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  1. No Access

    Protocol

    Mechanical Induction of Osteoarthritis Traits in a Cartilage-on-a-Chip Model

    The present lack of effective therapies for osteoarthritis, the most diffused musculoskeletal disease, correlates with the absence of representative in vitro disease models. Microfabrication techniques and sof...

    Andrea Mainardi, Paola Occhetta, Marco Rasponi in Organ-on-a-Chip (2022)

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    Protocol

    Organ-on-Chips for Studying Tissue Barriers: Standard Techniques and a Novel Method for Including Porous Membranes Within Microfluidic Devices

    A relevant number of organ-on-chips is aimed at modeling epithelial/endothelial interfaces between tissue compartments. These barriers help tissue function either by protecting (e.g., endothelial blood–brain b...

    Mattia Ballerini, Mohammad Jouybar, Andrea Mainardi, Marco Rasponi… in Organ-on-a-Chip (2022)

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    Article

    Hyperphysiological compression of articular cartilage induces an osteoarthritic phenotype in a cartilage-on-a-chip model

    Owing to population aging, the social impact of osteoarthritis (OA)—the most common musculoskeletal disease—is expected to increase dramatically. Yet, therapy is still limited to palliative treatments or surgi...

    Paola Occhetta, Andrea Mainardi, Emiliano Votta… in Nature Biomedical Engineering (2019)