83 Result(s)

Article

PARP1-DNA co-condensation: the driver of broken DNA repair

**ang Wei, Fangfang Zhou, Long Zhang in Signal Transduction and Targeted Therapy (2024)

Article

TRIM25 predominately associates with anti-viral stress granules

Stress granules (SGs) are induced by various environmental stressors, resulting in their compositional and functional heterogeneity. SGs play a crucial role in the antiviral process, owing to their potent tran...

Zehua Shang, Sitao Zhang, **rui Wang, Lili Zhou, **nyue Zhang… in Nature Communications (2024)

Article

Oxygen glucose deprivation-pretreated astrocyte-derived exosomes attenuates intracerebral hemorrhage (ICH)-induced BBB disruption through miR-27a-3p /ARHGAP25/Wnt/β-catenin axis

Blood brain barrier (BBB) breakdown is one of the key mechanisms of secondary brain injury following intracerebral hemorrhage (ICH). Astrocytes interact with endothelial and regulate BBB integrity via paracrin...

Ying Hou, Ye **e, **aoxuan Liu, Yushan Chen… in Fluids and Barriers of the CNS (2024)

Article

TRIM28-mediated nucleocapsid protein SUMOylation enhances SARS-CoV-2 virulence

Viruses, as opportunistic intracellular parasites, hijack the cellular machinery of host cells to support their survival and propagation. Numerous viral proteins are subjected to host-mediated post-translation...

Jiang Ren, Shuai Wang, Zhi Zong, Ting Pan, Sijia Liu, Wei Mao… in Nature Communications (2024)

Article

Functions of MAP3Ks in antiviral immunity

Immune signal transduction is crucial to the body’s defense against viral infection. Recognition of pathogen-associated molecular patterns by pattern recognition receptors (PRRs) activates the transcription of...

Jizhong Guan, Yao Fan, Shuai Wang, Fangfang Zhou in Immunologic Research (2023)

Article

Reliable knowledge graph fact prediction via reinforcement learning

Knowledge graph (KG) fact prediction aims to complete a KG by determining the truthfulness of predicted triples. Reinforcement learning (RL)-based approaches have been widely used for fact prediction. However,...

Fangfang Zhou, Jiapeng Mi, Beiwen Zhang… in Visual Computing for Industry, Biomedicine… (2023)

Article

DNAJB4 suppresses breast cancer progression and promotes tumor immunity by regulating the Hippo signaling pathway

Breast cancer is the most common cancer worldwide. Low DNAJB4 expression levels are strongly correlated with poor prognosis in breast cancer patients. However, the molecular mechanism by which DNAJB4 regulates...

Yanru Chen, **gjia Li, Lulan Pu, **ghua Hu, Lingyu Fang… in Discover Oncology (2023)

Article

SIK3-HDAC4 signaling pathway: the switch for transition between sleep and wakefulness

Yifei Tu, Fangfang Zhou, Long Zhang in Molecular Biomedicine (2023)

Article

Correction to: MicroRNA152-3p Protects Against Ischemia/Reperfusion-Induced Bbb Destruction Possibly Targeting the MAP3K2/JNK/c-Jun Pathway

Fei Li, Fangfang Zhou, Binbin Yang in Neurochemical Research (2023)

Article

Aprepitant inhibits the development and metastasis of gallbladder cancer via ROS and MAPK activation

Aprepitant, as a neurokinin-1 receptor (NK-1R) antagonist, originally applied for curing chemotherapy-induced nausea and vomiting, has been reported to have significant antitumor effect on several malignant tu...

Xueyan Cao, Yang Yang, Wei Zhou, Yue Wang, Xue Wang, **anxiu Ge, Fei Wang… in BMC Cancer (2023)

Article

Deciphering dynamic changes of the aging transcriptome with COVID-19 progression and convalescence in the human blood

Ran Li, **g Zou, Dongling Pei, Ting Pan… in Signal Transduction and Targeted Therapy (2023)

Article

Microglia regulate the health of central nervous system through myelin

**n Niu, Fangfang Zhou, Long Zhang in Molecular Biomedicine (2023)

Article

MicroRNA152-3p Protects Against Ischemia/Reperfusion-Induced Bbb Destruction Possibly Targeting the MAP3K2/JNK/c-Jun Pathway

In the current study, we reported that overexpression of miR-152-3p effectively ameliorated neurological deficits and protected blood-brain barrier(BBB) integrity in middle cerebral artery occlusion (MCAO) rat...

Fei Li, Fangfang Zhou, Binbin Yang in Neurochemical Research (2023)

Article

The loss of epigenetic information: not only consequences but a cause of mammalian aging

Chen Pan, Fangfang Zhou, Long Zhang in Signal Transduction and Targeted Therapy (2023)

Article

FXR inhibition: an innovative prophylactic strategy against SARS-CoV-2 infection

Zhe Li, Shuai Wang, Fangfang Zhou in Signal Transduction and Targeted Therapy (2023)

Article

Motile cilia and microvillar: accomplices of SARS-CoV-2 in penetrating mucus barrier and infecting airway epithelium

Peng Su, Fangfang Zhou, Long Zhang in Signal Transduction and Targeted Therapy (2023)