27 Result(s)
within
Francisco García-García
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Article
Open AccessThe role of microRNAs in understanding sex-based differences in Alzheimer’s disease
The incidence of Alzheimer's disease (AD)—the most frequent cause of dementia—is expected to increase as life expectancies rise across the globe. While sex-based differences in AD have previously been describe...
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Article
Open AccessNovel insight into the lipid network of plasma extracellular vesicles reveal sex-based differences in the lipidomic profile of alcohol use disorder patients
Alcohol use disorder (AUD) is one of the most common psychiatric disorders, with the consumption of alcohol considered a leading cause of preventable deaths worldwide. Lipids play a crucial functional role in ...
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Article
Open AccessRapid degeneration of iPSC-derived motor neurons lacking Gdap1 engages a mitochondrial-sustained innate immune response
Charcot-Marie-Tooth disease is a chronic hereditary motor and sensory polyneuropathy targeting Schwann cells and/or motor neurons. Its multifactorial and polygenic origin portrays a complex clinical phenotype ...
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Article
Open AccessLipidomic landscape of circulating extracellular vesicles isolated from adolescents exposed to ethanol intoxication: a sex difference study
Lipids represent essential components of extracellular vesicles (EVs), playing structural and regulatory functions during EV biogenesis, release, targeting, and cell uptake. Importantly, lipidic dysregulation ...
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Article
Ptpn1 deletion protects oval cells against lipoapoptosis by favoring lipid droplet formation and dynamics
Activation of oval cells (OCs) has been related to hepatocyte injury during chronic liver diseases including non-alcoholic fatty liver disease (NAFLD). However, OCs plasticity can be affected under pathologica...
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Article
Open AccessUnveiling sex-based differences in Parkinson's disease: a comprehensive meta-analysis of transcriptomic studies
In recent decades, increasing longevity (among other factors) has fostered a rise in Parkinson's disease incidence. Although not exhaustively studied in this devastating disease, the impact of sex represents a...
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Article
Open AccessNPC transplantation rescues sci-driven cAMP/EPAC2 alterations, leading to neuroprotection and microglial modulation
Neural progenitor cell (NPC) transplantation represents a promising treatment strategy for spinal cord injury (SCI); however, the underlying therapeutic mechanisms remain incompletely understood. We demonstrat...
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Article
Algorithms for processing the group K nearest-neighbor query on distributed frameworks
Given two datasets of points (called Query and Training), the Group (K) Nearest-Neighbor (GKNN) query retrieves (K) points of the Training with the smallest sum of distances to every point of the Query. This spat...
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Article
Open AccessCommon pathways and functional profiles reveal underlying patterns in Breast, Kidney and Lung cancers
Cancer is a major health problem which presents a high heterogeneity. In this work we explore omics data from Breast, Kidney and Lung cancers at different levels as signalling pathways, functions and miRNAs, a...
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Article
Open AccessHepatic steatosis and steatohepatitis: a functional meta-analysis of sex-based differences in transcriptomic studies
Previous studies have described sex-based differences in the epidemiological and clinical patterns of non-alcoholic fatty liver disease (NAFLD); however, we understand relatively little regarding the underlyin...
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Chapter and Conference Paper
Enhancing Sedona (formerly GeoSpark) with Efficient k Nearest Neighbor Join Processing
Sedona (formerly GeoSpark) is an in-memory cluster computing system for processing large-scale spatial data, which extends the core of Apache Spark to support spatial datatypes, partitioning techniques, indexes, ...
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Article
Open AccessExploring sunflower responses to Sclerotinia head rot at early stages of infection using RNA-seq analysis
Sclerotinia head rot (SHR), caused by the necrotrophic fungus Sclerotinia sclerotiorum, is one of the most devastating sunflower crop diseases. Despite its worldwide occurrence, the genetic determinants of plant ...
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Chapter and Conference Paper
MRSLICE: Efficient RkNN Query Processing in SpatialHadoop
Nowadays, with the continuously increasing volume of spatial data, it is difficult to execute spatial queries efficiently in spatial data-intensive applications, because of the limited computational capability...
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Article
Efficient large-scale distance-based join queries in spatialhadoop
Efficient processing of Distance-Based Join Queries (DBJQs) in spatial databases is of paramount importance in many application domains. The most representative and known DBJQs are the K Closest Pairs Query (KCPQ
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Chapter and Conference Paper
The Virtuality Continuum and Storytelling: Simulation, Interactivity, User Experience and Interaction Design in Virtual and Mixed Environments. A STEAM Based Approach
Virtual reality and digital environments are phenomena that have several theoretical and experimental approaches different domains research fields. The interactivity, simulation, or immersion in virtual enviro...
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Chapter and Conference Paper
Voronoi-Diagram Based Partitioning for Distance Join Query Processing in SpatialHadoop
SpatialHadoop is an extended MapReduce framework supporting global indexing techniques that partition spatial data across several machines and improve query processing performance compared to traditional Hadoo...
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Article
Integration of transcriptomic and metabolic data reveals hub transcription factors involved in drought stress response in sunflower (Helianthus annuus L.)
By integration of transcriptional and metabolic profiles we identified pathways and hubs transcription factors regulated during drought conditions in sunflower, useful for applications in molec...
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Chapter and Conference Paper
RkNN Query Processing in Distributed Spatial Infrastructures: A Performance Study
The Reverse k-Nearest Neighbor (RkNN) problem, i.e. finding all objects in a dataset that have a given query point among their corresponding k-nearest neighbors, has received increasing attention in the past year...
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Chapter and Conference Paper
A Comparison of Distributed Spatial Data Management Systems for Processing Distance Join Queries
Due to the ubiquitous use of spatial data applications and the large amounts of spatial data that these applications generate, the processing of large-scale distance joins in distributed systems is becoming in...
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Chapter and Conference Paper
SliceNBound: Solving Closest Pairs and Distance Join Queries in Apache Spark
The (K) Closest-Pair(s) Query, KCPQ, consists in finding the (K) closest pair(s) of objects between two spatial datasets. Recently, several systems that enhance Apache Spark with spatial-awareness have been p...
