-
Article
Genetic and clinical characteristics of acute B-cell lymphoblastic leukemia with MEF2D fusions and report of two novel MEF2D rearrangements
The MEF2D rearrangement is a recurrent chromosomal abnormality detected in approximately 2.4–5.3% of patients with acute B-cell lymphoblastic leukemia (B-ALL). Currently, MEF2D-rearranged B-ALL is not classified ...
-
Article
Dispel some mist on circulating biopterins: measurement, physiological interval and pathophysiological implication
Biopterins, including tetrahydrobiopterin (BH4), dihydrobiopterin (BH2), and biopterin (B), were crucial enzyme cofactors in vivo. Despite their recognized clinical significance, there remain notable research ...
-
Article
Open AccessDesigning Symmetric Gradient Honeycomb Structures with Carbon-Coated Iron-Based Composites for High-Efficiency Microwave Absorption
MIL-88C (Fe) with varying aspect ratios as a precursor was synthesized by regulating oil bath conditions, followed by one-step thermal decomposition to obtain carbon-coated iro...
-
Article
Salinity affects C/N ratio through differential responses of carbon and nitrogen metabolism in mangrove Avicennia marina leaves revealed by combined analysis of transcriptome and metabolome
Salt is a critical environmental factor that profoundly impacts plant growth and development. However, the investigation into how plants regulate carbon and nitrogen metabolism in response to different levels ...
-
Article
Design and prototy** of the readout electronics for the transition radiation detector in the high energy cosmic radiation detection facility
The high energy cosmic-radiation detection (HERD) facility is planned to launch in 2027 and scheduled to be installed on the China Space Station. It serves as a dark matter particle detector, a cosmic ray inst...
-
Article
Study on the optimal incident proton energy of 7Li(p, n)7Be neutron source for boron neutron capture therapy
Boron neutron capture therapy (BNCT) is recognized as a precise binary targeted radiotherapy technique that effectively eliminates tumors through the 10B(n,α)7Li nuclear reaction. Among various neutron sources, a...
-
Article
Open AccessIntegrative analyses of bulk and single-cell transcriptomics reveals the infiltration and crosstalk of cancer-associated fibroblasts as a novel predictor for prognosis and microenvironment remodeling in intrahepatic cholangiocarcinoma
Intrahepatic cholangiocarcinoma (ICC) is a highly malignant neoplasm and characterized by desmoplastic matrix. The heterogeneity and crosstalk of tumor microenvironment remain incompletely understood.
-
Article
Laparoscopic Left Hepatectomy for Intrahepatic Cholangiocarcinoma
Minimally invasive surgery for intrahepatic cholangiocarcinoma (ICC) remains challenging, especially in advanced patients.
-
Article
ASO Author Reflections: Laparoscopic Surgery for Intrahepatic Cholangiocarcinoma—Opportunities and Challenges
-
Article
Open AccessThe rise of baobab trees in Madagascar
The baobab trees (genus Adansonia) have attracted tremendous attention because of their striking shape and distinctive relationships with fauna1. These spectacular trees have also influenced human culture, inspir...
-
Article
Open AccessConservative versus liberal oxygen therapy for intensive care unit patients: meta-analysis of randomized controlled trials
It remains unclear whether conservative oxygen therapy (COT) or liberal oxygen therapy (LOT) is more beneficial to the clinical outcomes of intensive care unit (ICU) patients. We systematically reviewed the ef...
-
Article
Open AccessA paradigm shift in cancer research based on integrative multi-omics approaches: glutaminase serves as a pioneering cuproptosis-related gene in pan-cancer
Cuproptosis is a newly identified form of unprogrammed cell death. As a pivotal metabolic regulator, glutaminase (GLS) has recently been discovered to be linked to cuproptosis. Despite this discovery, the onco...
-
Article
The effect of lanthanum chloride on the electrocrystallization behavior of cobalt and grain refinement in deposition layers
This study investigates the effect of different concentrations of lanthanum chloride on the grain refinement of cobalt deposition layers during the electrochemical deposition process in industrial electrolytes...
-
Article
Open AccessVectorial liquid-crystal holography
Vectorial optics with fine inhomogeneous polarization control are highly desired. Metasurfaces have been captivated a promising candidate, but their static post-fabrication geometry largely limits the dynamic ...
-
Article
Open AccessCell-specific IL-1R1 regulates the regional heterogeneity of microglial displacement of GABAergic synapses and motor learning ability
Microglia regulate synaptic function in various ways, including the microglial displacement of the surrounding GABAergic synapses, which provides important neuroprotection from certain diseases. However, the p...
-
Article
Open AccessAge-, sex- and proximal–distal-resolved multi-omics identifies regulators of intestinal aging in non-human primates
The incidence of intestinal diseases increases with age, yet the mechanisms governing gut aging and its link to diseases, such as colorectal cancer (CRC), remain elusive. In this study, while considering age, ...
-
Article
Fangji Fuling Decoction Alleviates Sepsis by Blocking MAPK14/FOXO3A Signaling Pathway
To examine the therapeutic effect of Fangji Fuling Decoction (FFD) on sepsis through network pharmacological analysis combined with in vitro and in vivo experiments.
-
Article
Effect of cerium chloride on electric crystallization behavior and grain refinement of electrodeposited copper
Rare earth additives have an important influence on the quality of the deposited layer and the electric crystallization behavior during metal electrodeposition. In this paper, linear scanning voltammetry (LSV)...
-
Article
Einstein manifolds and curvature operator of the second kind
We prove that a compact Einstein manifold of dimension \(n\ge 4\) n ...
-
Article
Open AccessA deep learning system for predicting time to progression of diabetic retinopathy
Diabetic retinopathy (DR) is the leading cause of preventable blindness worldwide. The risk of DR progression is highly variable among different individuals, making it difficult to predict risk and personalize...
