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Article
Use of class I and class II HLA loci for predicting age at onset of type 1 diabetes in multiple populations
The study aimed to assess, in multiple populations, the role of HLA alleles on early and late age at onset of type 1 diabetes.
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Article
Open AccessConfirmation of novel type 1 diabetes risk loci in families
Over 50 regions of the genome have been associated with type 1 diabetes risk, mainly using large case/control collections. In a recent genome-wide association (GWA) study, 18 novel susceptibility loci were ide...
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Article
Pathway-based analysis of genetic susceptibility to cervical cancer in situ: HLA-DPB1 affects risk in Swedish women
We have conducted a pathway-based analysis of genome-wide single-nucleotide polymorphism (SNP) data in order to identify genetic susceptibility factors for cervical cancer in situ. Genotypes derived from Affymetr...
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Article
An update to HLA Nomenclature, 2010
The WHO Nomenclature Committee for Factors of the HLA System met during the 15th International Histocompatibility and Immunogenetics Workshop in Buzios, Brazil in September 2008. This update is an extract of t...
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Article
Evidence for association of the TCF7 locus with type I diabetes
The Type I Diabetes Genetics Consortium (T1DGC) has collected thousands of multiplex and simplex families with type I diabetes (T1D) with the goal of identifying genes involved in T1D susceptibility. These fam...
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Article
Association analysis of SNPs in the IL4R locus with type I diabetes
The Type I Diabetes Genetics Consortium (T1DGC) has collected thousands of multiplex and simplex families with type I diabetes (T1D) with the goal of identifying genes involved in T1D susceptibility. These fam...
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Article
MHC loci affecting cervical cancer risk: distinguishing the effects of HLA-DQB1 and non-HLA genes TNF, LTA, TAP1 and TAP2
Cervical cancer has been associated with specific human leukocyte antigen (HLA) haplotypes/alleles and with polymorphisms at the nearby non-HLA loci TNF, LTA, TAP1 and TAP2. Distinguishing effects of individual l...
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Article
Differential effects of DRB1*0301 and DQA1*0501-DQB1*0201 on the activation and progression of islet cell autoimmunity
Autoimmune diabetes shows extreme variation in age of onset and clinical presentation, although most studies have been done in children with the most severe subtype. Disease risk is strongly associated with HL...
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Article
The apolipoprotein A-IV Gln360His polymorphism predicts progression of coronary artery calcification in patients with type 1 diabetes
Individuals with type 1 diabetes have an increased incidence of coronary artery disease (CAD) and a higher risk of cardiovascular death compared with individuals of the same age in the general population. Whil...
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Article
Multifactor dimensionality reduction reveals gene–gene interactions associated with multiple sclerosis susceptibility in African Americans
Multiple sclerosis (MS) is a common disease of the central nervous system characterized by inflammation, myelin loss, gliosis, varying degrees of axonal pathology, and progressive neurological dysfunction. Mul...
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Article
Analysis of IL4R haplotypes in predisposition to multiple sclerosis
We have investigated the association of multiple sclerosis (MS) with polymorphisms in the IL4R gene in 332 single-case MS families. IL4R encodes a subunit of the interleukin-4 receptor, a molecule important for T...
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Chapter
The DQ Loci
The MHC class II DQ molecule is composed of an α-chain, encoded by the DQA1 locus and a β-chain, encoded by the DQB1 locus. In contrast to the DR and DP molecules, both the α-chain and the β-chain are polymorphic...
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Article
Newborn screening for HLA markers associated with IDDM: Diabetes Autoimmunity Study in the Young (DAISY)
Autoimmunity causing insulin-dependent diabetes mellitus (IDDM) begins in early childhood due to interactions between genes and unknown environmental factors that may be identified through follow-up of a large...
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Chapter and Conference Paper
Analysis by PCR/Oligonucleotide Ty** of HLA Class II Alleles in a Variety of Human Populations
The analysis of allele frequency distributions in various human populations can provide valuable anthropologic genetics information as well as useful data for forensics inferences about identity. One of the mo...
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Article
Nomenclature for factors of theHLA system, 1991
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Chapter and Conference Paper
Chairman’s Summing up Evolutionary Analysis of HLA Class II Polymorphisms
As I said earlier this morning, rather than use this time for summary of the very interesting talks we have heard, I thought I would very briefly go through some of the evolutionary analysis and just discuss h...
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Chapter and Conference Paper
Introduction
As you know in humans the general polymorphisms are HLA DR DQ and DP and perhaps one thing that we can think about — is there any different functions to these different alpha beta heterodimers. As you know, ma...
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Chapter and Conference Paper
Amplification of Y Chromosome-Specific Sequences in Biological Evidence
Determination of the sex of the donor of a biological evidence sample may be valuable in any investigation in which the identity of the donor is in question. The polymerase chain reaction (PCR) has been used t...
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Article
HLA and insulin-dependent diabetes mellitus
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Chapter
Analysis of HLA-DP Allelic Sequence Polymorphism Using the In Vitro Enzymatic Amplification of DPα and DPβ Loci
Accurate ty** of the HLA-DP antigens can provide useful information when considering allogeneic bone marrow transplantation. As with the HLA-DR and DQ antigens, the DP molecules may also play a role in susce...