20 Result(s)

Chapter

Delivery System of Bioactive Molecules for Regenerative Medicine

It has been widely accepted that regenerative medicine as one part of nanomedicine offers an alternative technique to whole organ, tissue and cell transplantation for diseased, failed or malfunctioned body par...

Gilson Khang, Yoon Sun Jung, Soon Hee Kim, Moon Suk Kim… in NanoScience in Biomedicine (2009)

Chapter

Polymeric Nano Micelles as a Drug Carrier

Over recent decades there has been increasing interest in develo** drug delivery systems using polymeric micelles with nano size. Major challenges in drug delivery systems associated with nano micelles inclu...

Moon Suk Kim, Hyun Hoon, Gilson Khang, Hai Bang Lee in NanoScience in Biomedicine (2009)

Chapter and Conference Paper

Preparation of Sponge Using Porcine Small Intesinal Submucosa and Their Applications as a Scaffold and a Wound Dressing

Small intestine submucosa (SIS) derived from the submucosal layer of porcine intestine cause minimum immune response as acellular collagen based matrix1,2 and moreover is a biodegradable.3 SIS consists of types I...

Moon Suk Kim, Min Suk Lee, In Bum Song, Sang ** Lee, Hai Bang Lee… in Tissue Engineering (2007)

Chapter and Conference Paper

Evaluation of Various Types of Scaffold for Tissue Engineered Intervertebral Disc

Intervertebral discs (IVD) are specialized structures to anchor adjacent vertebral bodies conferring flexibility and providing mechanical stability during axial compression1. Degeneration of IVD results in discog...

Soon Hee Kim, Sun Jung Yoon, Bangsil Choi, Hyun Jung Ha, John M. Rhee… in Tissue Engineering (2007)

Article

Preparation of methoxy poly(ethyleneglycol)-block-poly(caprolactone) via activated monomer mechanism and examination of micellar characterization

The polymerization of ε–caprolactone (CL) in the presence of HCl·Et₂O via activated monomer mechanism was performed to synthesize diblock copolymers composed of methoxy polyethyleneglycol (MPEG) and poly(ε–caprol...

Moon Suk Kim, Hoon Hyun, Young Ho Cho, Kwang Su Seo, Woo Young Jang… in Polymer Bulletin (2005)

Article

Chondrogenic differentiation of bone marrow stromal cells in transforming growth factor-β₁ loaded alginate bead

We developed alginate beads loaded with transforming growth factor-β₁ (TGF-β₁) to examine the possible application of the scaffold and cytokine carrier in tissue engineering. In this study, bone marrow stromal ce...

Ki Suk Park, Chae Moon **, Soon Hee Kim, John M. Rhee… in Macromolecular Research (2005)

Article

Surface and chemical properties of surface-modified UHMWPE powder and mechanical and thermal properties of its impregnated PMMA bone cement V. Effect of silane coupling agent on the surface modification of UHMWPE powder

Conventional poly(methyl methacrylate)(PMMA) bone cement has been widely used as an useful biopolymeric material to fix bone using artificial prostheses. However, many patients had to be reoperated, due to the...

Dae Hyeok Yang, Goan Hee Yoon, Gyun Jeong Shin, Soon Hee Kim… in Macromolecular Research (2005)

Article

The effect of gamma irradiation on PLGA and release behavior of BCNU from PLGA wafer

The objectives of this study were to investigate the influence of gamma irradiation for sterilization on poly(D,L-lactide-co-glycolide) (PLGA) with different molecular weight and the effect of gamma irradiation o...

** Soo Lee, Gang Soo Chae, Gilson Khang, Moon Suk Kim… in Macromolecular Research (2003)

Article

Controlled release of nerve growth factor from sandwiched poly(L-lactide-co-glycolide) films for the application in neural tissue engineering

In order to fabricate new sustained delivery device of nerve growth factor (NGF), we developed NGFloaded biodegradable poly(L-lactide-co-glycolide) (PLGA, the mole ratio of lactide to glycolide 75∶25, molecular w...

