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Article
Open AccessEarly-life exercise induces immunometabolic epigenetic modification enhancing anti-inflammatory immunity in middle-aged male mice
Exercise is usually regarded to have short-term beneficial effects on immune health. Here we show that early-life regular exercise exerts long-term beneficial effects on inflammatory immunity. Swimming trainin...
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Article
Switchable interfacial reaction enables bright and stable deep-red perovskite light-emitting diodes
High-performance deep-red light-emitting diodes (LEDs) are important for biomedical and agricultural applications. However, the development of bright and stable solution-processed deep-red LEDs remains challen...
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Article
Open AccessStarfysh integrates spatial transcriptomic and histologic data to reveal heterogeneous tumor–immune hubs
Spatially resolved gene expression profiling provides insight into tissue organization and cell–cell crosstalk; however, sequencing-based spatial transcriptomics (ST) lacks single-cell resolution. Current ST a...
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Article
Open AccessAge-, sex- and proximal–distal-resolved multi-omics identifies regulators of intestinal aging in non-human primates
The incidence of intestinal diseases increases with age, yet the mechanisms governing gut aging and its link to diseases, such as colorectal cancer (CRC), remain elusive. In this study, while considering age, ...
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Article
Open AccessAnomalous efficiency elevation of quantum-dot light-emitting diodes induced by operational degradation
Quantum-dot light-emitting diodes promise a new generation of high-performance and solution-processed electroluminescent light sources. Understanding the operational degradation mechanisms of quantum-dot light...
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Article
The Management and Antithrombotic Strategies of Patients with Coronary Artery Disease and High Bleeding Risk
In this review, we aim to summarize the current understanding of high bleeding risk (HBR) patients in coronary artery disease (CAD) and provide a comprehensive evaluation of the available antithrombotic strate...
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Article
Kindergarten Teachers’ Perceived Work Environment and the Teacher–Child Relationship: A Moderated Mediation Model
Guided by the conservation of resources model and risk-buffering model, this study examined whether teacher overwork mediates the association between the perceived work environment and the teacher–child relati...
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Chapter and Conference Paper
An Accurate Algorithm for Identifying Mutually Exclusive Patterns on Multiple Sets of Genomic Mutations
In cancer genomics, the mutually exclusive patterns of somatic mutations are important biomarkers that are suggested to be valuable in cancer diagnosis and treatment. However, detecting these patterns of mutat...
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Article
Multimodal single-cell and whole-genome sequencing of small, frozen clinical specimens
Single-cell genomics enables dissection of tumor heterogeneity and molecular underpinnings of drug response at an unprecedented resolution1–11. However, broad clinical application of these methods remains challen...
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Article
Microstructure evolution of high-strength and ultra-high-conductivity microfilament wire prepared by continuous deformation of single-crystal copper
The φ16 mm single-crystal copper rod billet was prepared by the heated mold horizontal continuous casting process. After cold drawing + 600 °C× 5 s annealing to φ1 mm, the annealed φ1 mm single-crystal copper pro...
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Article
Effect of annealing temperature on dual-structure coexisting precipitates in Cu–2.18Fe–0.03P alloy and softening mechanism at high temperature
The Cu–Fe–P alloy is the mainstream material of IC lead frame at present, which plays a key role in electrical signal transmission and mechanical fixation between bearing chip and external circuit board. With ...
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Article
Open AccessLncRNA FENDRR with m6A RNA methylation regulates hypoxia-induced pulmonary artery endothelial cell pyroptosis by mediating DRP1 DNA methylation
Pyroptosis is a form of programmed cell death involved in the pathophysiological progression of hypoxic pulmonary hypertension (HPH). Emerging evidence suggests that N6-methyladenosine (m6A)-modified transcrip...
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Article
Quantum-dot light-emitting diodes with Fermi-level pinning at the hole-injection/hole-transporting interfaces
Quantum-dot light-emitting diodes (QLEDs) are multilayer electroluminescent devices promising for next-generation display and solid-state-lighting technologies. In the state-of-the-art QLEDs, hole-injection la...
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Article
Particle Design and Inhalation Delivery of Iodine for Upper Respiratory Tract Infection Therapy
Diseases caused by upper respiratory tract (URT) and pulmonary infections have been a serious threat to human health for millennia and lack of targeted effective therapeutic techniques. In this study, two kind...
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Article
A Entity Relation Extraction Model with Enhanced Position Attention in Food Domain
Entity-relationship extraction is a fine-grained task for constructing a knowledge graph of food public opinion in the field of food public opinion, and it is also an important research topic in the field of c...
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Article
Open AccessCrystal structure and catalytic mechanism of the MbnBC holoenzyme required for methanobactin biosynthesis
Methanobactins (Mbns) are a family of copper-binding peptides involved in copper uptake by methanotrophs, and are potential therapeutic agents for treating diseases characterized by disordered copper accumulat...
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Article
Open AccessUbiquitinated AIF is a major mediator of hypoxia-induced mitochondrial dysfunction and pulmonary artery smooth muscle cell proliferation
Excessive proliferation of pulmonary artery smooth muscle cells (PASMCs) is the main cause of hypoxic pulmonary hypertension (PH), and mitochondrial homeostasis plays a crucial role. However, the specific mole...
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Article
Trimethylamine/Trimethylamine-N-Oxide as a Key Between Diet and Cardiovascular Diseases
Trimethylamine (TMA) is a gut microbiota-derived metabolite which comes from diets rich of choline, betaine or l-carnitine and could be further converted to Trimethylamine-N-oxide (TMAO) in the liver. As the func...
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Article
Effect of Impact Angle on the Critical Flow Velocity for Erosion–Corrosion of 304 Stainless Steel in Simulated Sand-Containing Sea Water
The critical flow velocity (CFV) is an important indicator to evaluate the erosion–corrosion performance of passive materials. The study focusing on the effect of impact angles on CFV behavior contributes to t...
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Article
Open AccessPoint-of-care detection, characterization, and removal of chocolate bloom using a handheld Raman spectrometer
Chocolate bloom is an off-white coating on the surface of chocolate products due to the altered distribution of the ingredients. Bloom reduces the shelf-life of chocolate and affects its visual and tactile qua...
