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Article
Open AccessFunctional and mutational analysis after radiation and cetuximab treatment on prostate carcinoma cell line DU145
Epidermal Growth Factor Receptor is often overexpressed in advanced prostate carcinoma. In-vitro-studies in prostate carcinoma cell line DU145 have demonstrated increased sensibility to radiation after cetuxim...
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Article
Open AccessUreteroenteric strictures: a single center experience comparing Bricker versus Wallace ureteroileal anastomosis in patients after urinary diversion for bladder cancer
To evaluate the outcome and complication rate in a single institution experience using the two most commonly used techniques of ureteroenteric anastomosis, the Bricker and Wallace anastomosis.
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Article
Frühinstillation beim nicht muskelinvasiven Harnblasenkarzinom
Beim nicht muskelinvasiven Urothelkarzinom wird die Resektion und eine simultane Rezidivprophylaxe durch unmittelbar anschließende intravesikale Chemotherapie empfohlen. Dies setzt voraus, dass der Operateur n...
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Article
Hospital volume in ureterorenoscopic stone treatment: 99 operations per year could increase the chance of a better outcome—results of the German prospective multicentre BUSTER project
Despite the high utilisation of ureterorenoscopy (URS) in interventional stone treatment, there is little evidence of any link between annual hospital volume and outcome.
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Article
RANKL/RANK/OPG cytokine receptor system: mRNA expression pattern in BPH, primary and metastatic prostate cancer disease
The cytokine system RANKL (receptor activator of NF-κB ligand), its receptor RANK and the antagonist OPG (osteoprotegerin) play a critical role in bone turnover. Our investigation was conducted to describe the ge...
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Article
Nephron sparing surgery for renal cell carcinoma up to 7 cm in the context of guideline development: a contribution of healthcare research
If technically feasible, organ-preservation is indicated for T1 renal cell carcinoma (RCC), since partial nephrectomy (PN) is equivalent to radical nephrectomy with regard to tumor-specific survival and probab...
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Article
Chemokine receptor CCR6 expression level and aggressiveness of prostate cancer
CCR6 is expressed in various tumors and has been implicated in the process of tumor progression and metastasis. Its chemokine ligand, CCL20, is present in different tissues including lymph nodes, but also the ...
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Article
Expression levels of the mitochondrial IAP antagonists Smac/DIABLO and Omi/HtrA2 in clear-cell renal cell carcinomas and their prognostic value
Numerous molecular parameters are thought to be implicated in renal cell carcinoma (RCC) tumor biology and may therefore reflect the malignant potential of individual tumors. Their investigation may thus help ...
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Article
Expression of the polycomb group protein EZH2 and its relation to outcome in patients with urothelial carcinoma of the bladder
The polycomb group protein Enhancer of Zeste Homolg 2 (EZH2), a repressor of gene transcription, has been linked to the progression of various malignancies. This study was done to examine a potential correlati...
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Article
A gene expression profile of tumor suppressor genes commonly methylated in bladder cancer
The functional relationship between promoter hypermethylation and gene inactivation has been demonstrated for few genes only. We examined the promoter methylation status of two important tumor suppressor genes...
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Article
Epigenetic silencing of the putative tumor suppressor gene testisin in testicular germ cell tumors
Testisin, a serine protease abundantly expressed only in normal testes, is thought to be a tumor suppressor gene silenced by aberrant methylation in testicular germ cell tumors (TGCT). This study aimed at iden...
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Article
RDP1258, a New Rationally Designed Immunosuppressive Peptide, Prolongs Allograft Survival in Rats: Analysis of Its Mechanism of Action
Peptides derived from the HLA dass I heavy chain (a.a. 75–84) have been shown to modulate irnmune responses in vitro and in vivo in a non-allele-restricted fashion. In vivo studies in rodents have demonstrated...
