18 Result(s)
within
Françoise Bressolle
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Article
A Novel Methodology to Estimate the Treatment Effect in Presence of Highly Variable Placebo Response
One of the main reasons for the inefficiency of multicenter randomized clinical trials (RCTs) in depression is the excessively high level of placebo response. The aim of this work was to propose a novel method...
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Article
A limited sampling strategy to estimate individual pharmacokinetic parameters of methotrexate in children with acute lymphoblastic leukemia
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Article
A limited sampling strategy to estimate individual pharmacokinetic parameters of methotrexate in children with acute lymphoblastic leukemia
The objectives of this study were to characterize the population pharmacokinetics of MTX in patients with acute lymphoblastic leukemia (ALL) with ages ranging from 2 to 16 years and to propose a limited sampli...
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Pharmacokinetics and pharmacodynamics of irinotecan and its metabolites from plasma and saliva data in patients with metastatic digestive cancer receiving Folfiri regimen
Purpose: Irinotecan is extensively metabolized into at least four compounds and previous pharmacokinetic–pharmacodynamic studies have given varying results. We hypothesized that saliva, a...
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Population pharmacokinetics of melphalan, infused over a 24-hour period, in patients with advanced malignancies
The objective of the present study was to characterize the population pharmacokinetics of melphalan infused over a 24-h period in patients with advanced malignancies.
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Article
Individual 5-FU dose adaptation in metastatic colorectal cancer: results of a phase II study using a bimonthly pharmacokinetically intensified LV5FU2 regimen
The aim of this phase II study was to determine the efficacy and tolerability of the bimonthly, pharmacokinetically intensified LV5FU2 regimen in the treatment of metastatic colorectal cancers.
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Article
Pharmacokinetic-Pharmacodynamic Modelling of Ketamine in Six Neurotraumatised Intensive Care Patients
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Blood and plasma pharmacokinetics of vinorelbine in elderly patients with advanced metastatic cancer
Purpose: As vinorelbine is 78% bound to platelets, it seems interesting to investigate the pharmacokinetic profile of this drug from blood and to compare it to that determined from plasma. Thus, in this study, t...
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Circadian rhythm of 5-fluorouracil population pharmacokinetics in patients with metastatic colorectal cancer
Purpose: The purpose of this work was to estimate the population pharmacokinetic parameters of 5-fluorouracil (5-FU) in patients with advanced colorectal cancer using circadian change kinetics. Methods: Eighty-f...
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Article
Predictive Performance of a Semiparametric Method to Estimate Population Pharmacokinetic Parameters Using NONMEM
Routine clinical pharmacokinetic (PK) data collected from patients receiving inulin were analyzed to estimate population PK parameters; 560 plasma concentration determinations for inulin were obt...
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Article
Time-dependent Pharmacokinetics of High Dose Thiopental Infusion in Intensive Care Patients
Purpose. In patients with severe head injuries receiving long-term infusion for reducing intracranial pressure, a decline in concentrations was apparent following attainment of an initial steady state. This coul...
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Article
Methyl-β-cyclodextrin in HL-60 parental and multidrug-resistant cancer cell lines: effect on the cytotoxic activity and intracellular accumulation of doxorubicin
The purpose of this work was to determine the role of methyl-β-cyclodextrin (MEBCD) in combination with doxorubicin (DOX) on the cellular proliferation of a sensitive parental and a multidrug-resistant human ...
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Article
Comparison of a Direct and Indirect Population Pharmacodynamic Model: Application to Recombinant Human Erythropoietin in Athletes
Basic physiologic indirect response models have been proposed to account for the pharmacodynamics of drugs that act by way of inhibition or stimulation of the production or loss of endogenous sub...
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Cisplatin-induced renal toxicity and toxicity-modulating strategies: a review
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Article
Multiple-Dose Pharmacokinetics of Pefloxacin in Patients with Hepatocellular Deficiency
Multiple-dose pharmacokinetics of pefloxacin were evaluated in 25 patients with hepatocellular insufficiency. The severity of liver disease was graded A, B or C according to the Child-Pugh classification. Phar...
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Article
Identification of Patients with Impaired Hepatic Drug Metabolism Using a Limited Sampling Procedure for Estimation of Phenazone (Antipyrine) Pharmacokinetic Parameters
Phenazone (antipyrine) 1g was given by short intravenous infusion to 62 study participants (10 healthy drug-free volunteers and 52 patients with chronic liver disease). A Bayesian approach was developed to det...
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Article
Doxorubicin and doxorubicinol plasma concentrations and excretion in parotid saliva
The pharmacokinetics of doxorubicin (DOX) and doxorubicinol (DOXol) was studied in six patients with various advanced neoplastic diseases who received 28–72 mg/m2 DOX (nine courses). Plasma and parotid saliva wer...
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Article
Doxorubicin and doxorubicinol: intra-and inter-individual variations of pharmacokinetic parameters
Doxorubicin was given by short i. v. infusion (dose range 25–72 mg/m2) to 18 patients who underwent three to seven successive courses of chemotherapy (total, 57 courses). Plasma levels of doxorubicin and its majo...
