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  1. Article

    Open Access

    Acan downregulation in parvalbumin GABAergic cells reduces spontaneous recovery of fear memories

    While persistence of fear memories is essential for survival, a failure to inhibit fear in response to harmless stimuli is a feature of anxiety disorders. Extinction training only temporarily suppresses fear m...

    Marisol Lavertu-Jolin, Bidisha Chattopadhyaya, Pegah Chehrazi… in Molecular Psychiatry (2023)

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  2. Article

    Spatial multi-omic map of human myocardial infarction

    Myocardial infarction is a leading cause of death worldwide1. Although advances have been made in acute treatment, an incomplete understanding of remodelling processes has limited the effectiveness of therapies t...

    Christoph Kuppe, Ricardo O. Ramirez Flores, Zhijian Li, Sikander Hayat… in Nature (2022)

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    Article

    Loss of ADAMTS19 causes progressive non-syndromic heart valve disease

    Valvular heart disease is observed in approximately 2% of the general population1. Although the initial observation is often localized (for example, to the aortic or mitral valve), disease manifestations are regu...

    Florian Wünnemann, Asaf Ta-Shma, Christoph Preuss, Severine Leclerc… in Nature Genetics (2020)

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    Article

    ROBO4 variants predispose individuals to bicuspid aortic valve and thoracic aortic aneurysm

    Bicuspid aortic valve (BAV) is a common congenital heart defect (population incidence, 1–2%)1–3 that frequently presents with ascending aortic aneurysm (AscAA)4. BAV/AscAA shows autosomal dominant inheritance wit...

    Russell A. Gould, Hamza Aziz, Courtney E. Woods… in Nature Genetics (2019)

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    Chapter

    Molecular Pathways and Animal Models of Hypoplastic Left Heart Syndrome

    Hypoplastic left heart syndrome (HLHS) is a rare and severe defect in which the structures of the left side of the heart are severely underdeveloped. Only a very small minority of HLHS cases can currently be e...

    Florian Wünnemann, Gregor U. Andelfinger in Congenital Heart Diseases: The Broken Heart (2016)

  6. No Access

    Article

    Mutations in SGOL1 cause a novel cohesinopathy affecting heart and gut rhythm

    Gregor Andelfinger and colleagues identify mutations in SGOL1 that cause a novel cohesinopathy characterized by chronic atrial and intestinal dysrhythmia, termed CAID syndrome. SGOL1 encodes a component of the co...

    Philippe Chetaille, Christoph Preuss, Silja Burkhard, Jean-Marc Côté… in Nature Genetics (2014)