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Article
Open AccesscntTSP visualization technique for rotating blade surface flow at low Reynolds number
Research and development of aircraft with rotating wings at low Reynolds numbers have received much attention. This study proposes using a carbon nanotube temperature-sensitive paint (cntTSP) measurement techn...
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Article
Open AccessClustering method for time-series images using quantum-inspired digital annealer technology
Time-series clustering is a powerful data mining technique for time-series data in the absence of prior knowledge of the clusters. Here we propose a time-series clustering method that leverages an annealing ma...
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Article
Open AccessDosage compensation of Z sex chromosome genes in avian fibroblast cells
In birds, sex is genetically determined; however, the molecular mechanism is not well-understood. The avian Z sex chromosome (chrZ) lacks whole chromosome inactivation, in contrast to the mammalian chrX. To in...
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Article
Open AccessAuthor Correction: Regorafenib is suitable for advanced colorectal cancer patients who have previously received trifluridine/tipiracil plus bevacizumab
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Article
A Case of Tophaceous Pseudogout with Destruction of the Skull Base at the Temporomandibular Joint
We report a case of tophaceous pseudogout that occurred in the temporomandibular joint (TMJ) and presented with skull base destruction. The patient was a 73-year-old woman, who complained of an obstructed ear ...
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Article
Open AccessRegorafenib is suitable for advanced colorectal cancer patients who have previously received trifluridine/tipiracil plus bevacizumab
Regorafenib is a standard salvage line therapy used for advanced colorectal cancer (CRC). Recently, trifluridine/tipiracil (TFTD) plus bevacizumab also showed promising efficacy as a salvage line therapy for a...
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Article
Inflammatory prognostic factors in advanced or recurrent esophageal squamous cell carcinoma treated with nivolumab
In Japan, nivolumab administration is the standard treatment for patients with unresectable advanced or recurrent esophageal squamous cell carcinoma (ESCC) who are refractory or intolerant to fluoropyrimidines...
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Article
Open AccessClinical and prognostic features of patients with detailed RAS/BRAF-mutant colorectal cancer in Japan
RAS/BRAFV600E mutations are the most remarkable oncogenic driver mutations in colorectal cancer (CRC) and play an important role in treatment selection. No data are available regarding the clinical and prognostic...
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Article
Open AccessIsolation and Characterization of a Novel Phage SaGU1 that Infects Staphylococcus aureus Clinical Isolates from Patients with Atopic Dermatitis
The bacterium Staphylococcus aureus, which colonizes healthy human skin, may cause diseases, such as atopic dermatitis (AD). Treatment for such AD cases involves antibiotic use; however, alternate treatments are ...
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Article
Open AccessSegmental differences in Slc26a3-dependent Cl− absorption and HCO3− secretion in the mouse large intestine in vitro in Ussing chambers
The anion exchanger slc26a3 (DRA), which is mutated in congenital chloride-losing diarrhea, is expressed in the apical membrane of the cecum and middle-distal colon but not in the proximal colon of rodent larg...
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Protocol
Partial EMT/MET: An Army of One
As our understanding of Epithelial Mesenchymal Transition (EMT) increases, the original binary concept of E versus M no longer fits with experimental evidence. Re-definition of the EMT paradigm as spectral tra...
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Article
Open AccessStructural basis for effector protein recognition by the Dot/Icm Type IVB coupling protein complex
The Legionella pneumophila Dot/Icm type IVB secretion system (T4BSS) is extremely versatile, translocating ~300 effector proteins into host cells. This specialized secretion system employs the Dot/Icm type IVB co...
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Article
Open AccessClinical impact of low serum free T4 in patients with non-small cell lung cancer treated with nivolumab
Nivolumab improves the prognosis of non-small cell lung cancer (NSCLC) but can cause immune-related adverse events (irAEs). Reports have indicated longer progression-free survivals (PFSs) in patients with irAE...
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Protocol
Isolation of the Dot/Icm Type IV Secretion System Core Complex from Legionella pneumophila
Legionella utilizes specialized protein secretion machinery called the type IV secretion system encoded by dot/icm genes to modulate host cellular systems. We describe here the procedure to isolate the core compl...
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Article
Optimal management of immune-related adverse events resulting from treatment with immune checkpoint inhibitors: a review and update
Over the last two decades, molecular-targeted agents have become mainstream treatment for many types of malignancies and have improved the overall survival of patients. However, most patients eventually develo...
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Article
Efficacy and safety of retreatment with nivolumab in metastatic melanoma patients previously treated with nivolumab
Nivolumab is a monoclonal antibody directed against programmed death-1 that has been shown to improve survival in patients with metastatic melanoma. However, the efficacy of nivolumab and other agents in melan...
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Article
Open AccessClinical Impact of Single Nucleotide Polymorphism in PD-L1 on Response to Nivolumab for Advanced Non-Small-Cell Lung Cancer Patients
This study was intended to determine the efficacy of nivolumab, we evaluated treatment response with respect to PD-1/PD-L1 SNPs among patients with NSCLC. A total of 50 patients with NSCLC were treated with ni...
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Article
Open AccessBacterial secretion system skews the fate of Legionella-containing vacuoles towards LC3-associated phagocytosis
The evolutionarily conserved processes of endosome-lysosome maturation and macroautophagy are established mechanisms that limit survival of intracellular bacteria. Similarly, another emerging mechanism is LC3-...
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Chapter
Subversion of Host Membrane Dynamics by the Legionella Dot/Icm Type IV Secretion System
Legionella species are Gram-negative ubiquitous environmental bacteria, which thrive in biofilms and parasitize protozoa. Employing an evolutionarily conserved mechanism, the opportunistic pathogens also replicat...
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Article
Microbially cleaved immunoglobulins are sensed by the innate immune receptor LILRA2
Microbial proteases degrade a variety of host proteins1–3. However, it has remained largely unknown why microorganisms have evolved to acquire such proteases and how the host responds to microbially degraded prod...
