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Article
Left ventricle diastolic vortex ring characterization in ischemic cardiomyopathy: insight into atrio-ventricular interplay
Diastolic vortex ring (VR) plays a key role in the blood-pum** function exerted by the left ventricle (LV), with altered VR structures being associated with LV dysfunction. Herein, we sought to characterize ...
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Article
Open AccessAngulation and curvature of aortic landing zone affect implantation depth in transcatheter aortic valve implantation
In transcatheter aortic valve implantation (TAVI), final device position may be affected by device interaction with the whole aortic landing zone (LZ) extending to ascending aorta. We investigated the impact o...
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Article
Open AccessPath tracking control of a steerable catheter in transcatheter cardiology interventions
Intracardiac transcatheter interventions allow for reducing trauma and hospitalization stays as compared to standard surgery. In the treatment of mitral regurgitation, the most widely adopted transcatheter app...
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Article
A Deep Learning-Based and Fully Automated Pipeline for Thoracic Aorta Geometric Analysis and Planning for Endovascular Repair from Computed Tomography
Feasibility assessment and planning of thoracic endovascular aortic repair (TEVAR) require computed tomography (CT)-based analysis of geometric aortic features to identify adequate landing zones (LZs) for endo...
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Chapter and Conference Paper
Mixed Reality and Deep Learning for External Ventricular Drainage Placement: A Fast and Automatic Workflow for Emergency Treatments
The treatment of hydrocephalus is based on anatomical landmarks to guide the insertion of an External Ventricular Drain (EVD). This procedure can benefit from the adoption of Mixed Reality (MR) technology. In ...
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Article
Mathematical Modeling and Numerical Simulation of Atherosclerotic Plaque Progression Based on Fluid-Structure Interaction
In this work we propose a mathematical and numerical model to describe the early stages of atherosclerotic plaque formation, which is based on the interaction of processes with different spatial and temporal s...
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Article
Open AccessEx Vivo Model of Functional Mitral Regurgitation Using Deer Hearts
Transcatheter therapies are emerging for functional mitral regurgitation (FMR) treatment, however there is lack of pathological models for their preclinical assessment. We investigated the applicability of dee...
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Article
Hyperphysiological compression of articular cartilage induces an osteoarthritic phenotype in a cartilage-on-a-chip model
Owing to population aging, the social impact of osteoarthritis (OA)—the most common musculoskeletal disease—is expected to increase dramatically. Yet, therapy is still limited to palliative treatments or surgi...
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Article
Driving airway pressure: should we use a static measure to describe a dynamic phenomenon?
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Article
Open AccessLung anatomy, energy load, and ventilator-induced lung injury
High tidal volume can cause ventilator-induced lung injury (VILI), but positive end-expiratory pressure (PEEP) is thought to be protective. We aimed to find the volumetric VILI threshold and see whether PEEP i...
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Article
Open AccessAn anatomy-based lumped parameter model of cerebrospinal venous circulation: can an extracranial anatomical change impact intracranial hemodynamics?
The relationship between extracranial venous system abnormalities and central nervous system disorders has been recently theorized. In this paper we delve into this hypothesis by modeling the venous drainage i...
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Article
Functional and Biomechanical Effects of the Edge-to-Edge Repair in the Setting of Mitral Regurgitation: Consolidated Knowledge and Novel Tools to Gain Insight into Its Percutaneous Implementation
Mitral regurgitation is the most prevalent heart valve disease in the western population. When severe, it requires surgical treatment, repair being the preferred option. The edge-to-edge repair technique treat...
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Chapter
Repair of Mitral Valve Prolapse Through ePTFE Neochordae: A Finite Element Approach From CMR
Patient-specific finite element (FE) modeling is largely used to quantify mitral valve (MV) biomechanics associated to pathological and post-surgical conditions. We used this approach, integrated with non-inva...
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Chapter
The Principle: From a Computational Model to Clinical Validation
In the early phase of the clinical experience with the Alfieri technique, we were confronted with several unanswered questions in search for an urgent answer. While the technique seemed to be reliable and easy...
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Chapter
Finite Element Analysis of Transcatheter Aortic Valve Implantation in the Presence of Aortic Leaflet Calcifications
Transcatheter Aortic Valve (TAV) implantation is a recent interventional procedure for the replacement of the aortic valve in patients affected by severe aortic stenosis who are considered at high or prohibiti...
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Article
Intraoperative forces and moments analysis on patient head clamp during awake brain surgery
In brain surgery procedures, such as deep brain stimulation, drug-resistant epilepsy and tumour surgery, the patient is intentionally awakened to map functional neural bases via electrophysiological assessment...
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Article
Influence of Mitral Valve Anterior Leaflet in vivo Shape on Left Ventricular Ejection
Recent studies have demonstrated that, due to the active involvement of leaflet contractile elements, the anterior mitral leaflet (AML) is very stiff and maintains a compound curvature during ventricular systo...
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Article
Aortic Valve Repair via Neo-Chordae Technique: Mechanistic Insight Through Numerical Modelling
Recently, the neo-chordae technique (NCT) was proposed to stabilize the surgical correction of isolated aortic valve (AV) prolapse. Neo-chordae are inserted into the corrected leaflet to drive its closure by m...
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Article
Mitral Valve Patient-Specific Finite Element Modeling from Cardiac MRI: Application to an Annuloplasty Procedure
We aim at testing the possibility to build patient-specific structural finite element models (FEMs) of the mitral valve (MV) from cardiac magnetic resonance (CMR) imaging and to use them to predict the outcome...
