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Article
Open AccessAcan downregulation in parvalbumin GABAergic cells reduces spontaneous recovery of fear memories
While persistence of fear memories is essential for survival, a failure to inhibit fear in response to harmless stimuli is a feature of anxiety disorders. Extinction training only temporarily suppresses fear m...
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Article
Spatial multi-omic map of human myocardial infarction
Myocardial infarction is a leading cause of death worldwide1. Although advances have been made in acute treatment, an incomplete understanding of remodelling processes has limited the effectiveness of therapies t...
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Article
Loss of ADAMTS19 causes progressive non-syndromic heart valve disease
Valvular heart disease is observed in approximately 2% of the general population1. Although the initial observation is often localized (for example, to the aortic or mitral valve), disease manifestations are regu...
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Article
ROBO4 variants predispose individuals to bicuspid aortic valve and thoracic aortic aneurysm
Bicuspid aortic valve (BAV) is a common congenital heart defect (population incidence, 1–2%)1–3 that frequently presents with ascending aortic aneurysm (AscAA)4. BAV/AscAA shows autosomal dominant inheritance wit...
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Chapter
Molecular Pathways and Animal Models of Hypoplastic Left Heart Syndrome
Hypoplastic left heart syndrome (HLHS) is a rare and severe defect in which the structures of the left side of the heart are severely underdeveloped. Only a very small minority of HLHS cases can currently be e...
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Article
Mutations in SGOL1 cause a novel cohesinopathy affecting heart and gut rhythm
Gregor Andelfinger and colleagues identify mutations in SGOL1 that cause a novel cohesinopathy characterized by chronic atrial and intestinal dysrhythmia, termed CAID syndrome. SGOL1 encodes a component of the co...