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Article
Open AccessA Systematic Review of Methods and Practice for Integrating Maternal, Fetal, and Child Health Outcomes, and Family Spillover Effects into Cost-Utility Analyses
Maternal-perinatal interventions delivered during pregnancy or childbirth have unique characteristics that impact the health-related quality of life (HRQoL) of the mother, fetus, and newborn child. However, ma...
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Article
Open AccessA Systematic Review of Methods Used by Pediatric Cost-Utility Analyses to Include Family Spillover Effects
A child’s health condition affects family members’ health and well-being. However, pediatric cost-utility analysis (CUA) commonly ignores these family spillover effects leading to an incomplete understanding o...
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Article
Pediatric Multiple Sclerosis: Changing the Trajectory of Progression
Multiple sclerosis is a chronic inflammatory disease of the central nervous system. When seen in children and adolescents, crucial stages of brain development and maturation may be affected. Prompt recognition...
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Article
SARS-CoV-2 infection in technology-dependent children: a multicenter case series
The objective of this study was to describe the clinical course and outcomes in children with technology dependence (TD) hospitalized with SARS-CoV-2 infection.
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Chapter
Immunvermittelte Enzephalitiden
Enzephalitis war in Kanada zwischen 1994 und 2008 für 5,2 Krankenhausaufenthalte bei 100.000 Einwohnern verantwortlich. Während 50 % dieser Fälle zu diesem Zeitpunkt unbekannte Ätiologien hatten, wurde kürzlic...
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Chapter
Neuroinflammatorische und demyelinisierende Erkrankungen des Kindesalters
In diesem Kapitel werden wir monophasische und rezidivierende demyelinisierende Störungen bei Kindern untersuchen. Wir werden zunächst die Konsensdefinitionen überprüfen und einen Ansatz für die Bewertung von ...
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Chapter
Immune-Mediated Encephalidities
Encephalitis accounted for hospitalizations in 5.2/100,000 population between 1994 and 2008 in Canada [1]. While 50% of these cases had unknown etiologies at the time [1], it has recently become clear that a l...
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Chapter
Neuroinflammatory and Demyelinating Disorders of Childhood
In this chapter, we will review monophasic and recurrent demyelinating disorders in children. We will first review consensus definitions and provide an approach to the evaluation of children with first episode...
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Article
Improving Outcomes in Pediatric Multiple Sclerosis: Current and Emerging Treatments
Pediatric-onset multiple sclerosis (MS) comprises 2–5% of MS cases, and is known to be associated with high disease activity and the accumulation of disability at an earlier age than their adult-onset counterp...
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Article
Author Correction: Neuroimmune disorders of the central nervous system in children in the molecular era
In the original version of this Review published online and in print, the contribution of attendees of the International Neuroimmune Meeting to the content of the Review was not acknowledged. The author list h...
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Article
Neuroimmune disorders of the central nervous system in children in the molecular era
Immune-mediated disorders of the CNS in children are a complex group of demyelinating, inflammatory, parainfectious and postinfectious disorders with heterogeneous pathobiological mechanisms and clinical manif...
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Article
Acute Flaccid Paralysis and Enteroviral Infections
The focus of this review is on enterovirus (EV)-associated acute flaccid paralysis (AFP) due to spinal cord anterior horn cell disease. Emphasis is placed on the epidemiology, pathogenesis, diagnosis, treatmen...
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Article
Correction to: Impact of an electronic monitoring device and behavioural feedback on adherence to multiple sclerosis therapies in youth: results of a randomized trial
The clinicaltrials.gov identifying number for the article titled “Impact of an electronic monitoring device and behavioral feedback on adherence to multiple sclerosis therapies in youth: results of a randomize...
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Article
Impact of an electronic monitoring device and behavioral feedback on adherence to multiple sclerosis therapies in youth: results of a randomized trial
To report the results of a randomized controlled trial using an electronic monitoring device (EM) plus a motivational interviewing (MI) intervention to enhance adherence to disease-modifying therapies (DMT) in...
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Chapter
15th International Congress on Antiphospholipid Antibodies Task Force on Pediatric Antiphospholipid Syndrome Report
In preparation to the 15th International Congress on Antiphospholipid Antibodies (aPL), a multidisciplinary pediatric antiphospholipid syndrome (APS) task force was created in order to review the accumulated k...
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Article
Open AccessROHHAD syndrome and evolution of sleep disordered breathing
Rapid-onset obesity with hypothalamic dysfunction, hypoventilation and autonomic dysregulation (ROHHAD) is a rare disease with a high mortality rate. Although nocturnal hypoventilation (NH) is central to ROHHA...
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Article
Which MRI findings predict MS development in children?
MRI-based diagnostic criteria for multiple sclerosis (MS) have been devised for use in adult populations, but diagnosis of MS in children remains a challenge. To address this issue, a new study attempts to ide...
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Chapter
Acuted Disseminated Encephalomyelitis
Acute disseminated encephalomyelitis (ADEM) is a disorder of the central nervous system (CNS) characterized by an acute event, typically with encephalopathy, in which diffuse CNS involvement occurs. It may fol...
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Article
Fingolimod: an oral disease-modifying therapy for relapsing multiple sclerosis
This paper presents a summary of the current knowledge of the mechanism of action of fingolimod (FTY720; Gilenya®; Novartis Pharma Stein AG, Stein, Switzerland) and the phase 2 and 3 studies that have been per...
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Article
Pediatric multiple sclerosis
Despite its relative rarity, pediatric multiple sclerosis (MS) is an important entity, as it provides unique insights into disease processes related to MS. Clinical, MRI and laboratory data suggest differences...
