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Article
Study on the Influence of Annealing and Ball Milling on the Magnetic Properties of HDDR Nd-Fe-B Magnetic Powder
The Nd-Fe-B anisotropic magnetic powders were subjected to tempering and ball milling processes. Analysis of the magnetic properties, structure, and physical phase revealed that the following: the integrated m...
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Article
Open AccessClinical outcomes and biomarker exploration of first-line PD-1 inhibitors plus chemotherapy in patients with low PD-L1-expressing of gastric or gastroesophageal junction adenocarcinoma
The beneficial effects of first-line programmed death-1 (PD-1) inhibitors plus chemotherapy in patients with low programmed death-ligand 1 (PD-L1)-expressing advanced gastric or gastroesophageal junction (G/GE...
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Article
Open AccessA time-resolved multi-omics atlas of transcriptional regulation in response to high-altitude hypoxia across whole-body tissues
High-altitude hypoxia acclimatization requires whole-body physiological regulation in highland immigrants, but the underlying genetic mechanism has not been clarified. Here we use sheep as an animal model for ...
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Article
Cr-catalyzed allylic C(sp3)–H addition to aldehydes enabled by photoinduced ligand-to-metal charge transfer
Photoinduced ligand-to-metal charge transfer (LMCT) has emerged as an effective strategy for synthesizing organic molecules in a sustainable manner. However, the majority of existing reports on selective C(sp3)–H...
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Article
Combined anti-PD-1, HDAC inhibitor and anti-VEGF for MSS/pMMR colorectal cancer: a randomized phase 2 trial
Epigenetic modifications of chromatin, including histone acetylation, and tumor angiogenesis play pivotal roles in creating an immunosuppressive tumor microenvironment. In the randomized phase 2 CAPability-01 ...
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Article
Intratumoral and peritumoral MRI radiomics nomogram for predicting parametrial invasion in patients with early-stage cervical adenocarcinoma and adenosquamous carcinoma
To develop a comprehensive nomogram based on MRI intra- and peritumoral radiomics signatures and independent risk factors for predicting parametrial invasion (PMI) in patients with early-stage cervical adenoca...
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Article
Open AccessCirculating secretoneurin level reflects angiographic coronary collateralization in stable angina patients with chronic total occlusion
To investigate the association between circulating secretoneurin (SN) and angiographic coronary collateralization in stable angina patients with chronic coronary total occlusion (CTO).
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Chapter and Conference Paper
Research on Development Law of Deep Coalbed Gas Reservoirs at Eastern Edge of the Ordos Basin
The characteristics of deep coalbed methane development are significantly different from those of shallow ones. The development of deep coalbed methane is obviously affected by free gas, and the gas is seen ea...
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Article
Heteroepitaxial growth of Au@Pd core–shell nanocrystals with intrinsic chiral surfaces for enantiomeric recognition
Noble metal surfaces with intrinsic chirality serve as an ideal candidate for investigating enantioselective chemistry due to their superior chemical durability and high catalytic activity. Recently, significa...
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Article
DZ2002 alleviates corneal angiogenesis and inflammation in rodent models of dry eye disease via regulating STAT3-PI3K-Akt-NF-κB pathway
Dry eye disease (DED) is a prevalent ocular disorder with a multifactorial etiology. The pre-angiogenic and pre-inflammatory milieu of the ocular surface plays a critical role in its pathogenesis. DZ2002 is a ...
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Article
Effects of magnetic field and hydrostatic pressure on the antiferromagnetic–ferromagnetic transition and magneto-functional properties in Hf1-xTaxFe2 alloys
In this study, the thermal expansion of Hf1-xTaxFe2 (x = 0.10, 0.13, 0.15) compounds by adjusting the Ta concentration was successfully regulated. The magnetocaloric properties, hydrostatic pressure affecting the...
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Article
Open AccessComprehensive analysis reveals potential therapeutic targets and an integrated risk stratification model for solitary fibrous tumors
Solitary fibrous tumors (SFTs) are rare mesenchymal tumors with unpredictable evolution and with a recurrence or metastasis rate of 10-40%. Current medical treatments for relapsed SFTs remain ineffective. Here...
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Article
Approximate quantum gates compilation for superconducting transmon qubits with self-navigation algorithm
Precise and fast qubit control is crucial when compiling quantum gates for successful implementation of quantum algorithms. However, the presence of environmental noise and the nonzero bandwidth of control pul...
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Article
Open AccessPrevalence and genomic analysis of t203-like G9 (G9-VI) rotaviruses circulating in children with gastroenteritis in Bei**g, China
Our previous surveillance revealed that t203-like G9 (tentatively designated subtype G9-VI) rotaviruses re-emerged in 2010 in Bei**g and rapidly prevailed over the G9-III subtype (the most common G9 subtype g...
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Article
Open AccessDynamic single-cell map** unveils Epstein‒Barr virus-imprinted T-cell exhaustion and on-treatment response
Epstein‒Barr virus (EBV)-associated gastric cancer (GC) manifests an intriguing immunotherapy response. However, the cellular basis for EBV-imprinted tumour immunity and on-treatment response remains undefined...
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Article
Open AccessRobotic-OCT guided inspection and microsurgery of monolithic storage devices
Data recovery from monolithic storage devices (MSDs) is in high demand for legal or business purposes. However, the conventional data recovery methods are destructive, complicated, and time-consuming. We devel...
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Article
Role of Cyclin D1b in Inducing Macrophages Toward a Tumor-associated Macrophage-like Phenotype in Murine Breast Cancer
Tumor-associated macrophages (TAMs) of the M2 phenotype are frequently associated with cancer progression. Invasive cancer cells undergoing epithelial-mesenchymal transition (EMT) have a selective advantage as...
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Article
Artificial cultivation and evaluation of two late fall oyster strains (Sarcomyxa edulis) from Jilin, China
Sarcomyxa edulis is a low-temperature mushroom of Northeastern Asia. Although this mushroom is highly popular in this region, it is not currently cultivated on a large scale. In this study, two Sarcomyxa edulis s...
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Article
An optimization of harmonic structure nickel-saving cryogenic steel via combinatorial high-throughput experiment
A combinatorial high-throughput experiment (HTE) was used to optimize composition and process of nickel-saving cryogenic steel. A gradient temperature heat treatment method with a high linear distribution of h...
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Article
Open AccessWhole-body adipose tissue multi-omic analyses in sheep reveal molecular mechanisms underlying local adaptation to extreme environments
The fat tail of sheep is an important organ that has evolved to adapt to extreme environments. However, the genetic mechanisms underlying the fat tail phenotype remain poorly understood. Here, we characterize ...
