13 Result(s)
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Silvia Paola Caminiti
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Article
Open AccessHeterogeneity and overlap in the continuum of linguistic profile of logopenic and semantic variants of primary progressive aphasia: a Profile Analysis based on Multidimensional Scaling study
Primary progressive aphasia (PPA) diagnostic criteria underestimate the complex presentation of semantic (sv) and logopenic (lv) variants, in which symptoms partially overlap, and mixed clinical presentation (...
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Article
Open AccessSex differences in dementia with Lewy bodies: an imaging study of neurotransmission pathways
Dementia with Lewy bodies (DLB) is characterized by a wide clinical and biological heterogeneity, with sex differences reported in both clinical and pathologically confirmed DLB cohorts. No research evidence i...
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Open AccessIn vivo human molecular neuroimaging of dopaminergic vulnerability along the Alzheimer’s disease phases
Preclinical and pathology evidence suggests an involvement of brain dopamine (DA) circuitry in Alzheimer’s disease (AD). We in vivo investigated if, when, and in which target regions [123I]FP-CIT-SPECT regiona...
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Validation of FDG-PET datasets of normal controls for the extraction of SPM-based brain metabolism maps
An appropriate healthy control dataset is mandatory to achieve good performance in voxel-wise analyses. We aimed at evaluating [18F]FDG PET brain datasets of healthy controls (HC), based on publicly available ...
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Hypoglycemia-induced brain hypometabolism captured in real time by FDG-PET
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PET Neuroimaging in Dementia Conditions
In neurodegenerative diseases, several studies have increasingly highlighted that the same neuropathology can trigger different clinical phenotypes or, vice versa, that similar clinical phenotypes can be trigg...
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Article
Open AccessThe combined effects of microglia activation and brain glucose hypometabolism in early-onset Alzheimer’s disease
Early-onset Alzheimer’s disease (EOAD) is characterized by young age of onset (< 65 years), severe neurodegeneration, and rapid disease progression, thus differing significantly from typical late-onset Alzheim...
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Heterogeneous brain FDG-PET metabolic patterns in patients with C9orf72 mutation
The hexanucleotide repeat expansion in C9orf72 is an associated genetic cause in amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). In the “ALS/FTD” spectrum prevails clinical heterogeneity...
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Open AccessBrain glucose metabolism in Lewy body dementia: implications for diagnostic criteria
[18F]FDG-PET hypometabolism patterns are indicative of different neurodegenerative conditions, even from the earliest disease phase. This makes [18F]FDG-PET a valuable tool in the diagnostic workup of neurodeg...
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Article
Open AccessAltered brain metabolic connectivity at multiscale level in early Parkinson’s disease
To explore the effects of PD pathology on brain connectivity, we characterized with an emergent computational approach the brain metabolic connectome using [18F]FDG-PET in early idiopathic PD patients. We appl...
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Article
Validation of 18F–FDG-PET Single-Subject Optimized SPM Procedure with Different PET Scanners
18F–fluoro-deoxy-glucose Positron Emission Tomography (FDG-PET) allows early identification of neurodegeneration in dementia. The use of an optimized method based on the SPM software pack...
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Article
Cross-validation of biomarkers for the early differential diagnosis and prognosis of dementia in a clinical setting
The aim of this study was to evaluate the supportive role of molecular and structural biomarkers (CSF protein levels, FDG PET and MRI) in the early differential diagnosis of dementia in a large sample of patie...
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Erratum to: Cross-validation of biomarkers for the early differential diagnosis and prognosis of dementia in a clinical setting
