Co-signal Molecules in T Cell Activation
Immune Regulation in Health and Disease
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Hideo Yagita
Cancer Research
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Safety and antibody immune response of CHP-NY-ESO-1 vaccine combined with poly-ICLC in advanced or recurrent esophageal cancer patients
The nanoparticle complex of cholesteryl pullulan (CHP) and NY-ESO-1 antigen protein (CHP-NY-ESO-1) presents multiple epitope peptides to MHC class I and II pathways, leading to CD8+ and CD4+ T cell responses. Pol...
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Open AccessConcomitant targeting of programmed death-1 (PD-1) and CD137 improves the efficacy of radiotherapy in a mouse model of human BRAFV600-mutant melanoma
T cell checkpoint blockade with antibodies targeting programmed cell death (ligand)-1 (PD-1/PD-L1) and/or cytotoxic T lymphocyte-antigen 4 (CTLA-4) has improved therapy outcome in melanoma patients. However, ...
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Article
Notch controls the survival of memory CD4+ T cells by regulating glucose uptake
CD4+ T cells differentiate into memory T cells that protect the host from subsequent infection. In contrast, autoreactive memory CD4+ T cells harm the body by persisting in the tissues. The underlying pathways co...
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Influence of natural killer cells and perforin-mediated cytolysis on the development of chemically induced lung cancer in A/J mice
One alternative approach for the treatment of lung cancer might be the activation of the immune system using vaccination strategies. However, most of clinical vaccination trials for lung cancer did not reach t...
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Combined blockade of TIM-3 and TIM-4 augments cancer vaccine efficacy against established melanomas
Cancer vaccines have been developed to instruct the endogenous immune responses to autologous tumors and to generate durable clinical responses. However, the therapeutic benefits of cancer vaccines remain insu...
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Optimized combination therapy using bortezomib, TRAIL and TLR agonists in established breast tumors
TNF-related apoptosis-inducing ligand (TRAIL) is a member of the TNF family of cytokines, which can induce apoptosis in various tumor cells by engaging the receptors, DR4 and DR5. Bortezomib (Velcade) is a pro...
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Open AccessTranscriptome analyses of mouse and human mammary cell subpopulations reveal multiple conserved genes and pathways
Molecular characterization of the normal epithelial cell types that reside in the mammary gland is an important step toward understanding pathways that regulate self-renewal, lineage commitment, and differenti...
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Blockade of the Fas/Fas ligand interaction suppresses hepatocyte apoptosis in ischemia-reperfusion rat liver
Hepatic ischemia-reperfusion injury remains a significant problem for liver surgery, including transplantation, and apoptosis has been implicated in this type of hepatic injury. Here we found that through the ...
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Article
Critical link between TRAIL and CCL20 for the activation of TH2 cells and the expression of allergic airway disease
The role of tumor necrosis factor–related apoptosis-inducing ligand (TRAIL) in immune responses mediated by T-helper 2 (TH2) lymphocytes is unknown. Here we characterize the development of allergic airway disease...
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Article
Eradication of established tumors in mice by a combination antibody-based therapy
Tumor-cell apoptosis is the basis of many cancer therapies1,2,3, and tumor-specific T cells are the principal effectors of successful antitumor immunotherapies4,5,6,7. Here we show that induction of tumor-cell ap...
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A novel dendritic cell subset involved in tumor immunosurveillance
The interferon (IFN)-γ–induced TRAIL effector mechanism is a vital component of cancer immunosurveillance by natural killer (NK) cells in mice1,2. Here we show that the main source of IFN-γ is not the conventiona...
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Development of a whole cell vaccine for acute myeloid leukaemia
We describe the modification of tumour cells to enhance their capacity to act as antigen presenting cells with particular focus on the use of costimulatory molecules to do so. We have been involved in the gene...
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Open AccessProlonged AIDS-free Survival for SIV-infected Macaques Treated With Anti-FasL
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CD4+ T cells kill Id+ B-lymphoma cells: FasLigand-Fas interaction is dominant in vitro but is redundant in vivo
B-lymphoma cells express a highly tumor-specific antigen, monoclonal Ig, which is a promising target for immunotherapy. Previous work has demonstrated that B-lymphoma cells spontaneously process their endogeno...
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Article
T cells require TRAIL for optimal graft-versus-tumor activity
Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) is a member of the TNF superfamily that exhibits specific tumoricidal activity against a variety of tumors1,2. It is expressed on different ce...
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New aspects of natural-killer-cell surveillance and therapy of cancer
Summary
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Involvement of tumor necrosis factor-related apoptosis-inducing ligand in surveillance of tumor metastasis by liver natural killer cells
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) induces apoptosis in various tumor cells in vitro, but its physiological role in tumor surveillance remains unknown. Here, we report that TRAIL is c...
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Induction of antigen-specific immunosuppression by CD95L cDNA-transfected 'killer' dendritic cells
Dendritic cells (DCs) are special subsets of antigen-presenting cells characterized by their highly potent capacity to activate immunologically naive T cells. Here we report that DCs that are transfected with ...
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Preventing effect of anti-ICAM-1 and anti-LFA-1 monoclonal antibodies on murine islet allograft rejection
Immunosuppressive potentials of the blockade of intercellular adhesion molecule-1 (ICAM)-1/leukocyte function-associated antigen 1 (LFA-1) were examined in a murine islet allotransplantation model by using blo...
