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Article
Deep Hypothermia Inverts the Inotropic Effect of Isoproterenol in the Rat Myocardium
The effects of the β-adrenergic receptor agonist isoproterenol on the contractile activity of the papillary muscle of the rat heart right ventricle were studied both at a temperature close to physiological (30...
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Article
Muscarinic and Nicotinic Acetylcholine Receptors in the Regulation of the Cardiovascular System
Many different receptors and ion channels that regulate ion currents are involved in the control of the cardiovascular system (CVS). The functioning of the CVS occurs with the involvement of the processes of n...
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Article
Effects of Nickel Chloride on Myocardial Contractile Properties in Active Ground Squirrels with Different Responses to Hypothermia
The effects of 1.5 mM nickel chloride on the contraction force, the force–frequency relation, and post-rest potentiation in the myocardium were studied in active Urocitellus undulates ground squirrels with differ...
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Article
Restoration of Vital Functions in Rats after Clinical Death Caused by Cold Water Submersion
Abstract—The permissible time limits have been investigated at which self-restoration of life functions is possible in rats after being in a state of clinical death under ultra-deep hypothermia at temperatures be...
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Article
The Effect of the Extracellular Ca2+ Concentration on the Force–Frequency Dependence in the Myocardium of the Guinea Pig: Potentiation by a Pause under Pronounced Hypothermia
Abstract—The effects of a four-fold decrease in the concentration of Ca2+ in a perfusing medium under pronounced hypothermia at 20°C on the contractile responses of the papillary muscles of the right ventricle of...
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Article
Effect of Cooling on Force-Frequency Relationship, Rest Potentiation, and Frequency-Dependent Acceleration of Relaxation in the Guinea Pig Myocardium
While deep hypothermia is well known to lead to cardiac malfunction up to circulatory arrest, mild hypothermia can prevent hypoxic damage to the heart. Importantly, a large body of research on deep hypothermia...
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Article
The Condition of the Rat Myocardium and Isolated Sheep Heart after Prolonged 24-Hour Hypothermic Preservation in a Pressurized Carbon Monoxide–Oxygen Gas Mixture
High organoprotective properties of a carbon monoxide (CO)–oxygen (O2) gas mixture were confirmed after prolonged (24-h) preservation of the papillary muscle and an isolated rat heart at 4°C. Hypothermic preserva...
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Article
Activation of Sarcolemmal α2 Adrenoceptors Supports Са2+ Homeostasis and Prevents Ventricular Arrhythmia under Sympathetic Stress
Abstract—The body’s response to stress is mediated by the interaction of catecholamines with adrenergic α- and β-receptors. It has been established that, in contrast to α1- and β-adrenoceptors, α2-adrenoceptors a...
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Article
The Force-Frequency Dependence in the Heart Papillary Muscle of Ground Squirrel as a Reflection of Changes in the Functional State of Animals during the Annual Cycle
Abstract—A study was conducted to explore the characteristics of the dependence of the contraction force (isometric mode at 30°C) on the frequency of stimulation (0.1–4.0 Hz) in the right ventricle papillary musc...
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Article
Myocardial α2-Adrenoceptors as Therapeutic Targets to Prevent Cardiac Hypertrophy and Heart Failure
Abstract—Aberrations in mechanisms of cardiac adaptation to catecholamine overflow can result in maladaptive cardiac hypertrophy and heart failure. Currently available heart failure therapies fall short of expect...
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Article
Cardiotoxins from Cobra Naja oxiana Change the Force of Contraction and the Character of Rhythmoinotropic Phenomena in the Rat Myocardium
The study of the influence of cobra Naja oxiana cardiotoxins on the contractility of the rat papillary muscles and its rhythmoinotropic characteristics has shown that the presence of toxins induces a slight contr...
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Article
The effects of KB-R7943, an inhibitor of reverse Na+/Ca2+ exchange, on the force of contraction of papillary muscles in the heart of the ground squirrel Spermophilus undulatus
We investigated the effect of KB-R7943, an inhibitor of the reverse mode of Na+/Ca2+ exchanger, on the force of isometric contractions, the contractile force–frequency relationship and post-rest potentiation (a q...
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Article
The effect of agmatine on the rhythmoinotropic properties of the cardiac papillary muscle of hibernating animals
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Article
The role of energy substrates in the regulation of force-frequency relationship in the rat myocardium: the influence of ambiocor
The effect of ambiocor (15 mg/100 ml), which contains natural substrates of energy metabolism, on the contractility of papillary muscle of the right ventricle of rat heart was studied at stimulation frequencie...
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Article
Isoproterenol effects on the contractility of papillary muscles in the heart of ground squirrel
This paper presents a study of the influence of isoproterenol (1 μM) on the force of isometric contractions (0.1–1.0 Hz; 30 ± 1°C; 1.8 mM Ca2+) of papillary muscles of the right ventricle in the heart of a ground...
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Article
Changes in force-frequency relationships in cardiac papillary muscles of hibernating ground squirrels under cooling
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Article
Photon radiation-induced structural and functional changes in the myocardium of hypertensive spontaneously hypertensive rats
Hypertensive SHR rates were irradiated with orange-red light using a Korobkov photon light-emitting diode matrix with a maximum radiation at 612 nm; irradiation was performed daily for 1 h for 13 days. After t...