Gilson Khang, Eun Kyung Jeon, John M. Rhee, Ilwoo Lee… in Macromolecular Research (2003)

Article

Local drug delivery system using biodegradable polymers

For last five years, we are develo** the novel local drug delivery devices using biodegradable polymers, especially polylactide (PLA) and poly(D,L-lactide-co-glycolide) (PLGA) due to its relatively good biocomp...

Gilson Khang, John M. Rhee, Je Kyo Jeong, Jeong Sik Lee… in Macromolecular Research (2003)

Article

Preparation of 5-fluorouracil-loaded poly(L-lactide-co-glycolide) wafer and evaluation ofin vitro release behavior

The controlled delivery of anticancer agents using biodegradable polymeric implant has been developed to solve the problem of penetration of blood brain barrier and severe systemic toxicity. This study was per...

** Soo Lee, Gang Soo Chae, Tae Kun An, Gilson Khang… in Macromolecular Research (2003)

Chapter

Preparation and Characterization of Natural/Synthetic Hybrid Scaffolds

It has been recognized that tissue engineering offers an alternative technique to whole organ and tissue transplantation for diseased, failed or malfunctioned organs. To reconstruct new tissues, cells which ar...

Gilson Khang, Sang ** Lee, Chang Whan Han… in Tissue Engineering, Stem Cells, and Gene T… (2003)

Article

Evaluation ofin vitro release profiles of fentanyl-loaded PLGA oligomer microspheres

In order to the development of the delivery device of long-acting local anesthetics for postoperative analgesia and control of chronic pain of cancer patient, fentanyl-loaded poly(l-lactide-co-glycolide)|(PLGA, m...

Gilson Khang, Sun-Ah Seo, Hak Soo Choi, John M. Rhee… in Macromolecular Research (2002)

Article

Preparation and characterization of small intestine submucosa powder impregnated poly(L-lactide) scaffolds: the application for tissue engineered bone and cartilage

In order to endow with new bioactive functionality from small intestine submucosa (SIS) powder as natural source to poly(L-lactide) (PLA) and poly(lactide-co-glycolide) (PLGA) synthetic biodegradable polymer, por...

Gilson Khang, John M. Rhee, Philkyung Shin, In Young Kim… in Macromolecular Research (2002)

Article

Effect of poly(3-hydroxybutyrate-co-3-hydroxyvalerate) surface with different wettability on fibroblast behavior

Poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) is a microbial storage polymer with biodegradable properties. In order to improve the cell compatibility of PHBV surfaces, the physicochemical treatments have b...

Sang ** Lee, Young Moo Lee, Gilson Khang, In Young Kim… in Macromolecular Research (2002)

Chapter

Blood Leak-Proof Porous Vascular Grafts

The design and fabrication of synthetic vascular prostheses have been a challenging area of vascular surgical research over the past 40 yr. Large-diameter, high-flow vascular replacements for use in the thorac...

** Ho Lee, Gilson Khang, Hai Bang Lee in Biomaterials Engineering and Devices: Huma… (2000)

Chapter

Cell Behavior on Polymer Surfaces with Different Functional Groups

Recently a large number of research groups have studied the interaction of biomedical materials with cultured cells because cell-compatible materials are thought to be very important to many biomedical applica...

** Ho Lee, ** Whan Lee, Gilson Khang… in Science and Technology of Polymers and Adv… (1998)

Chapter and Conference Paper

Gradient Surfaces as Tools to Study Biocompatibility

It is recognized that the behavior of the adsorption and desorption of blood proteins or the adhesion and proliferation of different types of mammalian cells on polymeric materials depend on the surface charac...

Hai Bang Lee, Bong ** Jeong, ** Ho Lee in Advanced Biomaterials in Biomedical Engine… (1996)

Chapter and Conference Paper

Cell Adhesion and Protein Adsorption on Gradient Surfaces

A new method for preparing a wettability gradient on polymer surfaces was developed. Low density polyethylene sheets were treated in air with corona from a knife-type electrode whose power gradually increases ...

Hai Bang Lee, ** Ho Lee in Progress in Pacific Polymer Science 3 (1994)

Article

Electric Current-Sensitive Drug Delivery Systems Using Sodium Alginate/Polyacrylic Acid Composites

Soon Hong Yuk, Sun Hang Cho, Hai Bang Lee in Pharmaceutical Research (1992)