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Article
Open AccessIntrauterine chilled saline instillation reduces endometrial impairment on MRI after ultrasound-guided percutaneous microwave ablation of uterine adenomyosis
To investigate whether intrauterine chilled saline can reduce endometrial impairment during US-guided percutaneous microwave ablation (PMWA) of adenomyosis.
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Article
Prediction of Ablation Rate for High-Intensity Focused Ultrasound Therapy of Adenomyosis in MR Images Based on Multi-model Fusion
This study aimed to develop a model based on radiomics and deep learning features to predict the ablation rate in patients with adenomyosis undergoing high-intensity focused ultrasound (HIFU) therapy. A total ...
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Article
Open AccessSource analysis and health risk assessment of polycyclic aromatic hydrocarbon (PAHs) in total suspended particulate matter (TSP) from Bengbu, China
The polycyclic aromatic hydrocarbon (PAH) concentrations in total suspended particulate matter (TSP) samples collected from October, 2021 to September, 2022 were analyzed to clarify the pollution characteristi...
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Article
Intratumoral and peritumoral MRI radiomics nomogram for predicting parametrial invasion in patients with early-stage cervical adenocarcinoma and adenosquamous carcinoma
To develop a comprehensive nomogram based on MRI intra- and peritumoral radiomics signatures and independent risk factors for predicting parametrial invasion (PMI) in patients with early-stage cervical adenoca...
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Article
Open AccessWear Performance of a Novel Silicon Nitride Ceramic for Biomedical Applications
Ceramic materials are sometimes used as bearing surfaces of joint implants due to their high wear resistance and biocompatibility. Silicon nitride (Si3N4) is one of the ceramics under investigation for such use, ...
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Article
Open AccessEnhanced Bacteriostatic Properties of Ti Alloys by Surface Nitriding
Surface nitriding has been widely used to improve the surface physicochemical properties of Ti alloys. However, the currently utilized surface nitriding methods, such as laser nitriding, typically require expe...
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Article
Open AccessEffect of post-extubation high-flow nasal cannula combined with respiratory training versus conventional oxygen therapy on postoperative pulmonary complications in patients after major abdominal surgery: protocol for a single-centre randomized controlled trial
Nearly 234 million patients undergo surgery each year, and 1.3 million among them develop complications. Patients undergoing major upper abdominal surgery (operation time > 2 h) have a really high incidence of...
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Article
Three-dimensional quantitative structural-activity relationship and molecular dynamics study of multivariate substituted 4-oxyquinazoline HDAC6 inhibitors
3D-QSAR models were established by collecting 46 multivariate-substituted 4-oxyquinazoline HDAC6 inhibitors. The relationship of molecular structure and inhibitory activity was studied by comparative molecular...
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Article
Target based structural optimization of substituted pyrazolopyrimidine analogues as inhibitor for IRAK4 by 3D-QSAR and molecular simulation
3D-QSAR models were established using 52 compounds of pyrazolopyrimidine analogues with multiple substituents. We studied the relationship between molecular structure and inhibitory activity using comparative ...
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Article
Open AccessThe role of three-dimensional MRI in the differentiation between angular pregnancy and interstitial pregnancy
In clinical practice it is an ongoing challenge to distinguish between angular pregnancy and interstitial pregnancy. With the three-dimensional (3D) magnetic resonance imaging (MRI) being increasingly used, it...
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Article
Open AccessEffectiveness of protection areas in safeguarding biodiversity and ecosystem services in Tibet Autonomous Region
The Tibet Autonomous Region of China constitutes a unique and fragile ecosystem that is increasingly influenced by development and global climate change. To protect biodiversity and ecosystem services in Tibet...
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Article
A selectivity study of polysubstituted pyridinylimidazoles as dual inhibitors of JNK3 and p38α MAPK based on 3D-QSAR, molecular docking, and molecular dynamics simulation
Within the mitogen-activated protein kinase (MAPK) 1 family, the two kinases of c-Jun N-terminal kinase 3 (JNK3) and p38α MAPK have emerged in the last decades as particularly attractive therapeutic targets du...
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Article
The value of microendoscopy in the diagnosis of cervical precancerous lesions and cervical microinvasive carcinoma
Cervical cancer is still one of the main causes of death in females. Conventional diagnostic tools such as colposcopy are still unsatisfactory, so accurate diagnostic tools for cervical diseases are needed. Th...
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Article
3D-QSAR, HQSAR, molecular docking, and new compound design study of 1,3,6-trisubstituted 1,4-diazepan-7-ones as human KLK7 inhibitors
The skin is an important barrier against environmental factors. Foregoing studies has shown that human KLK7 is a protease which promoted epidermal shedding, affected the epidermal barrier and increased the ris...
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Article
The effects of parafoveal word frequency and segmentation on saccade targeting during Chinese reading
Two eye-movement experiments are reported in which a boundary paradigm was used to manipulate the presence versus absence of boundaries for high-frequency and low-frequency target words in the parafovea. In Ex...
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Article
Biological floating bed and bio-contact oxidation processes for landscape water treatment: simultaneous removal of Microcystis aeruginosa, TOC, nitrogen and phosphorus
The aim of this study was to identify algicidal bacteria J25 against the Microcystis aeruginosa (90.14%), Chlorella (78.75%), Scenedesmus (not inhibited), and Oscillatoria (90.12%). Meanwhile, we evaluate the SOD...
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Article
Unglycosylation at Asn-633 made extracellular domain of E-cadherin folded incorrectly and arrested in endoplasmic reticulum, then sequentially degraded by ERAD
The human E-cadherin is a single transmembrane domain protein involved in Ca2+-dependent cell–cell adhesion. In a previous study, we demonstrated that all of four potential N-glycosylation sites in E-cadherin are...
