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Article
Proteasome-dependent truncation of the negative heterochromatin regulator Epe1 mediates antifungal resistance
Epe1 histone demethylase restricts H3K9-methylation-dependent heterochromatin, preventing it from spreading over, and silencing, gene-containing regions in fission yeast. External stress induces an adaptive re...
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Article
Epigenetic gene silencing by heterochromatin primes fungal resistance
Heterochromatin that depends on histone H3 lysine 9 methylation (H3K9me) renders embedded genes transcriptionally silent1–3. In the fission yeast Schizosaccharomyces pombe, H3K9me heterochromatin can be transmitt...
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Article
Open AccessInterspecies conservation of organisation and function between nonhomologous regional centromeres
Despite the conserved essential function of centromeres, centromeric DNA itself is not conserved. The histone-H3 variant, CENP-A, is the epigenetic mark that specifies centromere identity. Paradoxically, CENP-...
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Article
Kinetochore and heterochromatin domains of the fission yeast centromere
Fission yeast centromeres are composed of two distinctive chromatin domains. The central domain nucleosomes contain the histone H3-like protein CENP-ACnp1. In contrast, the flanking repeats are coated with silent...
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Article
Defective meiosis in telomere-silencing mutants of Schizosaccharomyces pombe
During meiotic prophase, chromosomes frequently adopt a bouquet-like arrangement, with their telomeres clustered close to the nuclear periphery1,2,3. A dramatic example of this occurs in the fission yeast, Schizo...
