21 Result(s)

Article

Involvement of the Mitochondrial Ca²⁺-Independent Phospholipase iPLA2 in the Induction of Mitochondrial Permeability Transition Pore by Long-Chain Acylcarnitines

It is known that activated derivatives of long-chain fatty acids acylcarnitines (LCAC) are considered the most toxic, which, along with calcium, can participate in the induction of the mitochondrial pore, invo...

N. I. Fedotcheva, E. V. Grishina… in Biochemistry (Moscow), Supplement Series A… (2023)

Article

Induction of Mitochondrial Cyclosporin-Dependent Permeability Transition Pore by Acylcarnitines. Effects of Concentrations and Carbon Chain Length

It is known that the concentrations of long-chain fatty acids (LCFA) and their carnitine derivatives (LCAC) in obesity and diabetes greatly increase, and under conditions of ischemia-reperfusion can exceed ten...

N. I. Fedotcheva, E. V. Grishina… in Biochemistry (Moscow), Supplement Series A… (2022)

Article

The Effects of L-Arginine and Nitric Oxide Donors on the Induction of Mitochondrial Permeability Transition Pore by Calcium Ions and Palmitoylcarnitine. Possible Involvement of Mitochondrial NO/cGMP/PKG Signaling System

This study was focused on the mechanisms of the protective effects of L-arginine and the nitric oxide donor SNAP under the induction of cyclosporine A-dependent mitochondrial permeability transition pore (MPTP) b...

V. V. Dynnik, E. V. Grishina… in Biochemistry (Moscow), Supplement Series A… (2021)

Article

Implication of Mitochondrial NO/cGMP/PKG Signaling System in the Activation and Inhibition of Mitochondrial Respiration by L-Arginine and NO Donors

The involvement of the mitochondrial calcium-dependent NO synthase (mtNOS) in the regulation of mitochondrial respiration has not been sufficiently studied. Moreover, the possible functioning of a mitochondria...

V. V. Dynnik, E. V. Grishina… in Biochemistry (Moscow), Supplement Series A… (2019)

Article

Emergence of acetylcholine resistance and loss of rhythmic activity associated with the development of hypertension, obesity, and type 2 diabetes

The aim of this work was to study the influence of aging, obesity, metabolic syndrome (MS), hypertension (HT), and type 2 diabetes (T2D) on the endogenous rhythmic activity and the development acetylcholine re...

L. A. Andreeva, E. V. Grishina… in Biochemistry (Moscow) Supplement Series A:… (2016)

Article

Induction of cyclosporine-sensitive mitochondrial permeability transition pore by substrates forming acetyl-CoA under normal conditions and in type 2 diabetes

Oxidation of pyruvate and palmitoylcarnitine in mitochondria is accompanied by the formation of acetyl-CoA, with its possible participation in the acetylation of various proteins and enzymes that may lead to t...

E. V. Grishina, M. H. Galimova… in Biochemistry (Moscow) Supplement Series A:… (2016)

Article

Age-related peculiarities of succinate effect on induced lipid peroxidation in rat liver mitochondria

The antioxidant effect of succinate and 3-hydroxybutyrate oxidation on the kinetics of lipid peroxidation induced by ATP—Fe²⁺ complex in isolated rat liver mitochondria of old (1–1.5 years) and young (3 months) m...

E. V. Grishina, Ya. V. Khaustova, A. A. Vasilieva, E. I. Mayevsky in Biophysics (2015)

Article

The role of energy substrates in the regulation of force-frequency relationship in the rat myocardium: the influence of ambiocor

The effect of ambiocor (15 mg/100 ml), which contains natural substrates of energy metabolism, on the contractility of papillary muscle of the right ventricle of rat heart was studied at stimulation frequencie...

O. V. Nakipova, A. S. Averin, N. M. Zakharova, M. L. Uchitel, E. V. Grishina… in Biophysics (2010)

Article

Inhibition of Ca-induced calcium release from mitochondria by antiischemic phenol-based antioxidants

Effects of different inhibitors of lipid peroxidation (LP), such as sulphur-containing oligoquinone hypoxen, natural flavonoid dihydroquercetin (DHQ), and β-ionol, on Ca²⁺-induced calcium release from rat liver m...

E. V. Grishina, Y. V. Khaustova… in Biochemistry (Moscow) Supplement Series A:… (2009)

Article

Accelerated utilization of lactate under the effect of hypoxen after intensive exercise

Administration of substrates of energy metabolism in combination with hypoxen (sulfur-containing oligoquinone) promoted the increase in blood lactate concentration during maximum exercise, accelerated lactate ...

E. V. Grishina, Ya. V. Khaustova… in Bulletin of Experimental Biology and Medic… (2008)

Article

Glucose Metabolism in Healthy Subjects and in Patients with Carbohydrate and Lipid Metabolic Disorders

The rate of glucose oxidation was studied by measurement of the ¹³C concentration in expired air with simultaneous detection of the activity of the pyruvate dehydrogenase complex in subjects with obesity and pati...

E. I. Sokolov, A. L. Davydov, N. T. Starkova, A. M. Zyakun… in Human Physiology (2002)

Article

Interactions between the genetic transfer-inhibiting systems finU and finV in polyplasmid complexes ofEscherichia coli K-12 cells

The inhibition of conjugative transfer of derepressed plasmids was appreciably increased in polyplasmid complexes ofEscherichia coli K-12 cells containing two repressed conjugative plasmids with the finV system o...

E. V. Grishina, V. P. Shchipkov… in Bulletin of Experimental Biology and Medic… (1995)

Article

Chromosomal genes ofE. coli and activity of the fin V genetic system in plasmid transfer regulation

N. I. Buyanova, E. V. Grishina, A. P. Pekhov in Bulletin of Experimental Biology and Medic… (1993)

Article

Genetic regulation of conjugative properties of pAP18 plasmid complex inE.coli

E. V. Grishina, V. P. Shchipkov… in Bulletin of Experimental Biology and Medic… (1993)

Article

Incompatibility and replication of plasmids

E. V. Grishina, A. P. Pekhov in Bulletin of Experimental Biology and Medicine (1991)

Article

Cointegration between F-like conjugative plasmids

E. V. Grishina, A. P. Pekhov in Bulletin of Experimental Biology and Medicine (1991)

Article

Phospholipase A₂ activity determines rate of mitochondrial respiration in hibernating animals

N. N. Brustovetskii, E. V. Grishina… in Bulletin of Experimental Biology and Medic… (1989)

Article

Antiviral activity of organosilicon compounds with an adamantyl substituent

E. V. Grishina, N. S. Fedotov, V. D. Sheludyakov… in Pharmaceutical Chemistry Journal (1988)

Article

Depression of neuron responses to acetylcholine by combined application of norepinephrine and substrates of the tricarboxylic acid cycle

1. The possible relationship between the function of nicotinic acetylcholine receptors inLymnaea stagnalis neuro...

A. A. Andreev, C. A. Vulfius, A. Yu. Budantsev… in Cellular and Molecular Neurobiology (1986)

Article

Preparation of 6-styrylphenanthridines

(6-Phenanthridinylmethyl)magnesium halides do not react with aromatic and aliphatic aromatic ketones but do react with aromatic aldehydes to give the corresponding carbinols. The latter are readily dehydrated ...

E. V. Grishina, é. R. Zakhs, V. P. Martynova in Chemistry of Heterocyclic Compounds (1974)