-
Article
Open AccessCharacterization and Identification of Lysine Succinylation Sites based on Deep Learning Method
Succinylation is a type of protein post-translational modification (PTM), which can play important roles in a variety of cellular processes. Due to an increasing number of site-specific succinylated peptides o...
-
Article
Open AccessIdentification of potential biomarkers related to glioma survival by gene expression profile analysis
Recent studies have proposed several gene signatures as biomarkers for different grades of gliomas from various perspectives. However, most of these genes can only be used appropriately for patients with speci...
-
Article
Open AccessCharacterization and identification of lysine glutarylation based on intrinsic interdependence between positions in the substrate sites
Glutarylation, the addition of a glutaryl group (five carbons) to a lysine residue of a protein molecule, is an important post-translational modification and plays a regulatory role in a variety of physiologic...
-
Article
Open AccessMDD-carb: a combinatorial model for the identification of protein carbonylation sites with substrate motifs
Carbonylation, which takes place through oxidation of reactive oxygen species (ROS) on specific residues, is an irreversibly oxidative modification of proteins. It has been reported that the carbonylation is r...
-
Article
Open AccessInvestigation and identification of functional post-translational modification sites associated with drug binding and protein-protein interactions
Protein post-translational modification (PTM) plays an essential role in various cellular processes that modulates the physical and chemical properties, folding, conformation, stability and activity of protein...
-
Article
Incorporating significant amino acid pairs and protein domains to predict RNA splicing-related proteins with functional roles
Machinery of pre-mRNA splicing is carried out through the interaction of RNA sequence elements and a variety of RNA splicing-related proteins (SRPs) (e.g. spliceosome and splicing factors). Alternative splici...
-
Article
Open AccessAn enhanced computational platform for investigating the roles of regulatory RNA and for identifying functional RNA motifs
Functional RNA molecules participate in numerous biological processes, ranging from gene regulation to protein synthesis. Analysis of functional RNA motifs and elements in RNA sequences can obtain useful infor...
-
Article
Open AccessGPMiner: an integrated system for mining combinatorial cis-regulatory elements in mammalian gene group
Sequence features in promoter regions are involved in regulating gene transcription initiation. Although numerous computational methods have been developed for predicting transcriptional start sites (TSSs) or ...
-
Article
Open AccessmiRTar: an integrated system for identifying miRNA-target interactions in human
MicroRNAs (miRNAs) are small non-coding RNA molecules that are ~22-nt-long sequences capable of suppressing protein synthesis. Previous research has suggested that miRNAs regulate 30% or more of the human prot...
-
Article
Open AccessA comprehensive resource for integrating and displaying protein post-translational modifications
Protein Post-Translational Modification (PTM) plays an essential role in cellular control mechanisms that adjust protein physical and chemical properties, folding, conformation, stability and activity, thus al...
