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Article
Open AccessPan-cancer profiling of tumor-infiltrating natural killer cells through transcriptional reference map**
The functional diversity of natural killer (NK) cell repertoires stems from differentiation, homeostatic, receptor–ligand interactions and adaptive-like responses to viral infections. In the present study, we ...
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Article
Open AccessQuadruple gene-engineered natural killer cells enable multi-antigen targeting for durable antitumor activity against multiple myeloma
Allogeneic natural killer (NK) cell adoptive transfer is a promising treatment for several cancers but is less effective for the treatment of multiple myeloma. In this study, we report on quadruple gene-engine...
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Article
Open AccessRemodeling of secretory lysosomes during education tunes functional potential in NK cells
Inhibitory signaling during natural killer (NK) cell education translates into increased responsiveness to activation; however, the intracellular mechanism for functional tuning by inhibitory receptors remains...
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Article
Open AccessImmune selection during tumor checkpoint inhibition therapy paves way for NK-cell “missing self” recognition
The ability of NK cells to specifically recognize cells lacking expression of self-MHC class I molecules was discovered over 30 years ago. It provided the foundation for the “missing self” hypothesis. Research...
