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Article
Genome-wide association study implicates immune activation of multiple integrin genes in inflammatory bowel disease
Jeffrey Barrett, Carl Anderson and colleagues report the results of a large genome-wide association study of inflammatory bowel disease. They identify 25 new genome-wide significant loci, 3 of which contain in...
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Article
Genetic determinants of ulcerative colitis include the ECM1 locus and five loci implicated in Crohn's disease
We report results of a nonsynonymous SNP scan for ulcerative colitis and identify a previously unknown susceptibility locus at ECM1. We also show that several risk loci are common to ulcerative colitis and Crohn'...
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Article
Sequence variants in the autophagy gene IRGM and multiple other replicating loci contribute to Crohn's disease susceptibility
A genome-wide association scan in individuals with Crohn's disease by the Wellcome Trust Case Control Consortium detected strong association at four novel loci. We tested 37 SNPs from these and other loci for ...
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Article
Defective meiosis in telomere-silencing mutants of Schizosaccharomyces pombe
During meiotic prophase, chromosomes frequently adopt a bouquet-like arrangement, with their telomeres clustered close to the nuclear periphery1,2,3. A dramatic example of this occurs in the fission yeast, Schizo...
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Article
Regulation of telomere length and function by a Myb-domain protein in fission yeast
Telomeres, the specialized nucleoprotein structures that comprise the ends of eukaryotic chromosomes1,2, are essential for complete replication3–5, and regulation of their length has been a focus of research on t...
