19 Result(s)
within
Hao Guo
Internal Medicine
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Article
PCDH11X mutation as a potential biomarker for immune checkpoint therapies in lung adenocarcinoma
Immune checkpoint inhibitors (ICIs) have achieved impressive success in lung adenocarcinoma (LUAD). However, the response to ICIs varies among patients, and predictive biomarkers are urgently needed. PCDH11X is f...
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Article
Comparative efficacy and safety of six angiotensin II receptor blockers in hypertensive patients: a network meta-analysis
The antihypertensive effects of angiotensin II receptor blockers (ARBs) are well recognized. However, conventional meta-analyses have reported inconsistent results on their efficacy and safety.
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Article
Open AccessIntegrated analysis and validation of ferroptosis-related genes and immune infiltration in acute myocardial infarction
Acute myocardial infarction (AMI) is indeed a significant cause of mortality and morbidity in individuals with coronary heart disease. Ferroptosis, an iron-dependent cell death, is characterized by the accumul...
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Article
Targeting cytohesin-1 suppresses acute myeloid leukemia progression and overcomes resistance to ABT-199
Adhesion molecules play essential roles in the homeostatic regulation and malignant transformation of hematopoietic cells. The dysregulated expression of adhesion molecules in leukemic cells accelerates diseas...
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Article
Prediction of Fuhrman nuclear grade for clear cell renal carcinoma by a multi-information fusion model that incorporates CT-based features of tumor and serum tumor associated material
Prediction of Fuhrman nuclear grade is crucial for making informed herapeutic decisions in clear cell renal cell carcinoma (ccRCC). The current study aimed to develop a multi-information fusion model utilizing...
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Article
An alternative extension of telomeres related prognostic model to predict survival in lower grade glioma
The alternative extension of the telomeres (ALT) mechanism is activated in lower grade glioma (LGG), but the role of the ALT mechanism has not been well discussed. The primary purpose was to demonstrate the si...
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Article
SARS-CoV-2 Omicron BA.5.2-infection and COVID-19 in persons with chronic myeloid leukaemia
A SARS-CoV-2 Omicron (BA.5.2) epidemic began in China in December, 2022 following stop** the zero COVID policy.
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Article
Discovery and characterization of a novel cGAS covalent inhibitor for the treatment of inflammatory bowel disease
Cyclic GMP-AMP synthase (cGAS), a cytosolic DNA sensor, acts as a nucleotidyl transferase that catalyzes ATP and GTP to form cyclic GMP-AMP (cGAMP) and plays a critical role in innate immunity. Hyperactivation...
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Article
Open AccessApplication of machine learning in prediction of bone cement leakage during single-level thoracolumbar percutaneous vertebroplasty
In the elderly, osteoporotic vertebral compression fractures (OVCFs) of the thoracolumbar vertebra are common, and percutaneous vertebroplasty (PVP) is a common surgical method after fracture. Machine learning...
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Article
Effect of vitamin E supplementation in rheumatoid arthritis: a systematic review and meta-analysis
The purpose of this study was to evaluate the safety and effectiveness of vitamin E in rheumatoid arthritis patients.
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Article
Open AccessDevelopment and Validation of a Machine Learning-Based Nomogram for Prediction of Ankylosing Spondylitis
Ankylosing spondylitis (AS) is a chronic progressive inflammatory disease of the spine and its affiliated tissues. AS mainly affects the axial bone, sacroiliac joint, hip joint, spinal facet, and adjacent liga...
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Article
Correction to: LNC942 promoting METTL14-mediated m 6 A methylation in breast cancer cell proliferation and progression
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Article
LINC01021 maintains tumorigenicity by enhancing N6-methyladenosine reader IMP2 dependent stabilization of MSX1 and JARID2: implication in colorectal cancer
Insulin-like growth factor-2 mRNA-binding protein 2 (IGF2BP2, also known as IMP2), a novel class III N6-methyladenosine (m6A) reader, has recently gained attention due to its critical functions in recognizing and...
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Article
Open AccessBlood transfusion risk prediction in spinal tuberculosis surgery: development and assessment of a novel predictive nomogram
The present study attempted to predict blood transfusion risk in spinal tuberculosis surgery by using a novel predictive nomogram.
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Article
Open AccessUnusual erythematous plaque with white scales, a case of acquired syphilis in a child and literature review
Syphilis in children is uncommon with the mode of infection for this rare condition likely being congenital or acquired. While most acquired cases of syphilis in children result from sexual abuse, children can...
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Article
LNC942 promoting METTL14-mediated m6A methylation in breast cancer cell proliferation and progression
Increasing evidence supports that long noncoding RNAs (lncRNAs) act as master regulators involved in tumorigenesis and development at the N6-methyladenine (m6A) epigenetic modification level. However, the underly...
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Article
FDA-approved drug screen identifies proteasome as a synthetic lethal target in MYC-driven neuroblastoma
MYCN amplification in neuroblastoma predicts poor prognosis and resistance to therapy. Yet pharmacological strategies of direct MYC inhibition remain unsuccessful due to its “undruggable” protein structure. We he...
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Article
Forkhead box C1 promotes colorectal cancer metastasis through transactivating ITGA7 and FGFR4 expression
Metastatic colorectal cancer (CRC) is one of the most common causes of cancer death worldwide; however, the molecular mechanism underlying CRC metastasis remains unknown. Using an integrated approach, we ident...
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Article
Differential effects of short- and long-term bupivacaine treatment on α1-adrenoceptor-mediated contraction of isolated rat aorta rings and the reversal effect of lipid emulsion
Arterial function is significantly influenced by bupivacaine at both clinically relevant concentrations and toxic concentrations, but the underlying mechanisms are not fully understood. In the present study we...
