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Article
Open AccessFibroblast growth factor signalling influences homologous recombination-mediated DNA damage repair to promote drug resistance in ovarian cancer
Ovarian cancer patients frequently develop chemotherapy resistance, limiting treatment options. We have previously shown that individuality in fibroblast growth factor 1 (FGF1) expression influences survival and ...
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Article
Open AccessDiabetes status modifies the long-term effect of lipoprotein-associated phospholipase A2 on major coronary events
Lipoprotein-associated phospholipase A2 (Lp-PLA2) activity has an independent prognostic association with major coronary events (MCE). However, no study has investigated whether type 2 diabetes status modifies...
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Article
Open AccessHow to Cost the Implementation of Major System Change for Economic Evaluations: Case Study Using Reconfigurations of Specialist Cancer Surgery in Part of London, England
Studies have been published regarding the impact of major system change (MSC) on care quality and outcomes, but few evaluate implementation costs or include them in cost-effectiveness analysis (CEA). This is d...
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Paediatric Hand and Wrist
Paediatric hand disorders are common. These can be classified into congenital or acquired and treatments vary from simple reassurance in cases such as clinodactyly to a major reconstruction in cases such as ab...
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Article
Open AccessPublisher Correction: Combining Biomarkers with EMR Data to Identify Patients in Different Phases of Sepsis
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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Article
Open AccessCombining Biomarkers with EMR Data to Identify Patients in Different Phases of Sepsis
Sepsis is a leading cause of death and is the most expensive condition to treat in U.S. hospitals. Despite targeted efforts to automate earlier detection of sepsis, current techniques rely exclusively on using...
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Article
Open AccessABCB1 (MDR1) induction defines a common resistance mechanism in paclitaxel- and olaparib-resistant ovarian cancer cells
Clinical response to chemotherapy for ovarian cancer is frequently compromised by the development of drug-resistant disease. The underlying molecular mechanisms and implications for prescription of routinely p...
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Evaluating content generators
Evaluating your content generator is a very important task, but difficult to do well. Creating a game content generator in general is much easier than creating a good game content generator—but what is a “good...
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Chapter
Mixed-initiative content creation
Algorithms can generate game content, but so can humans. And while PCG algorithms can generate some kinds of game content remarkably well and extremely quickly, some other types (and aspects) of game content a...
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Article
Open AccessRecurrent Coding Sequence Variation Explains Only A Small Fraction of the Genetic Architecture of Colorectal Cancer
Whilst common genetic variation in many non-coding genomic regulatory regions are known to impart risk of colorectal cancer (CRC), much of the heritability of CRC remains unexplained. To examine the role of re...
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Article
Multi-scale characterization and modelling of damage evolution in nuclear Gilsocarbon graphite
In the present work, the microstructure and mechanical properties of Gilsocarbon graphite have been characterized over a range of length-scales. Optical imaging, combined with 3D X-ray computed tomography and ...
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Article
Open AccessBiopsy-based calibration of T2* magnetic resonance for estimation of liver iron concentration and comparison with R2 Ferriscan
There is a need to standardise non-invasive measurements of liver iron concentrations (LIC) so clear inferences can be drawn about body iron levels that are associated with hepatic and extra-hepatic complicati...
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Article
Ventricular structure, function, and focal fibrosis in anabolic steroid users: a CMR study
Anabolic steroid (AS) misuse is widespread amongst recreational bodybuilders; however, their effects on the cardiovascular system are uncertain. Our aim was to document the impact of AS use on cardiac structur...
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Article
Impact of Intraoperative Distractions on Patient Safety: A Prospective Descriptive Study Using Validated Instruments
There is emerging evidence indicating that distractions in the operating room (OR) are prevalent. Studies have shown a negative impact of distractions, but they have been conducted mostly with residents in sim...
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Article
Open AccessThe breast cancer, early disease: toxicity from therapy with epirubicin regimens - cardiac assessment and risk evaluation (BETTER-CARE) study: CMR with early gadolinium relative enhancement, but not high-sensitivity troponin T, predicts the risk of chronic anthracycline cardiotoxicity
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Article
Open AccessCMR shows that anthracycline cardiotoxicity is common in women treated for early breast cancer and associated with undiagnosed hypertension; but cannot be reliably detected using late-gadolinium enhancement imaging
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Open AccessEffects of anabolic steroid use on myocardial perfusion in body-builders: a quantitative cardiovascular magnetic resonance Study
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Article
Open AccessEstimation of outbreak severity and transmissibility: Influenza A(H1N1)pdm09 in households
When an outbreak of a novel pathogen occurs, some of the most pressing questions from a public-health point of view relate to its transmissibility, and the probabilities of different clinical outcomes followin...
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Open AccessCardiac effects of anabolic steroid use amongst recreational body builders - a CMR study
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Article
Uptake and Transport of Novel Amphiphilic Polyelectrolyte-Insulin Nanocomplexes by Caco-2 Cells—Towards Oral Insulin
The influence of polymer architecture on cellular uptake and transport across Caco-2 cells of novel amphiphilic polyelectrolyte-insulin nanocomplexes was investigated.
