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Article
Open AccessDevelopment of a composite hydrogel incorporating anti-inflammatory and osteoinductive nanoparticles for effective bone regeneration
Bone tissue regeneration is regulated by complex events, including inflammation, osteoinduction, and remodeling. Therefore, to induce the complete restoration of defective bone tissue, biomaterials with the ab...
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Article
Open AccessSecured delivery of basic fibroblast growth factor using human serum albumin-based protein nanoparticles for enhanced wound healing and regeneration
Basic fibroblast growth factor (bFGF) is one of the critical components accelerating angiogenesis and tissue regeneration by promoting the migration of dermal fibroblasts and endothelial cells associated with ...
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Article
Open AccessBiomimetic anti-inflammatory and osteogenic nanoparticles self-assembled with mineral ions and tannic acid for tissue engineering
Bone healing involves complex processes including inflammation, induction, and remodeling. In this context, anti-inflammatory and osteoconductive multi-functional nanoparticles have attracted considerable atte...
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Article
Open AccessBiomineralization of bone tissue: calcium phosphate-based inorganics in collagen fibrillar organic matrices
Bone regeneration research is currently ongoing in the scientific community. Materials approved for clinical use, and applied to patients, have been developed and produced. However, rather than directly affect...
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Article
Open AccessSize-controlled human adipose-derived stem cell spheroids hybridized with single-segmented nanofibers and their effect on viability and stem cell differentiation
Fabrication of three-dimensional stem cell spheroids have been studied to improve stem cell function, but the hypoxic core and limited penetration of nutrients and signaling cues to the interior of the spheroi...
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Article
Open AccessCurrent progress in application of polymeric nanofibers to tissue engineering
Tissue engineering uses a combination of cell biology, chemistry, and biomaterials to fabricate three dimensional (3D) tissues that mimic the architecture of extracellular matrix (ECM) comprising diverse inter...
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Article
Efficacy of mechanically modified electrospun poly(l-lactide-co-ε-caprolactone)/gelatin membrane on full-thickness wound healing in rats
Bioengineered skin substitute offers new opportunities for treating various skin ailments. To compensate the structural integrity problems of scaffolds prepared from natural components, we mechanically develop...
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Article
Fabrication of cell sheets with anisotropically aligned myotubes using thermally expandable micropatterned hydrogels
Although many efforts have been made to engineer cell sheets with anisotropic patterns, current techniques still exhibit several shortcomings including uncontrolled harvest time and deformation of pattern by c...
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Article
Effect of dual growth factor delivery using poly(lactic-co-glycolic acid) mesh on neovascularization in a mouse skin flap model
Skin flaps have the crucial issue that skin necrosis can occur due to tissue ischemia in the distal parts of flaps. To prevent tissue necrosis, skin flaps need to be supplied with sufficient blood perfusion th...
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Article
The incorporation of bFGF mediated by heparin into PCL/gelatin composite fiber meshes for guided bone regeneration
The concept of guided bone regeneration facilitated by barrier membranes has been widely considered to achieve enhanced bone healing in maxillofacial surgery. However, the currently available membranes are lim...
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Article
Erratum to: Control of Adhesion, focal adhesion assembly, and Differentiation of Myoblasts by Enzymatically Crosslinked Cell-Interactive Hydrogels
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Article
Control of adhesion, focal adhesion assembly, and differentiation of myoblasts by enzymatically crosslinked cell-interactive hydrogels
The development of an artificial matrix is critical as both a substrate to control the cell behavior and as a tool for examining the roles of cellular microenvironment in biology. This study developed cell-int...
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Article
Enhancement of cardiac myoblast responses onto electrospun PLCL fibrous matrices coated with polydopamine for gelatin immobilization
A variety of surface modification techniques have been proposed to improve the cell-biomaterial interactions. On the other hand, these processes may cleave long-chained polymers, and compromise their mechanica...
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Article
Development and characterization of nanofibrous poly(lactic-co-glycolic acid)/biphasic calcium phosphate composite scaffolds for enhanced osteogenic differentiation
Poly(lactic-co-glycolic acid)(PLGA)/biphasic calcium phosphate (BCP) composite nanofibers with different BCP to PLGA ratios were fabricated using the electrospinning technique. The scanning electron microscopy (S...
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Article
Surface modification of electrospun poly(L-lactide-co-ɛ-caprolactone) fibrous meshes with a RGD peptide for the control of adhesion, proliferation and differentiation of the preosteoblastic cells
Regulation of cell-material interactions is an important factor for modulating the cell function in many tissue engineering applications. A more attractive strategy for enhancing the cell-material interactions...
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Article
In vitro andin vivo characterization of a coronary stent coated with an elastic biodegradable polymer for the sustained release of paclitaxel
In conclusion, we developed a DES with PLCL and paclitaxel. After expansion with a balloon, there was no evidence of cracks or peelings in the PLCL/paclitaxel coated stent. Paclitaxel was releasedin vitro up to 9...
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Article
Tissue engineering using a cyclic strain bioreactor and gelatin/PLCL scaffolds
In this study, we demonstrate that cyclic strain increased the proliferation of HDFs and subsequent expression of ECM proteins. Specifically, HDFs engineered under the cyclic stretching exhibited higher prolif...
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Article
Preparation and characterization of temperature-sensitive poly(N-isopropylacrylamide)-g-poly(L-lactide-co-ε-caprolactone) nanofibers
Biodegradable and elastic poly(L-lactide-co-ε-caprolactone) (PLCL) was electrospun to prepare nanofibers, andN-isopropylacrylamide (NIPAAm) was then grafted onto their surfaces under aqueous conditions using60Co-...
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Article
The effect of a long-term cyclic strain on human dermal fibroblasts cultured in a bioreactor on chitosan-based scaffolds for the development of tissue engineered artificial dermis
Mechanical stimulation is known to activate several cellular signal transduction pathways, leading to the induction of signaling molecules and extracellular matrix (ECM) proteins, thereby modulating cellular a...
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Mathematical Simulation of Pressure Swing Adsorption Cycle with Pressure Equalization Step
A quantitative analysis of multi-bed PSA cycles with pressure equalization is undertaken by a mathematical simulation. Multi-bed cycles considered in this study are 2, 4, 5, and 10-bed cycles shown in patents....
