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Article
Open AccessInhalation exposure to cigarette smoke and inflammatory agents induces epigenetic changes in the lung
Smoking-related lung tumors are characterized by profound epigenetic changes including scrambled patterns of DNA methylation, deregulated histone acetylation, altered gene expression levels, distorted microRNA...
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Article
RNA-sequencing studies identify genes differentially regulated during inflammation-driven lung tumorigenesis and targeted by chemopreventive agents
Chronic pulmonary inflammation has been consistently shown to increase the risk of lung cancer. Therefore, assessing the molecular links between the two diseases and identification of chemopreventive agents th...
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Article
Chemoprevention of lung carcinogenesis in addicted smokers and ex-smokers
Lung cancer kills more than 3,000 people every day, and most of this toll is due to cigarette smoking. Although tobacco control is clearly the most desirable w...
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Article
Effect of chrysin, a flavonoid compound, on the mutagenic activity of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) and benzo(a)pyrene (B(a)P) in bacterial and human hepatoma (HepG2) cells
The aim of the present study was to investigate the antimutagenic effects of chrysin (CR), a flavonoid compound contained in many fruits, vegetables and honey. Earlier investigations with bacterial indicators ...
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Dietary Induction of Phase II Enzymes: A Promising Strategy for Protection Against DNA-Reactive Intermediates in Man?
Over the last decades, strong efforts have been made to identify chemoprotective agents in in vitro models with mammalian cells and in laboratory rodents and numerous molecular studies have been carried out to...
