu, Pei-Chun Hsueh in BMC Pulmonary Medicine (2019)

  4. Article

    Open Access

    Stout camphor tree genome fills gaps in understanding of flowering plant genome evolution

    We present reference-quality genome assembly and annotation for the stout camphor tree (Cinnamomum kanehirae (Laurales, Lauraceae)), the first sequenced member of the Magnoliidae comprising four orders (Laurales,...

    Shu-Miaw Chaw, Yu-Ching Liu, Yu-Wei Wu, Han-Yu Wang, Chan-Yi Ivy Lin in Nature Plants (2019)

  5. Article

    Open Access

    Proteome profiling reveals novel biomarkers to identify complicated parapneumonic effusions

    Patients with pneumonia and parapneumonic effusion (PPE) have elevated mortality and a poor prognosis. The aim of this study was to discover novel biomarkers to help distinguish between uncomplicated PPE (UPPE...

    Kuo-An Wu, Chih-Ching Wu, Chi-De Chen, Chi-Ming Chu, Li-Jane Shih in Scientific Reports (2017)