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Article
Association of ErbB2 Ser1113 phosphorylation with epidermal growth factor receptor co-expression and poor prognosis in human breast cancer
The carboxyterminal domain of the epidermal growth factor receptor (EGFR) – a putative binding site for the ubiquitin ligase Cbl – is the site of serine phosphorylation events which are essential for ligand-de...
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Article
Factors influencing the cellular accumulation of SN-38 and camptothecin
Purpose: The influence of biophysical factors (drug metabolism, transport proteins, and chemical stability) on the cellular accumulation of camptothecin (CPT) and SN-38 was examined. Methods: Drug transporter RNA...
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Article
Phenoty** of N-acetyltransferase type 2 by caffeine from uncontrolled dietary exposure
The standard approach for phenoty** of the human arylamine N-acetyltransferase 2 (NAT2) uses urinary caffeine metabolite ratios after a caffeine test dose taken in after methylxanthine abstinence. We tested whe...
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Chapter and Conference Paper
Three-Dimensional Modelling of Fracture in Polycrystals
A great deal of research has been carried out on modelling the fracture of polycrystalline materials. However, this has been largely restricted to 2-D models and special cases of 3-D models, e.g. Smith et al. [1]...
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Chapter and Conference Paper
The Role of Sub-Boundaries in the Brittle Fracture of Polycrystalline Materials
Grain boundaries are resistant to the propagation of cleavage cracks in polycrystalline materials. Indeed, the importance of grain boundary orientation on the propagation of cracks, and in particular brittle c...
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Article
Open AccessCardiovascular magnetic resonance imaging in early anthracycline cardiotoxicity
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Article
Open AccessThe reproducibility of cardiac T2* measurement in thalassaemia major patients using bright and black blood sequences
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Article
Open AccessA phantom study of temperature-dependent MRI T2* measurement
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Article
Open AccessThe optimisation of cardiac iron overload assessment by systolic imaging
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Article
Open AccessTroponin release following endurance exercise: is inflammation the cause? a cardiovascular magnetic resonance study
The aetiology and clinical significance of troponin release following endurance exercise is unclear but may be due to transient myocardial inflammation. Cardiovascular magnetic resonance (CMR) affords us the o...
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Chapter and Conference Paper
Situating Quests: Design Patterns for Quest and Level Design in Role-Playing Games
The design of role-playing games (RPGs) is very complex, involving an intricate interweaving of narrative, quest design, and level design. As an important means for conveying the game’s story, quests dictate t...
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Article
Uptake and Transport of Novel Amphiphilic Polyelectrolyte-Insulin Nanocomplexes by Caco-2 Cells—Towards Oral Insulin
The influence of polymer architecture on cellular uptake and transport across Caco-2 cells of novel amphiphilic polyelectrolyte-insulin nanocomplexes was investigated.
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Article
Open AccessCardiac effects of anabolic steroid use amongst recreational body builders - a CMR study
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Article
Open AccessEstimation of outbreak severity and transmissibility: Influenza A(H1N1)pdm09 in households
When an outbreak of a novel pathogen occurs, some of the most pressing questions from a public-health point of view relate to its transmissibility, and the probabilities of different clinical outcomes followin...
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Article
Open AccessThe breast cancer, early disease: toxicity from therapy with epirubicin regimens - cardiac assessment and risk evaluation (BETTER-CARE) study: CMR with early gadolinium relative enhancement, but not high-sensitivity troponin T, predicts the risk of chronic anthracycline cardiotoxicity
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Article
Open AccessCMR shows that anthracycline cardiotoxicity is common in women treated for early breast cancer and associated with undiagnosed hypertension; but cannot be reliably detected using late-gadolinium enhancement imaging
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Article
Open AccessEffects of anabolic steroid use on myocardial perfusion in body-builders: a quantitative cardiovascular magnetic resonance Study
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Article
Impact of Intraoperative Distractions on Patient Safety: A Prospective Descriptive Study Using Validated Instruments
There is emerging evidence indicating that distractions in the operating room (OR) are prevalent. Studies have shown a negative impact of distractions, but they have been conducted mostly with residents in sim...
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Article
Ventricular structure, function, and focal fibrosis in anabolic steroid users: a CMR study
Anabolic steroid (AS) misuse is widespread amongst recreational bodybuilders; however, their effects on the cardiovascular system are uncertain. Our aim was to document the impact of AS use on cardiac structur...
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Article
Open AccessBiopsy-based calibration of T2* magnetic resonance for estimation of liver iron concentration and comparison with R2 Ferriscan
There is a need to standardise non-invasive measurements of liver iron concentrations (LIC) so clear inferences can be drawn about body iron levels that are associated with hepatic and extra-hepatic complicati...
