-
Article
Open AccessHigh-dimensional single-cell analysis of human natural killer cell heterogeneity
Natural killer (NK) cells are innate lymphoid cells (ILCs) contributing to immune responses to microbes and tumors. Historically, their classification hinged on a limited array of surface protein markers. Here...
-
Article
Open AccessQuadruple gene-engineered natural killer cells enable multi-antigen targeting for durable antitumor activity against multiple myeloma
Allogeneic natural killer (NK) cell adoptive transfer is a promising treatment for several cancers but is less effective for the treatment of multiple myeloma. In this study, we report on quadruple gene-engine...
-
Article
Promoting T and NK cell attack: preserving tumor MICA/B by vaccines
-
Chapter
The Past, Present, and Future of NK Cells in Hematopoietic Cell Transplantation and Adoptive Transfer
(HCT) has been used as a part of cancer therapy for over half a decade. Beyond the necessity for donor-derived cells to reconstitute hematopoiesis after radiation and chemotherapy, immunologic reconstitutio...
-
Chapter
Diversification and Functional Specialization of Human NK Cell Subsets
Natural killer (NK) cells are lymphocytes that participate in different facets of immunity. They can act as innate sentinels through recognition and eradication of infected or transformed target cells, so-call...
-
Protocol
In Vitro Development of Human Killer–Immunoglobulin Receptor-Positive NK Cells
The in vitro culture system outlined in this chapter allows for the delineation of events that occur during the development of CD34+ hematopoietic precursor cells into mature KIR+ human NK cells. This system can ...
