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Article
Open AccessImmune phenotypes and checkpoint molecule expression of clonally expanded lymph node-infiltrating T cells in classical Hodgkin lymphoma
Lymph node-infiltrating T cells have been of particular interest in classical Hodgkin lymphoma (cHL). High rates of complete therapeutic responses to antibody-mediated immune checkpoint blockade, even in relap...
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Article
Elucidating the principles of the molecular organization of heteropolymeric tight junction strands
Paracellular barrier properties of tissues are mainly determined by the composition of claudin heteropolymers. To analyze the molecular organization of tight junctions (TJ), we investigated the ability of clau...
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Article
Open AccessHistone acetylation controls the inactive X chromosome replication dynamics
In mammals, dosage compensation between male and female cells is achieved by inactivating one female X chromosome (**). Late replication of ** was proposed to be involved in the maintenance of its silenced sta...
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Article
Large-scale sorting of C. elegans embryos reveals the dynamics of small RNA expression
Fluorescence-activated cell sorting of worm embryos promises to replace manual sorting of staged embryos and yields large populations highly enriched in specific developmental stages, allowing high-throughput ...
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Article
Replication of centromeric heterochromatin in mouse fibroblasts takes place in early, middle, and late S phase
The replication of eukaryotic chromosomes takes place throughout S phase, but little is known how this process is organized in space and time. Early and late replicating chromosomal domains appear to localize ...
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Article
Biotechnological aspects of the production of human pro-kallikrein using the AcNPV-baculovirus-expression system
We have investigated large scale production processes (up to 2 liters) of recombinant proteins using the baculovirus expression system in order to optimize the product yields. Experiments using cell lines ofSpodo...
