12 Result(s)

Article

TaqTth-hpRNA: a novel compact RNA-targeting tool for specific silencing of pathogenic mRNA

Pathogenic allele silencing is a promising treatment for genetic hereditary diseases. Here, we develop an RNA-cleaving tool, TaqTth-hpRNA, consisting of a small, chimeric TaqTth, and a hairpin RNA guiding prob...

Chong Xu, Jiyanuo Cao, Huanran Qiang, Yu Liu, Jialin Wu, Qiudan Luo… in Genome Biology (2024)

Article

Tyrosine-kinase inhibitor combined with iodine-125 seed brachytherapy for hepatocellular carcinoma refractory to transarterial chemoembolization: a propensity-matched study

To investigate the efficacy and safety of tyrosine-kinase inhibitor (TKI) combined with iodine-125 seed brachytherapy (TKI-I) versus TKI alone for patients with hepatocellular carcinoma (HCC) refractory to tra...

Yongjian Guo, **gqiang Wu, Licong Liang, Kangshun Zhu, **gwen Zhou… in Cancer Imaging (2023)

Article

Inhibition of TRPV4 remodels single cell polarity and suppresses the metastasis of hepatocellular carcinoma

Hepatocellular carcinoma (HCC) is a malignant tumor, frequently causing both intrahepatic and extrahepatic metastases. The overall prognosis of patients with metastatic HCC is poor. Recently, single-cell (sc) ...

Jian Liu, Yongjian Guo, Ruitian Zhang, Ye Xu, Chengju Luo, Rui Wang… in Cell Death & Disease (2023)

Article

Inhibition of CEMIP potentiates the effect of sorafenib on metastatic hepatocellular carcinoma by reducing the stiffness of lung metastases

Hepatocellular carcinoma (HCC) with lung metastasis is associated with poor prognosis and poor therapeutic outcomes. Studies have demonstrated that stiffened stroma can promote metastasis in various tumors. Ho...

Mingyu Liu, Lulu **e, Yuying Zhang, Jianning Chen, **ang Zhang… in Cell Death & Disease (2023)

Article

LZ-101, a novel derivative of danofloxacin, induces mitochondrial apoptosis by stabilizing FOXO3a via blocking autophagy flux in NSCLC cells

Non-small-cell lung carcinoma (NSCLC) continues to be a vital disease worldwide for its high incidence and consequent mortality rate. In this study, we investigated the anti-cancer effect of LZ-101, a new deri...

Yongjian Guo, Yue Zhao, Yuxin Zhou, **aoqing Tang, Zhiyu Li… in Cell Death & Disease (2019)

Article

A crowdsourcing approach for reusing and meta-analyzing gene expression data

Naisha Shah, Yongjian Guo, Katherine V Wendelsdorf, Yong Lu… in Nature Biotechnology (2016)

Article

Correction: Corrigendum: An interactive web-based application for Comprehensive Analysis of RNAi-screen Data

Nature Communications 7: Article number: 10578 (2016); Published 23 February 2016; Updated 21 March 2016 The original version of this article contained an error in the spelling of the author Eugen Buehler, whi...

Bhaskar Dutta, Alaleh Azhir, Louis-Henri Merino, Yongjian Guo… in Nature Communications (2016)

Article

An interactive web-based application for Comprehensive Analysis of RNAi-screen Data

RNAi screens are widely used in functional genomics. Although the screen data can be susceptible to a number of experimental biases, many of these can be corrected by computational analysis. For this purpose, ...

Bhaskar Dutta, Alaleh Azhir, Louis-Henri Merino, Yongjian Guo… in Nature Communications (2016)

Article

DAVID Knowledgebase: a gene-centered database integrating heterogeneous gene annotation resources to facilitate high-throughput gene functional analysis

Due to the complex and distributed nature of biological research, our current biological knowledge is spread over many redundant annotation databases maintained by many independent groups. Analysts usually nee...

Brad T Sherman, Da Wei Huang, Qina Tan, Yongjian Guo, Stephan Bour… in BMC Bioinformatics (2007)

Article

The distribution of SNPs in human gene regulatory regions

As a result of high-throughput genoty** methods, millions of human genetic variants have been reported in recent years. To efficiently identify those with significant biological functions, a practical strate...

Yongjian Guo, D Curtis Jamison in BMC Genomics (2005)