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N-acetylcysteine does not alter neurometabolite levels in non-treatment seeking adolescents who use alcohol heavily: A preliminary randomized clinical trial
Current treatments for adolescent alcohol use disorder (AUD) are mainly psychosocial and limited in their efficacy. As such, pharmacotherapies are being investigated as potential adjunctive treatments to bolst...
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Article
Open AccessGender bias perpetuation and mitigation in AI technologies: challenges and opportunities
Across the world, artificial intelligence (AI) technologies are being more widely employed in public sector decision-making and processes as a supposedly neutral and an efficient method for optimizing delivery...
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Small Bowel
This is a general review that will review relevant anatomy, pathology, clinical decision making, operative technique, postoperative complications and their management relevant to small bowel surgery. Relevant ...
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Pedagogical Implications of the New Information Environment
In response to new pedagogical challenges brought forth by the post-truth era, this chapter contextualizes what we call the new information environment with attention to various elements that compose this environ...
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Article
Scalable optical manufacture of dynamic structural colour in stretchable materials
Structurally coloured materials that change their colour in response to mechanical stimuli are uniquely suited for optical sensing and visual communication1–4. The main barrier to their widespread adoption is a l...
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Prognostic value of blood pressure in ambulatory heart failure: a meta-analysis and systematic review. Ambulatory blood pressure predicts heart failure prognosis
Previous primary studies have explored the association between blood pressure (BP) and mortality in ambulatory heart failure (HF) patients reporting varying and contrasting associations. The aim is to determin...
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Open AccessDevelopment and psychometric properties of surveys to assess provider perspectives on the barriers and facilitators of effective care transitions
The quality of the discharge process and effective care transitions between settings of care are critical to minimize gaps in patient care and reduce hospital readmissions. Few studies have explored which care...
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Article
Open AccessErratum to: nab-Paclitaxel Plus Gemcitabine Versus Gemcitabine in Patients with Metastatic Pancreatic Adenocarcinoma: Canadian Subgroup Analysis of the Phase 3 MPACT Trial
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Open AccessErratum: Second-line therapy after nab-paclitaxel plus gemcitabine or after gemcitabine for patients with metastatic pancreatic cancer
Correction to: British Journal of Cancer (2016) 115, 188–194. doi: 10.1038/bjc.2016.185; Published online 28 June 2016. Upon publication of the above paper in the British Journal of Cancer, the authors identif...
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Open AccessSecond-line therapy after nab-paclitaxel plus gemcitabine or after gemcitabine for patients with metastatic pancreatic cancer
This exploratory analysis evaluated second-line (2L) therapy for metastatic pancreatic cancer in a large phase 3 trial (MPACT).
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Open Accessnab-Paclitaxel Plus Gemcitabine Versus Gemcitabine in Patients with Metastatic Pancreatic Adenocarcinoma: Canadian Subgroup Analysis of the Phase 3 MPACT Trial
The phase III MPACT trial in patients with metastatic pancreatic cancer (MPC) demonstrated superior efficacy of nab-paclitaxel (nab-P) plus gemcitabine (Gem) compared with Gem monotherapy, including the primary e...
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Open AccessImmuno-oncology safety education experience: Key lessons from ipilimumab (IPI)
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Open AccessNew discovery rarely runs smooth: an update on progranulin/TNFR interactions
Progranulin (PGRN) is a growth factor implicated in various pathophysiological processes, including wound healing, inflammation, tumorigenesis, and neurodegeneration. It was previously reported that PGRN binds...
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Article
Maturation of the biotechnology industry changes job opportunities for scientists
The biotechnology industry has historically had a strong focus on innovation and research. As the industry has matured, companies have become intensely focused on commercialising their products. This study ass...
