17 Result(s)
within
Michael R. Verneris
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Article
Open AccessAntiviral cellular therapy for enhancing T-cell reconstitution before or after hematopoietic stem cell transplantation (ACES): a two-arm, open label phase II interventional trial of pediatric patients with risk factor assessment
Viral infections remain a major risk in immunocompromised pediatric patients, and virus-specific T cell (VST) therapy has been successful for treatment of refractory viral infections in prior studies. We perfo...
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Article
Open AccessTargeting osteosarcoma with canine B7-H3 CAR T cells and impact of CXCR2 Co-expression on functional activity
The use of large animal spontaneous models of solid cancers, such as dogs with osteosarcoma (OS), can help develop new cancer immunotherapy approaches, including chimeric antigen receptor (CAR) T cells. The go...
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Article
Time to transplantation and pediatric acute myeloid leukemia outcomes
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Article
Open AccessProlactin Acts on Myeloid Progenitors to Modulate SMAD7 Expression and Enhance Hematopoietic Stem Cell Differentiation into the NK Cell Lineage
Numerous cell types modulate hematopoiesis through soluble and membrane bound molecules. Whether develo** hematopoietic progenitors of a particular lineage modulate the differentiation of other hematopoietic...
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Article
Open AccessSafety and feasibility of outpatient autologous stem cell transplantation in pediatric patients with primary central nervous system tumors
High-dose chemotherapy with autologous hematopoietic stem cell transplantation (autoHSCT) is a well-established treatment for pediatric central nervous system (CNS) tumors. Given the risks of toxicity and infe...
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Article
The effect of NIMA matching in adult unrelated mismatched hematopoietic stem cell transplantation – a joint study of the Acute Leukemia Working Party of the EBMT and the CIBMTR
Hematological malignancies can be cured by unrelated donor allogeneic HSCT and outcomes are optimized by high-resolution HLA matching at HLA-A, -B, -C, -DRB1 and -DQB1 (10/10 match). If a 10/10 match is unavai...
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Article
Genetic mechanisms of target antigen loss in CAR19 therapy of acute lymphoblastic leukemia
We identified genetic mutations in CD19 and loss of heterozygosity at the time of CD19– relapse to chimeric antigen receptor (CAR) therapy. The mutations are present in the vast majority of resistant tumor cells ...
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Article
Donor body mass index does not predict graft versus host disease following hematopoietic cell transplantation
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Article
No association between donor telomere length and outcomes after allogeneic unrelated hematopoietic cell transplant in patients with acute leukemia
Recent studies suggest improved survival in patients with severe aplastic anemia receiving hematopoietic cell transplant (HCT) from unrelated donors with longer telomeres. Here, we tested whether this effect i...
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Chapter
The Past, Present, and Future of NK Cells in Hematopoietic Cell Transplantation and Adoptive Transfer
(HCT) has been used as a part of cancer therapy for over half a decade. Beyond the necessity for donor-derived cells to reconstitute hematopoiesis after radiation and chemotherapy, immunologic reconstitutio...
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Chapter
Cord Blood Transplantation for Pediatric Hematologic Malignancies: Indications, Mechanisms, and Outcomes
Allogeneic stem cell transplantation is a life-saving modality for many hematologic malignancies. Due to the permissiveness of human leukocyte antigen (HLA) mismatches, umbilical cord blood (UCB) has increased...
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Article
Open AccessTransient regulatory T-cell (Treg) depletion with IL-2 diphtheria toxin fusion protein enhances clearance of acute myeloid leukemia by haploidentical natural killer (NK) cells
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Article
Novel Approaches to Prevent Leukemia Relapse Following Allogeneic Hematopoietic Cell Transplantation
Allogeneic hematopoietic cell transplantation is curative for patients with high-risk leukemia, but disease recurrence remains a major cause of treatment failure. New tools are now available to potentially ide...
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Protocol
Acquisition, Preparation, and Functional Assessment of Human NK Cells for Adoptive Immunotherapy
Human natural killer (NK) cells, a subset of peripheral blood lymphocytes that lack a T- or B-cell receptor, play a crucial role in the innate immune response to viruses and malignant cells. NK cells different...
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Article
Recent Developments in Cell-based Immune Therapy for Neuroblastoma
Neuroblastoma (NB) is a common and aggressive tumor of early childhood. To date, treatment with chemotherapy, surgery, and radiation therapy has resulted in suboptimal outcomes in those with advanced disease. ...
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Article
Studies of ex Vivo Activated and Expanded CD8+ NK-T Cells in Humans and Mice
Adoptive cellular therapy holds promise for improving the outcome of hematopoietic cell transplantation (HCT). At present, donor lymphocyte infusion post-HCT is efficacious for only a limited number of disease...
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Article
Resistance of ex vivo expanded CD3+CD56+ T cells to Fas-mediated apoptosis
A variety of malignancies express Fas ligand (FasL), which can induce apoptosis in effector lymphocytes and may limit the success of cellular immunotherapy. Our laboratory has been investigating a population ...
