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Article
Open AccessEstablishment of a circRNA-regulated E3 ubiquitin ligase signature and nomogram to predict immunotherapeutic efficacy and prognosis in hepatocellular carcinoma
Hepatocellular carcinoma (HCC) is a common type of malignant tumor where the prognosis is dismal. Circular RNA (CircRNA) is a novel RNA that regulates downstream gene transcription and translation to influence...
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Article
Temperature and humidity prediction of mountain highway tunnel entrance road surface based on improved Bi-LSTM neural network
As the temperature of mountain roads is low and the temperature difference between day and night is large, the change of road surface temperature and humidity will affect the road conditions. For example, cold...
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Article
A study of the relationship between social support, self-efficacy, professional identity, and willingness to practice medicine among medical students in the COVID-19 pandemic
This study aimed to investigate the relationship between social support, self-efficacy, professional identity, and willingness to practice medicine among medical students during the COVID-19 epidemic. An onlin...
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Article
Correction: Resistance to FGFR1-targeted therapy leads to autophagy via TAK1/AMPK activation in gastric cancer
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Article
Oncolytic mineralized bacteria as potent locally administered immunotherapeutics
Oncolytic bacteria can trigger innate immune activity. However, the antitumour efficacy of inactivated bacteria is poor, and attenuated live bacteria pose substantial safety risks. Here we show that intratumou...
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Article
Liposomal α-cyperone targeting bone resorption surfaces suppresses osteoclast differentiation and osteoporosis progression via the PI3K/Akt axis
Osteoporosis is a metabolic dysregulation of bone that occurs mainly in postmenopausal women, and the hyperfunction of osteoclasts is the primary contributor to postmenopausal osteoporosis. However, the develo...
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Article
TRIM5 as a promising diagnostic biomarker of hepatocellular carcinoma: integrated analysis and experimental validation
The TRIM family is associated with the membrane, and its involvement in the progression, growth, and development of various cancer types has been researched extensively. However, the role played by the TRIM5 g...
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Article
Deep reinforcement learning imbalanced credit risk of SMEs in supply chain finance
It is crucial to predict the credit risk of small and medium-sized enterprises (SMEs) accurately for the success of supply chain finance (SCF). However, most of the existing research ignore the fact that the d...
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Article
Evaluating the Safety of Using the Combined Mining Method in Close-Distance Coal Seams
This study aimed to investigate the internal dislocation law of coal seam working face under coal pillars with different widths and evaluate the safety of using the combined mining of close-distance coal seams...
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Article
Open AccessCorrection: Circular RNA circMET drives immunosuppression and anti-PD1 therapy resistance in hepatocellular carcinoma via the miR-30-5p/snail/DPP4 axis
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Article
Enhanced electrocaloric effect in Al2O3/P (VDF-TrFE-CTFE) nanocomposite: direct measurement by infrared thermal imaging
Poly (vinylidene fluoride)- based polymers have a relatively large electrocaloric effect (ECE) but low thermal conductivity. In some studies, the ECE obtained from indirect measurement deviates substantially f...
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Article
Surface Plasmon Filter Based on Metal–Insulator-Metal Waveguide with Multi-Stopband and High Filtering Efficiency
In order to meet the demand for multi-stopband filters and high filtering efficiency in optical nanodevices, a surface plasmon band-stop filter coupled with a straight waveguide and an arch-type resonator is p...
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Article
High-fidelity and robust optomechanical state transfer based on pulse control
The extended lifespan of mechanical oscillator enables its utilization as a reliable medium for information storage. Optomechanical system coupling the cavity mode with mechanical oscillator is a promising dev...
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Article
Novel spatial profiles of some diffusive SIS epidemic models
In this paper, we are concerned with two SIS epidemic reaction–diffusion models with mass action infection mechanism of the form SI, and study the spatial profile of population distribution as the movement rate o...
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Article
Open AccessWhat makes deceptive online reviews? A linguistic analysis perspective
With the rapid development of e-commerce, online reviews have become an important information source for consumers and e-commerce businesses. While the negative impact of deceptive online reviews has been well...
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Article
Open AccessDownregulation of mGluR1-mediated signaling underlying autistic-like core symptoms in Shank1 P1812L-knock-in mice
Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by core symptoms that consist of social deficits and repetitive behaviors. Unfortunately, no effective medication is available thus...
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Article
Associations between IGFBP1 gene polymorphisms and the risk of preeclampsia and fetal growth restriction
IGFBP1 plays a critical role in the pathogenesis of preeclampsia (PE), but the association between single nucleotide polymorphism (SNP) of IGFBP1 gene and PE susceptibility has not yet been determined. In our ...
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Article
Open AccessRNF173 suppresses RAF/MEK/ERK signaling to regulate invasion and metastasis via GRB2 ubiquitination in Hepatocellular Carcinoma
The role of the membrane-associated RING-CH (MARCH) family in carcinogenesis has been widely studied, but the member of this family, RNF173, has not yet been thoroughly explored in the context of hepatocellula...
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Article
Study on Meso-Fracture Behavior and Fractal Characteristics of Sandstone with Different Particle Sizes under Compression-Shear Test Conditions
In order to explore the micro-cracking behavior and fractal characteristics of sandstone with different particle sizes under the condition of compression-shear test, this paper studies sandstone with different...
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Article
Open AccessReassortment and genomic analysis of a G9P[8]-E2 rotavirus isolated in China
To isolate a prevalent G9P[8] group A rotavirus (RVA) (N4006) in China and investigate its genomic and evolutionary characteristics, with the goal of facilitating the development of a new rotavirus vaccine.
