5 Result(s)
within
Bidisha Chattopadhyaya
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Article
Open AccessAcan downregulation in parvalbumin GABAergic cells reduces spontaneous recovery of fear memories
While persistence of fear memories is essential for survival, a failure to inhibit fear in response to harmless stimuli is a feature of anxiety disorders. Extinction training only temporarily suppresses fear m...
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Article
Open AccessSensitive period for rescuing parvalbumin interneurons connectivity and social behavior deficits caused by TSC1 loss
The Mechanistic Target Of Rapamycin Complex 1 (mTORC1) pathway controls several aspects of neuronal development. Mutations in regulators of mTORC1, such as Tsc1 and Tsc2, lead to neurodevelopmental disorders a...
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Article
Open AccessDecrease of SYNGAP1 in GABAergic cells impairs inhibitory synapse connectivity, synaptic inhibition and cognitive function
Haploinsufficiency of the SYNGAP1 gene, which codes for a Ras GTPase-activating protein, impairs cognition both in humans and in mice. Decrease of Syngap1 in mice has been previously shown to cause cognitive defi...
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Article
Activity-dependent PSA expression regulates inhibitory maturation and onset of critical period plasticity
Functional maturation of GABAergic innervation in the develo** visual cortex is regulated by neural activity and sensory inputs and in turn influences the critical period of ocular dominance plasticity. Here...
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Article
Subcellular domain-restricted GABAergic innervation in primary visual cortex in the absence of sensory and thalamic inputs
Distinct classes of GABAergic synapses target restricted subcellular domains, thereby differentially regulating the input, integration and output of principal neurons, but the underlying mechanism for such syn...
