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Article
The protective effects of phosphoserine aminotransferase 1 (PSAT1) against hepatic ischemia–reperfusion injury
Hepatic ischemia–reperfusion (I/R) injury is a severe clinical syndrome, causing a profound medical and socioeconomic burden worldwide. This study aimed to explore underlying biomarkers and treatment targets ...
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Article
Effects and underlying mechanisms of L-arginine on spontaneous muscle contraction of rat colon
Arginine (Arg), as a basic amino acid, has been reported to be involved in regulation of gut motility. However, the evidence is limited and the underlying mechanism is not fully understood. Our study was condu...
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Article
KISS-1, Mediated by Promoter Methylation, Suppresses Esophageal Squamous Cell Carcinoma Metastasis via MMP2/9/MAPK Axis
KISS-1 is an established tumor suppressor that inhibits metastases in various malignancies. However, little is known regarding its role in esophageal squamous cell carcinoma (ESCC). The aim of the present stud...
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Article
CaMKII Mediates TGFβ1-Induced Fibroblasts Activation and Its Cross Talk with Colon Cancer Cells
Cancer-associated fibroblasts (CAFs), as the activated fibroblasts in tumor stroma, are important modifiers of tumor progression. TGFβ1 has been the mostly accepted factor to fuel normal fibroblasts transforma...
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Article
Open AccessDysfunction of apoptosis and autophagy correlates with local recurrence in esophageal squamous cell carcinoma after definitive chemoradiation
Definitive chemoradiotherapy (dCRT) is one of the standard treatments for esophageal squamous cell carcinoma (ESCC), but local recurrence is the main cause of treatment failure. The changes in apoptosis and au...
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Article
Clinical Efficacy of Single-Channel Gastroscopy, Double-Channel Gastroscopy, and Double Gastroscopy for Submucosal Tumors in the Cardia and Gastric Fundus
To determine the feasibility and efficacy of single-channel gastroscopy, double-channel gastroscopy, and double gastroscopy in treating submucosal tumors in the cardia and gastric fundus.
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Article
Open AccessOptogenetic engineering to probe the molecular choreography of STIM1-mediated cell signaling
Genetically encoded photoswitches have enabled spatial and temporal control of cellular events to achieve tailored functions in living cells, but their applications to probe the structure-function relations of...
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Article
Open AccessIntraluminal pressure patterns in the human colon assessed by high-resolution manometry
Assessment of colonic motor dysfunction is rarely done because of inadequate methodology and lack of knowledge about normal motor patterns. Here we report on elucidation of intraluminal pressure patterns using...
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Article
Open AccessMicroRNA-16 is putatively involved in the NF-κB pathway regulation in ulcerative colitis through adenosine A2a receptor (A2aAR) mRNA targeting
MicroRNAs (miRNAs) act as important post-transcriptional regulators of gene expression by targeting the 3′-untranslated region of their target genes. Altered expression of miR-16 is reported in human ulcerativ...
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Article
Brain-Derived Neurotrophic Factor Contributes to Colonic Hypermotility in a Chronic Stress Rat Model
Brain-derived neurotrophic factor (BDNF) has prokinetic effects on gut motility and is increased in the colonic mucosa of irritable bowel syndrome.
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Article
Open AccessChronic gastritis in China: a national multi-center survey
Chronic gastritis is one of the most common findings at upper endoscopy in the general population, and chronic atrophic gastritis is epidemiologically associated with the occurrence of gastric cancer. However,...
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Article
Intratumoral Heterogeneity Determines Discordant Results of Diagnostic Tests for Human Epidermal Growth Factor Receptor (HER) 2 in Gastric Cancer Specimens
Accurate assessment of human epidermal growth factor receptor (HER) 2 is essential for efficient selection of patients who may benefit from therapies targeting this surface receptor (e.g., trastuzumab). Intrat...
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Chapter and Conference Paper
Primo Vessels in the Mesentery of Nude Mice
Our previous studies have observed primo vessels in the mesentery of rats between the root of the mesentery and the colon or between the small intestine and the cecum. Some research revealed the involvement of...
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Article
Lipid disorders and lipid peroxidation associated with the malignant transformation of colorectal adenoma
The aim of this study was to investigate lipid disorders and lipid peroxidation associated with the malignant transformation of colorectal adenoma.
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Article
Overexpression of FADD enhances 5-fluorouracil-induced apoptosis in colorectal adenocarcinoma cells
To investigate the mechanism of enhancing apoptosis-inducing effects of 5-fluorouracil on human colorectal adenocarcinoma cells by stable transfection of extrinsic Fas-associated death domain protein (FADD) g...
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Article
The diagnosis of mesentery tumor
One hundred and seventy one patients with mesentery tumors confirmed by surgery and/or pathology in five hospitals of Hubei Province from 1966 to 1986 are analyzed retrospectively. The main manifestations were...
