-
Article
Open AccessA consensus-based framework for conducting and reporting osteoarthritis phenotype research
The concept of osteoarthritis (OA) heterogeneity is evolving and gaining renewed interest. According to this concept, distinct subtypes of OA need to be defined that will likely require recognition in research...
-
Article
Open AccessKnee pain and related health in the community study (KPIC): a cohort study protocol
The incidence, progression and related risk factors for recent-onset knee pain (KP) remain uncertain. This study aims to examine the natural history of KP including incidence and progression and to identify po...
-
Article
Open AccessGut microbiome diversity and high-fibre intake are related to lower long-term weight gain
Cross-sectional studies suggest that the microbes in the human gut have a role in obesity by influencing the human body’s ability to extract and store calories. The aim of this study was to assess if there is ...
-
Article
Open AccessUntangling the relationship between diet and visceral fat mass through blood metabolomics and gut microbiome profiling
Higher visceral fat mass (VFM) is associated with an increased risk for develo** cardio-metabolic diseases. The mechanisms by which an unhealthy diet pattern may influence visceral fat (VF) development has y...
-
Article
Open AccessKIR haplotypes are associated with late-onset type 1 diabetes in European–American families
Classical human leukocyte antigens (HLA) genes confer the strongest, but not the only, genetic susceptibility to type 1 diabetes. Killer cell immunoglobulin-like receptors (KIR), on natural killer (NK) cells, ...
-
Article
Use of class I and class II HLA loci for predicting age at onset of type 1 diabetes in multiple populations
The study aimed to assess, in multiple populations, the role of HLA alleles on early and late age at onset of type 1 diabetes.
-
Article
Genetic variation within the HLA class III influences T1D susceptibility conferred by high-risk HLA haplotypes
Human leukocyte antigen (HLA) class II DRB1 and DQB1 represent the major type I diabetes (T1D) genetic susceptibility loci; however, other genes in the HLA region are also involved in T1D risk. We analyzed 1411 p...
-
Article
Evidence for association of the TCF7 locus with type I diabetes
The Type I Diabetes Genetics Consortium (T1DGC) has collected thousands of multiplex and simplex families with type I diabetes (T1D) with the goal of identifying genes involved in T1D susceptibility. These fam...
-
Article
Association analysis of SNPs in the IL4R locus with type I diabetes
The Type I Diabetes Genetics Consortium (T1DGC) has collected thousands of multiplex and simplex families with type I diabetes (T1D) with the goal of identifying genes involved in T1D susceptibility. These fam...
-
Article
Natural history and risk factors for bone loss in postmenopausal Caucasian women: a 15-year follow-up population-based study
In this 15-year follow-up study, we found that the estimated rate of bone loss at the femoral neck (FN) for women aged 45–68 was linear at a rate of 1.67% per year, but quadratic for lumbar spine (LS) at a rat...
-
Article
Telomere length in leukocytes correlates with bone mineral density and is shorter in women with osteoporosis
Telomere length decreases with age and is associated with osteoblast senescence. In 2,150 unselected women, leukocyte telomere length was significantly correlated with bone mineral density. Clinical osteoporos...
-
Article
D6S265*15 marks a DRB1*15, DQB1*0602 haplotype associated with attenuated protection from type 1 diabetes mellitus
The HLA class II DQB1*0602 allele confers strong dominant protection against type 1 diabetes but protection is not absolute. The aim of this study was to identify markers within the HLA region that differentiate
-
Article
Dopamine receptor DRD2 genotype and smoking cessation outcome following treatment with bupropion SR
The A1 allele of the dopamine D2 receptor gene (DRD2) is associated with a reduced number of dopamine binding sites in the brain and with the increased likelihood of substance abuse and addictive behavior. In a s...
-
Article
The HLA-DR2 haplotype is associated with an increased proliferative response to the immunodominant CD4+ T-cell epitope in human interferon-β
Human CD4+ T-cell epitopes were identified in interferon-beta (IFN-β)-1b. A prominent peptide epitope region was found that induced a proliferative response in 16% of all donors tested. Responses corresponded to ...
