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  1. No Access

    Chapter and Conference Paper

    Learning from the Past: Sequential Deep Learning for Gas Distribution Map**

    To better understand the dynamics in hazardous environments, gas distribution map** aims to map the gas concentration levels of a specified area precisely. Sampling is typically carried out in a spatially sp...

    Nicolas P. Winkler, Oleksandr Kotlyar in ROBOT2022: Fifth Iberian Robotics Conferen… (2023)

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    Article

    Increasing Long-Chain Dicarboxylic Acid Production in Candida tropicalis by Engineering Fatty Transporters

    Candida tropicalis can metabolize alkanes or fatty acids to produce long-chain dicarboxylic acids (DCAs). Fatty acid transporters located on the cell or peroxisome membrane may play an important role in this proc...

    Lihua Zhang, **ang **u, Zirui Wang, Yanjun Jiang, Han Fan in Molecular Biotechnology (2021)

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    Article

    Increasing l-lysine production in Corynebacterium glutamicum by engineering amino acid transporters

    Corynebacterium glutamicum has a long and successful history in the biotechnological production of l-lysine. Besides the adjustment of metabolic pathways, intracellular and extracellular transport systems are cri...

    **g **ao, Datao Wang, Lei Wang, Yanjun Jiang, Le Xue, Songsen Sui in Amino Acids (2020)

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    Article

    Enhancement of Production of d-Glucosamine in Escherichia coli by Blocking Three Pathways Involved in the Consumption of GlcN and GlcNAc

    d-Glucosamine is a commonly used dietary supplement that promotes cartilage health in humans. Metabolic flux analysis showed that d-glucosamine production could be increased by blocking three pathways involved in...

    Piwu Li, Xu Li, Zhao Wen, Ruizhen Dong, Kang Li, Han Fan in Molecular Biotechnology (2020)

  5. Article

    Open Access

    Emerging organoid models: lea** forward in cancer research

    Cancer heterogeneity is regarded as the main reason for the failure of conventional cancer therapy. The ability to reconstruct intra- and interpatient heterogeneity in cancer models is crucial for understandin...

    Han Fan, Utkan Demirci, Pu Chen in Journal of Hematology & Oncology (2019)

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    Article

    Construction and Application of Low Cellulase-producing Bacillus licheniformis Strains for Bio-pul** of Bamboo

    To prevent cellulose loss during bio-pul**, two cellulase genes in Bacillus licheniformis 20085 were knocked out by homologous exchange technique. An engineering strain B. licheniformis 20085Δcelb was significa...

    Le Xue, Haihong Han, Han Fan, Piwu Li in Biotechnology and Bioprocess Engineering (2019)

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    Article

    Development of mazF-based markerless genome editing system and metabolic pathway engineering in Candida tropicalis for producing long-chain dicarboxylic acids

    Candida tropicalis can grow with alkanes or plant oils as the sole carbon source, and its industrial application thus has great potential. However, the choice of a suitable genetic operating system can effectivel...

    Junqing Wang, Jian Peng, Han Fan, **ang **u in Journal of Industrial Microbiology & Biote… (2018)

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    Article

    Brain-Derived Neurotrophic Factor Contributes to Colonic Hypermotility in a Chronic Stress Rat Model

    Brain-derived neurotrophic factor (BDNF) has prokinetic effects on gut motility and is increased in the colonic mucosa of irritable bowel syndrome.

    **ao**g Quan, Hesheng Luo, Han Fan, Qincai Tang in Digestive Diseases and Sciences (2015)

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    Article

    Selective enzymatic preparation of vinyl sugar esters using DMSO as a denaturing co-solvent

    The protease-catalyzed transesterifications between hexoses and divinyladipate were examined. In dimethylformamide hexoses such as d-glucose, d-mannose, d-galactose and α-methyl d-galactoside were esterified w...

    Masaru Kitagawa, Han Fan, Takao Raku, Shigeo Shibatani in Biotechnology Letters (1999)