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15th International Congress on Antiphospholipid Antibodies Task Force on Pediatric Antiphospholipid Syndrome Report

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Antiphospholipid Syndrome

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Abstract

In preparation to the 15th International Congress on Antiphospholipid Antibodies (aPL), a multidisciplinary pediatric antiphospholipid syndrome (APS) task force was created in order to review the accumulated knowledge of the pediatric APS (pathogenesis, clinical and laboratory features, diagnosis, classification, and treatment), assess modifications to the APS classification criteria (applicability to children and neonates), and make recommendations for future research. This report covers a brief review of hemostasis including vessel damage and platelet response (adhesion, activation, and aggregation); thrombin generation in the cell-based model of coagulation, fibrinolysis (clot dissolution), and modulation; and hemostasis measurement. There follows a discussion of developmental hemostasis (highlighting the differences between children and adults), thrombosis risk assessment (genetic and extrinsic), clinical and laboratory features of APS in children, prevention and treatment of APS in children, and long-term follow-up of children born to mothers with aPL. The report concludes with acknowledgment of the progress made to date in literature reviews, surveys of practice patterns, refinement of registry data entry, and the need for published proposals for revised classification criteria. Studies including validation of proposed criteria, evaluation of therapies (especially the newer agents), and development and testing of risk stratification models by patient age still need to be performed.

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Acknowledgments

The authors would like to thank Cecilia Nalli, Angela Tincani, and Elisa Fazzi at the University of Brescia, Italy, for their guidance and advice.

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Authors and Affiliations

  1. Pediatric Rheumatology, Children’s Hospital of University of Illinois, Chicago, IL, USA

    Arzu Soybilgic

  2. Pediatric Rheumatology, Children’s Hospital of The King’s Daughters, Eastern Virginia Medical School, Norfolk, VA, USA

    Cassyanne L. Aguiar

  3. Department of Pediatrics, University of Alberta, Stollery Children’s Hospital, Edmonton, Alberta, Canada

    M. Patricia Massicotte

  4. Sheba Medical Center at Tel Hashomer, Ramat-Gan, Tel Aviv, Israel

    Gili Kenet

  5. Division of Neurology, Department of Pediatrics, Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada

    E. Ann Yeh

  6. Department of Clinical and Experimental Sciences, Unit of Rheumatology and Clinical Immunology, Spedali Civili di Brescia, University of Brescia, Brescia, Italy

    Laura Andreoli

  7. Children’s Hospital, University Medical Center Ljubljana; and Faculty of Medicine University of Ljubljana, Department of Allergology, Rheumatology and Clinical Immunology, Ljubljana, Slovenia

    Tadej Avcin

  8. Pediatric Rheumatology, Sugar Land, TX, USA

    Barry L. Myones

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  1. Arzu Soybilgic
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  3. M. Patricia Massicotte
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  8. Barry L. Myones
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Correspondence to Barry L. Myones .

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Editors and Affiliations

  1. The Barbara Volcker Center for Women and Rheumatic Diseases, Associate Attending Physician, Hospital for Special Surgery, Associate Professor of Medicine, Weill Cornell Medicine, New York, New York, USA

    Doruk Erkan

  2. The Barbara Volcker Center for Women and Rheumatic Diseases, Attending Physician, Hospital for Special Surgery, Professor of Medicine and Obstetrics-Gynecology, Weill Cornell Medicine, New York, New York, USA

    Michael D. Lockshin

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Soybilgic, A. et al. (2017). 15th International Congress on Antiphospholipid Antibodies Task Force on Pediatric Antiphospholipid Syndrome Report. In: Erkan, D., Lockshin, M. (eds) Antiphospholipid Syndrome. Springer, Cham. https://doi.org/10.1007/978-3-319-55442-6_16

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  • DOI: https://doi.org/10.1007/978-3-319-55442-6_16

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-55440-2

  • Online ISBN: 978-3-319-55442-6

  • eBook Packages: MedicineMedicine (R0)

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