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Article
Response-adapted consolidation with bortezomib after ASCT improves progression-free survival in newly diagnosed multiple myeloma
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Article
Allogeneic hematopoietic SCT in patients with AML following treosulfan/fludarabine conditioning
An alternative reduced-toxicity conditioning regimen for allogeneic transplantation, based on treosulfan and fludarabine, has recently been identified. The safety and efficacy of this new conditioning regimen ...
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Article
A prospective randomized controlled trial comparing PCR-based and empirical treatment with liposomal amphotericin B in patients after allo-SCT
We compared the efficacy and safety of empirical plus PCR-based vs empirical liposomal amphotericin B treatment after Allo-SCT. Allo-SCT recipients were randomized to receive either PCR-based preemptive therap...
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Article
The addition of rituximab to front-line therapy with CHOP (R-CHOP) results in a higher response rate and longer time to treatment failure in patients with lymphoplasmacytic lymphoma: results of a randomized trial of the German Low-Grade Lymphoma Study Group (GLSG)
Lymphoplasmacytic lymphoma (LPL) is an indolent lymphoma with moderate sensitivity to conventional chemotherapy. This study investigated whether the addition of rituximab to standard chemotherapy improves trea...
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Article
AML1–ETO meets JAK2: clinical evidence for the two hit model of leukemogenesis from a myeloproliferative syndrome progressing to acute myeloid leukemia
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Article
A therapeutic platelet transfusion strategy is safe and feasible in patients after autologous peripheral blood stem cell transplantation
Prophylactic platelet transfusions are considered as standard in most hematology centers, but there is a long-standing controversy as to whether standard prophylactic platelet transfusions are necessary or whe...
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Article
Extramedullary relapse in acute promyelocytic leukemia treated with all-trans retinoic acid and chemotherapy
We analyzed the incidence, presenting features, risk factors of extramedullary (EM) relapse occurring in acute promyelocytic leukemia (APL) treated with all-trans retinoic acid (ATRA) and chemotherapy by using a ...
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Article
High-dose chemotherapy with autologous haemopoietic support for advanced ovarian cancer in first complete remission: retrospective analysis from the Solid Tumour Registry of the European Group for Blood and Marrow Transplantation (EBMT)
The majority of advanced ovarian cancer patients achieve an objective response following chemotherapy; however, only 20–30% are in remission after 5 years. Intraperitoneal or high-dose chemotherapy (HDC) may p...
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Article
First-line high-dose chemotherapy for patients with poor prognosis extragonadal germ cell tumors: the experience of the European Bone Marrow Transplantation (EBMT) Solid Tumors Working Party
Extragonadal germ cell tumors are classified according to the staging system of the International Germ Cell Cancer Collaborative Group (IGCCCG). The 5-year overall and disease-free survival rates for poor prog...
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Article
Secondary acute leukemia following mitoxantrone-based high-dose chemotherapy for primary breast cancer patients
The incidence of secondary myelodysplasia/acute myeloid leukemia (AML) was retrospectively assessed in an international joint study in 305 node-positive breast cancer patients, who received mitoxantrone-based ...
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Article
Allogeneic stem cell transplantation after a fludarabine/busulfan-based reduced-intensity conditioning in patients with myelodysplastic syndrome or secondary acute myeloid leukemia
We report the feasibility and efficacy of a fludarabine/busulfan-based dose-reduced conditioning regimen followed by stem cell transplantation from related (n=19) or unrelated HLA-matched donors (n=18) in 37 pati...
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Chapter and Conference Paper
Total Marrow Irradiation (TMI), Busulfan, and Cyclophosphamide for Allografting in Multiple Myeloma. A Pilot Study
To reduce the incidence of severe graft versus host disease (GvHD) and lower the treatment related mortality(TRM) in allogeneic stem cell transplantation from HLA-identical siblings patients with multiple myel...
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Article
Nonmyeloablative stem cell transplantation in adults with high-risk ALL may be effective in early but not in advanced disease
The feasibility of nonmyeloablative stem cell transplantation (NST) was evaluated in 22 adults with high-risk ALL. 16/22 patients had advanced disease and 11/22 had Ph+ ALL. Eleven patients received NST as fir...
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Article
Genotypically nonidentical related donors for transplantation of patients with myelodysplastic syndromes: comparison with unrelated donor transplantation and autologous stem cell transplantation
Transplantation with histocompatible identical siblings is a curative treatment for patients with myelodysplastic syndromes (MDS). Alternative treatments, such as transplantation with other family donors, are ...
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Chapter and Conference Paper
The 10.000/μl Morning Trigger for Prophylactic Platelet Transfusion is Safe: Prospective Experience in 411 AML Patients
There is an increasing demand for platelet transfusions and it remains an ongoing challenge for most blood centers to maintain an adequate platelet inventory. Platelet transfusions doubled in the US and in Can...
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Article
Long-term follow-up confirms the benefit of all-trans retinoic acid in acute promyelocytic leukemia
First results of a randomized trial (APL91 trial) and other randomized or non-randomized studies have shown that ATRA followed by chemotherapy significantly increased event-free survival (EFS) and survival, an...
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Article
Sequential cycles of high-dose chemotherapy with dose escalation of carboplatin with or without paclitaxel supported by G-CSF mobilized peripheral blood progenitor cells: a phase I/II study in advanced ovarian cancer
To assess high-dose carboplatin chemotherapy with or without paclitaxel with filgrastim mobilized peripheral blood progenitor cell (PBPC) support in a phase I/II study, a total of 21 patients with mostly chemo...
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Chapter and Conference Paper
Long-term Follow Up of a Prospective Multicenter Trial with a High-Dose Cytosine Arabinoside and Daunorubicin Postremission Therapy in Adults with De Novo Acute Myeloid Leukemia
A total of 149 consecutive de novo acute myeloid leukemia (AML) patients aged 50 years or less (median age = 37 years) were enrolled in this prospective multicenter trial initiated in May 1985. All patients re...
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Chapter and Conference Paper
The 10/NL Trigger for Prophylactic Platelet Transfusion in Acute Myeloid Leukemia: A Prospective Comparative Multicenter Study
This study shows that the 10/nl trigger for prophylactic platelet transfusion according to the inclusion criteria of our transfusion protocol is as safe as the traditional platelet transfusion threshold of 20/...
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Article
Aerosol amphotericin B inhalations for prevention of invasive pulmonary aspergillosis in neutropenic cancer patients
To determine the value of aerosol amphotericin B inhalations for prevention of invasive pulmonary aspergillosis (IPA), we initiated a prospective randomized multicenter trial. The scheduled intent-to-treat int...