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  1. No Access

    Article

    Inducing and exploiting vulnerabilities for the treatment of liver cancer

    Liver cancer remains difficult to treat, owing to a paucity of drugs that target critical dependencies1,2; broad-spectrum kinase inhibitors such as sorafenib provide only a modest benefit to patients with hepatoc...

    Cun Wang, Serena Vegna, Haojie **, Bente Benedict, Cor Lieftink… in Nature (2019)

  2. Article

    Open Access

    Concomitant targeting of programmed death-1 (PD-1) and CD137 improves the efficacy of radiotherapy in a mouse model of human BRAFV600-mutant melanoma

    T cell checkpoint blockade with antibodies targeting programmed cell death (ligand)-1 (PD-1/PD-L1) and/or cytotoxic T lymphocyte-antigen 4 (CTLA-4) has improved therapy outcome in melanoma patients. However, ...

    Paula Kroon, Jules Gadiot, Marlies Peeters… in Cancer Immunology, Immunotherapy (2016)

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  3. No Access

    Article

    Sunitinib pretreatment improves tumor-infiltrating lymphocyte expansion by reduction in intratumoral content of myeloid-derived suppressor cells in human renal cell carcinoma

    Targeted therapy with sunitinib, pazopanib or everolimus has improved treatment outcome for patients with metastatic renal cell carcinoma patients (RCC). However, despite considerable efforts in sequential or ...

    Aurelie Guislain, Jules Gadiot, Andrew Kaiser… in Cancer Immunology, Immunotherapy (2015)

  4. No Access

    Article

    Mimicking homeostatic proliferation in vitro generates T cells with high anti-tumor function in non-lymphopenic hosts

    CD8+ T cells undergoing homeostatic proliferation (HP) in a lymphopenic environment acquire a central memory-like phenotype (CD44+ CD62L+ Ly6c+). Such cells are readily functional in vitro, with a strong capacity...

    Andrew D. Kaiser, Jules Gadiot, Aurelie Guislain… in Cancer Immunology, Immunotherapy (2013)

  5. No Access

    Article

    High expression of GCLC is associated with malignant melanoma of low oxidative phenotype and predicts a better prognosis

    Reactive oxygen species (ROS) are strongly implicated in melanoma development, and treatment with antioxidants has shown efficacy in suppressing malignant transition and progression. Here, we investigated the ...

    Dimitrios Mougiakakos, Riki Okita, Takashi Ando… in Journal of Molecular Medicine (2012)

  6. No Access

    Article

    Insertional mutagenesis identifies multiple networks of cooperating genes driving intestinal tumorigenesis

    Douglas Winton and colleagues report the results of a large insertional mutagenesis screen to identify drivers of intestinal tumorigenesis in mice. The study identifies a large number of potential cancer drive...

    H Nikki March, Alistair G Rust, Nicholas A Wright, Jelle ten Hoeve… in Nature Genetics (2011)