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Article
Open AccessRole of Modeling and Simulation in Preclinical and Clinical Long-Acting Injectable Drug Development
Innovations in the field of long-acting injectable drug development are increasingly being reported. More advanced in vitro and in vivo characterization can improve our understanding of the injection space and ai...
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Article
Hydrothermal Uranium Mineralization in Umra, Udaipur District, Rajasthan, India: Inferences from Petrography, Mineral Chemistry and Sulfur Isotopic Studies
Uranium mineralization at Umra, Udaipur district, Rajasthan is hosted by carbon and siliceous phyllite (with minor calcareous components) of the Paleoproterozoic Aravalli Supergroup. The mineralized zone trend...
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Article
Open AccessClinical Pharmacokinetics, Safety, and Tolerability of a Novel, First-in-Class TRPV4 Ion Channel Inhibitor, GSK2798745, in Healthy and Heart Failure Subjects
Pulmonary capillary endothelial transient receptor potential vanilloid 4 (TRPV4) channel plays a critical role in mediating the development of cardiogenic pulmonary edema. GSK2798745 is a first-in-class, highl...
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Article
Open AccessApplication of the Stable Isotope Label Approach in Clinical Development—Supporting Dissolution Specifications for a Commercial Tablet Product with Tafenoquine, a Long Half-life Compound
Bioavailability/bioequivalence studies supporting clinical drug development or commercial supply of drug formulations are often time, cost, and resource intensive. The drug’s pharmacokinetic (PK) variability, ...
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Article
The American Conference on Pharmacometrics 2017 (ACoP8)
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Article
The Role of Drug Exposure in Clinical Development: To What Extent Is Pharmacokinetic Assessment Needed in a Drug Development Programme?
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Article
A Novel Methodology to Estimate the Treatment Effect in Presence of Highly Variable Placebo Response
One of the main reasons for the inefficiency of multicenter randomized clinical trials (RCTs) in depression is the excessively high level of placebo response. The aim of this work was to propose a novel method...
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Article
Dose–response modelling of umeclidinium and fluticasone furoate/umeclidinium in asthma
In two dose-ranging crossover studies, the long-acting muscarinic antagonist umeclidinium (UMEC) was assessed as monotherapy in patients with asthma not treated with inhaled corticosteroids (ICS) (NCT01641692 ...
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Article
Population Pharmacokinetics of Inhaled Umeclidinium and Vilanterol in Patients with Chronic Obstructive Pulmonary Disease
A fixed-dose combination of the bronchodilators umeclidinium and vilanterol is in development for the long-term, once-daily treatment of chronic obstructive pulmonary disease (COPD). We characterized the pharm...
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Article
Exposure–Response modeling of anti-depressant treatments: the confounding role of placebo effect
Emerging evidence indicates that the selection of patients and the selection of recruitment centers in placebo-controlled, randomized clinical trials (RCTs) in depression have a substantial impact on the proba...
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Article
Dynamic vs. Oblivious Routing in Network Design
Consider the robust network design problem of finding a minimum cost network with enough capacity to route all traffic demand matrices in a given polytope. We investigate the impact of different routing models...
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Chapter and Conference Paper
Dynamic vs. Oblivious Routing in Network Design
Consider the robust network design problem of finding a minimum cost network with enough capacity to route all traffic demand matrices in a given polytope. We investigate the impact of different routing models...
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Article
An Algorithmic Approach to the Identification of Rigid Domains in Proteins
Many proteins undergo conformational changes to perform their functions. A simple mechanism of conformational change in proteins is a rigid domain motion, in which two parts of a structure move rigidly with r...
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Article
The Graham-Knowlton Problem Revisited
In the late 60s Graham and Knowlton introduced the WIP (wire identification problem) that affected electricians: match the wires in the ceiling to those in the basement while making the fewest trips. We revisi...
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Chapter and Conference Paper
An Efficient Approximation Algorithm for Point Pattern Matching Under Noise
Point pattern matching problems are of fundamental importance in various areas including computer vision and structural bioinformatics. In this paper, we study one of the more general problems, known as LCP (l...
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Chapter and Conference Paper
A Combinatorial Shape Matching Algorithm for Rigid Protein Docking
The protein docking problem is to predict the structure of protein-protein complexes from the structures of individual proteins. It is believed that shape complementarity plays a dominant role in protein docki...
