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Intravesikale Chemotherapie

Frühinstillation beim nicht muskelinvasiven Harnblasenkarzinom

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An Erratum to this article was published on 31 August 2019

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Beim nicht muskelinvasiven Urothelkarzinom wird die Resektion und eine simultane Rezidivprophylaxe durch unmittelbar anschließende intravesikale Chemotherapie empfohlen. Dies setzt voraus, dass der Operateur noch im Operationssaal die Entscheidung fällt, ob eine Frühinstillationstherapie indiziert ist.

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Abb. 1

Change history

  • 31 August 2019

    In Ausgabe 5/2019 S. 36 haben wir fälschlicherweise angegeben, in Deutschland seien zur Instillationstherapie die Chemotherapeutika Mitomycin C (MMC), Epirubicin und Doxorubicin sowie Gemcitabin und Thiotepa zugelassen. Richtig ist: In Deutschland sind Mitomycin C (MMC), Epirubicin und Doxorubicin zugelassen. Gemcitabin und Thiotepa hingegen sind zur intravesikalen Instillation nicht zugelassen. Bei der Anwendung von Gemcitabin oder Thiotepa zur intravesikalen Instillation handelt es sich somit um einen Off-Label-Use. Wir bitten um Beachtung.

Literatur

  1. Sylvester R J et al. Predicting recurrence and progression in individual patients with stage Ta T1 bladder cancer using EORTC risk tables. A combined analysis of 2596 patients from seven EORTC trials. Eur Urol. 2006; 49: 466–5

    Article  PubMed  Google Scholar 

  2. Stenzl A et al. Can we still afford bladder cancer? Curr Opin Urol. 2008; 18: 488–92

    Article  PubMed  Google Scholar 

  3. Reek, C et al. Versorgungsstandard bei neu diagnostiziertem Blasenkarzinom. Eine prospektive Erhebung in Norddeutschland. Der Urologe. 2013; 52: 986–90

    Article  CAS  PubMed  Google Scholar 

  4. Reznikoff CA et al. Genetic alterations and biological pathways in human bladder cancer pathogenesis. Urol Oncol. 2000; 5: 191–203

    Article  CAS  PubMed  Google Scholar 

  5. Soloway MS et al. (1980): Urothelial susceptibility to tumor cell implantation. Influence of cauterization. Cancer. 1980; 46: 1158–63

    Article  CAS  PubMed  Google Scholar 

  6. S3-Leitlinie Harnblasenkarzinom, 2016: Früherkennung, Diagnose, Therapie und Nachsorge des Harnblasenkarzinoms, Langversion. www.leitlinienprogramm-onkologie.de/Harnblasenkarzinom.92.0.html; abgerufen am 25.3.2019.

  7. Abern MR et al. Perioperative intravesical chemotherapy in non-muscle-invasive bladder cancer. A systematic review and meta-analysis. J Natl Compr Canc Netw. 2013; 11: 477–84

    Article  CAS  PubMed  Google Scholar 

  8. Sylvester RJ et al. Systematic Review and Individual Patient Data Meta-analysis of Randomized Trials Comparing a Single Immediate Instillation of Chemotherapy After Transurethral Resection with Transurethral Resection Alone in Patients with Stage pTa-pT1 Urothelial Carcinoma of the Bladder. Which Patients Benefit from the Instillation? Eur Urol. 2016; 69: 231–44

    Article  PubMed  Google Scholar 

  9. EAU Guideline NMIBC 2018: EAU Guidelines of non-muscle-invasive Bladder Cancer. Edn. presented at the EAU Annual Congress Copenhagen 2018, https://uroweb.org/guideline/non-muscle-invasive-bladder-cancer; abgerufen am 28.3.2019

  10. Retz M et al. Harnblasentumor in: Medikamentöse Tumortherapie in der Uroonkologie. Berlin, Heidelberg: Springer, 2. Auflage, 168–70

  11. Elmamoun MH et al. Destruction of the bladder by single dose Mitomycin C for low-stage transitional cell carcinoma (TCC)—avoidance, recognition, management and consent. BJU Int. 2014; 113: E34–8

    Article  CAS  PubMed  Google Scholar 

  12. Au JL et al. Methods to improve efficacy of intravesical mitomycin C. Results of a randomized phase III trial. J Natl Cancer Inst. 2001; 93: 597–604

    Article  CAS  PubMed  Google Scholar 

  13. Seo HK et al. Recommended oral sodium bicarbonate administration for urine alkalinization did not affect the concentration of mitomycin-C in non-muscle invasive bladder cancer patients. Oncotarget. 2017; 8: 96117–25

    PubMed  PubMed Central  Google Scholar 

  14. Palou-Redorta J et al. The use of immediate postoperative instillations of intravesical chemotherapy after TURBT of NMIBC among European countries. World J Urol. 2014; 32: 525–30

    Article  CAS  PubMed  Google Scholar 

  15. Lammers RJM et al. The role of a combined regimen with intravesical chemotherapy and hyperthermia in the management of non-muscle-invasive bladder cancer. A systematic review. Eur Urol. 2011; 60: 81–93

    Article  PubMed  Google Scholar 

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Authors and Affiliations

  1. Universitätsklinik für Urologie und Kinderurologie Magdeburg, Leipziger Straße 44, 39120, Magdeburg, Deutschland

    Tabea Koch

  2. http://www.springermedizin.de

    Frank Christoph, Martin Schostak & Simon Blaschke

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  1. Tabea Koch
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  2. Frank Christoph
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  4. Simon Blaschke
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Correspondence to Tabea Koch.

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Koch, T., Christoph, F., Schostak, M. et al. Frühinstillation beim nicht muskelinvasiven Harnblasenkarzinom. Uro-News 23, 35–39 (2019). https://doi.org/10.1007/s00092-019-2249-3

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