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Article
Open AccessSystematic Analysis and Biomarker Study for Alzheimer’s Disease
Revealing the relationship between dysfunctional genes in blood and brain tissues from patients with Alzheimer’s Disease (AD) will help us to understand the pathology of this disease. In this study, we conduct...
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Article
Facile, productive, and cost-effective synthesis of a novel tetrazine-based iron oxide nanoparticle for targeted image contrast agents and nanomedicines
We have developed an operationally simple, time, and cost-effective protocol to produce a novel tetrazine-based iron oxide nanoparticle using commercially available and inexpensive materials. Our protocol proc...
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Article
Open AccessCorrection to: Clinical recommendations for cardiovascular magnetic resonance map** of T1, T2, T2* and extracellular volume: A consensus statement by the Society for Cardiovascular Magnetic Resonance (SCMR) endorsed by the European Association for Cardiovascular Imaging (EACVI)
In the original publication of this article [1] the “Competing interests” section was incorrect.
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Chapter and Conference Paper
The Deep Poincaré Map: A Novel Approach for Left Ventricle Segmentation
Precise segmentation of the left ventricle (LV) within cardiac MRI images is a prerequisite for the quantitative measurement of heart function. However, this task is challenging due to the limited availability...
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Article
Open AccessClinical recommendations for cardiovascular magnetic resonance map** of T1, T2, T2* and extracellular volume: A consensus statement by the Society for Cardiovascular Magnetic Resonance (SCMR) endorsed by the European Association for Cardiovascular Imaging (EACVI)
Parametric map** techniques provide a non-invasive tool for quantifying tissue alterations in myocardial disease in those eligible for cardiovascular magnetic resonance (CMR). Parametric map** with CMR now...
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Article
Open AccessImproved Liver R2* Map** by Averaging Decay Curves
Liver R2* map** is often degraded by the low signal-to-noise ratio (SNR) especially in the presence of severe iron. This study aims to improve liver R2* map** at low SNRs by averaging decay curves before t...
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Article
Open AccessPost-mortem study of the association between cardiac iron and fibrosis in transfusion dependent anaemia
Heart failure related to cardiac siderosis remains a major cause of death in transfusion dependent anaemias. Replacement fibrosis has been reported as causative of heart failure in siderotic cardiomyopathy in ...
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Article
Open AccessComparison of 3 T and 1.5 T for T2* magnetic resonance of tissue iron
T2* magnetic resonance of tissue iron concentration has improved the outcome of transfusion dependant anaemia patients. Clinical evaluation is performed at 1.5 T but scanners operating at 3 T are increasing in...
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Article
Open AccessValidation of T2* in-line analysis for tissue iron quantification at 1.5 T
There is a need for improved worldwide access to tissue iron quantification using T2* cardiovascular magnetic resonance (CMR). One route to facilitate this would be simple in-line T2* analysis widely available...
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Article
Open AccessT1 at 1.5T and 3T compared with conventional T2* at 1.5T for cardiac siderosis
Myocardial black blood (BB) T2* relaxometry at 1.5T provides robust, reproducible and calibrated non-invasive assessment of cardiac iron burden. In vitro data has shown that like T2*, novel native Modified Loo...
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Article
Open AccessIntegrated genomic approaches identify major pathways and upstream regulators in late onset Alzheimer’s disease
Previous studies have evaluated gene expression in Alzheimer’s disease (AD) brains to identify mechanistic processes, but have been limited by the size of the datasets studied. Here we have implemented a novel...
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Article
Open AccessCalibration of myocardial T2 and T1 against iron concentration
The assessment of myocardial iron using T2* cardiovascular magnetic resonance (CMR) has been validated and calibrated, and is in clinical use. However, there is very limited data assessing the relaxation param...
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Article
Open AccessBiopsy-based calibration of T2* magnetic resonance for estimation of liver iron concentration and comparison with R2 Ferriscan
There is a need to standardise non-invasive measurements of liver iron concentrations (LIC) so clear inferences can be drawn about body iron levels that are associated with hepatic and extra-hepatic complicati...
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Article
Open AccessValidation of Siemens T2* inline WIP package for quantification of cardiac and hepatic iron loading at 1.5T and 3T
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Article
Open AccessMyocardial iron assessment by T2* cardiovascular magnetic resonance at 3 Tesla
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Article
Open AccessComparison of white blood and black blood T2* cardiovascular magnetic resonance at 3 Tesla
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Article
Open AccessMyocardial iron assessment by T1 cardiovascular magnetic resonance at 1.5 Tesla
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Article
Open AccessMyocardial iron assessment by T1 cardiovascular magnetic resonance at 3 Tesla
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Article
Open AccessQuantitative assessment of myocardial extracellular volume fraction in non-ischemic dilated cardiomyopathy and its relation to systolic dysfunction
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Article
Open AccessPotential of pre-contrast T1 map** as a marker of interstitial fibrosis in severe aortic stenosis
