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Safety and efficacy of the anti-PD1 immunotherapy with nivolumab in trichoblastic carcinomas
Trichoblastic carcinoma is a rare malignant cutaneous adnexal tumor with a risk of local invasion and distant metastasis. As of today, there is no consensus for the treatment of locally advanced or metastatic ...
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Article
Open AccessThe appropriate and sequential value of standard radiograph, computed tomography and magnetic resonance imaging to characterize a bone tumor
Radiographs (XR), computed tomography (CT) or magnetic resonance imaging (MRI) are regularly analyzed to determine whether a bone lesion is benign or malignant. An online quiz was created providing 15 cases wi...
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Article
Open AccessDetermination of the ED95 of intrathecal hyperbaric prilocaine with sufentanil for scheduled cesarean delivery: a dose-finding study based on the continual reassessment method
Scheduled cesarean section is routinely performed under spinal anesthesia using hyperbaric bupivacaine. The current study was undertaken to determine the clinically relevant 95% effective dose of intrathecal 2...
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Intensive care medicine in 2050: clinical trials designs
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Article
Lenalidomide-mediated erythroid improvement in non-del(5q) myelodysplastic syndromes is associated with bone marrow immuno-remodeling
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Clinical impact of NK-cell reconstitution after reduced intensity conditioned unrelated cord blood transplantation in patients with acute myeloid leukemia: analysis of a prospective phase II multicenter trial on behalf of the Société Française de Greffe de Moelle Osseuse et Thérapie Cellulaire and Eurocord
Unrelated cord blood transplantation (UCBT) after a reduced intensity conditioning regimen (RIC) has extended the use of UCB in elderly patients and those with co-morbidities without an HLA-identical donor, al...
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Article
Monitoring antimicrobial resistance (AMR) using CUSUM control charts
We evaluated the use of the Cumulative Summation (CUSUM) control chart methodology for detection of an excessive increase in antimicrobial-resistant (AMR) bacteria acquisition. We used administrative, clinical...
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Open AccessESICM LIVES 2016: part three
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Open AccessESICM LIVES 2016: part two
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Lenalidomide with or without erythropoietin in transfusion-dependent erythropoiesis-stimulating agent-refractory lower-risk MDS without 5q deletion
After failure of erythropoiesis-stimulating agents (ESAs), lenalidomide (LEN) yields red blood cell (RBC) transfusion independence (TI) in 20–30% of lower-risk non-del5q myelodysplastic syndrome (MDS). Several...
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Article
Changes in intensive care for allogeneic hematopoietic stem cell transplant recipients
Intensive care unit (ICU) admission is associated with high mortality in allogeneic hematopoietic stem cell transplant (HSCT) recipients. Whether mortality has decreased recently is unknown. The 497 adult allo...
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Article
Multiple imputation: a mature approach to dealing with missing data
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Article
Prognosis of neutropenic patients admitted to the intensive care unit
The prognosis of critically ill cancer patients has improved recently. Controversies remain as regard to the specific prognosis impact of neutropenia in critically ill cancer patients. The primary objective of...
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Article
Bronchiolitis obliterans syndrome after allogeneic hematopoietic SCT: phenotypes and prognosis
Bronchiolitis obliterans syndrome (BOS) after allogeneic hematopoietic SCT (HSCT) is recognized as a new-onset obstructive lung defect (OLD) in pulmonary function testing and is related to pulmonary chronic GV...
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Open AccessPrevalence, risk factors and impact of severe burnout syndrome in 12 Uruguayan ICUs
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Time course of organ failure in patients with septic shock treated with hydrocortisone: results of the Corticus study
Introduction: Corticosteroids have been proposed to decrease morbidity and mortality in patients with septic shock. An impact on morbidity should be anticipated to be earlier and more easily detect...
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Time course of organ failure in patients with septic shock treated with hydrocortisone: results of the Corticus study
Corticosteroids have been proposed to decrease morbidity and mortality in patients with septic shock. An impact on morbidity should be anticipated to be earlier and more easily detected than the impact on mort...
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Tandem autologous non-myeloablative allogeneic transplantation in patients with multiple myeloma relapsing after a first high dose therapy
We retrospectively studied a series of 23 patients (median age 50 years, range 29–59 years) with multiple myeloma (MM), treated in first relapse by a sequential autologous–allogeneic tandem approach. Tandem tr...
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Hematopoietic progenitor cell mobilization and harvesting in children with malignancies: do the advantages of pegfilgrastim really translate into clinical benefit?
Our purpose was to assess success rates in children of achieving optimal hematopoietic progenitor cells (HPCs) harvest after mobilization with 300 μg/kg pegfilgrastim. Between January 2005 and January 2007, 26...
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Article
Combined inhaled steroids and bronchodilatators in obstructive airway disease after allogeneic stem cell transplantation
Bronchiolitis obliterans (BO) is a potentially life-threatening complication following allogeneic stem cell transplantation (SCT) and usually carries a poor prognosis. Immunosuppressive medications are the mai...