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Open AccessInflammatory and neurodegenerative serum protein biomarkers increase sensitivity to detect clinical and radiographic disease activity in multiple sclerosis
The multifaceted nature of multiple sclerosis requires quantitative biomarkers that can provide insights related to diverse physiological pathways. To this end, proteomic analysis of deeply-phenotyped serum sa...
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Article
Open AccessIdentification and management of subclinical disease activity in early multiple sclerosis: a review
Early treatment initiation in multiple sclerosis (MS) is crucial in preventing irreversible neurological damage and disability progression. The current assessment of disease activity relies on relapse rates an...
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Article
Open AccessCorrection to: Clinical trial-ready patient cohorts for multiple system atrophy: coupling biospecimen and iPSC banking to longitudinal deep-phenoty**
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Article
Open AccessClinical Trial-Ready Patient Cohorts for Multiple System Atrophy: Coupling Biospecimen and iPSC Banking to Longitudinal Deep-Phenoty**
Multiple system atrophy (MSA) is a fatal neurodegenerative disease of unknown etiology characterized by widespread aggregation of the protein alpha-synuclein in neurons and glia. Its orphan status, biological ...
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Article
Multiple sclerosis lesions that impair memory map to a connected memory circuit
Nearly 1 million Americans are living with multiple sclerosis (MS) and 30–50% will experience memory dysfunction. It remains unclear whether this memory dysfunction is due to overall white matter lesion burden...
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Open AccessEarly miR-320b and miR-25-3p miRNA levels correlate with multiple sclerosis severity at 10 years: a cohort study
Multiple sclerosis (MS) is a chronic demyelinating autoimmune disorder which may cause long-term disability. MicroRNA (miRNA) are stable, non-coding molecules that have been identified in our Comprehensive Lon...
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Open AccessmiRNA 548a-3p as biomarker of NEDA-3 at 2 years in multiple sclerosis patients treated with fingolimod
Multiple sclerosis (MS) is a disabling autoimmune demyelinating disorder affecting young people and causing significant disability. In the last decade, different microRNA (miRNA) expression patterns have been ...
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Article
Lesion network localization of depression in multiple sclerosis
Multiple sclerosis (MS), a demyelinating disease that causes focal white matter lesions, is commonly associated with depression. However, it remains unclear whether depression risk is selectively increased by ...
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Article
Open AccessSymptom Interconnectivity in Multiple Sclerosis: A Narrative Review of Potential Underlying Biological Disease Processes
Fatigue, cognitive impairment, depression, and pain are highly prevalent symptoms in multiple sclerosis (MS). These often co-occur and may be explained by a common etiology. By reviewing existing literature, w...
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Article
Open AccessComparison of dimethyl fumarate and interferon outcomes in an MS cohort
To compare the effectiveness of dimethyl fumarate (DMF) with subcutaneous interferon beta-1a (IFNβ-1a) in controlling disease activity in patients with relapsing–remitting Multiple Sclerosis (MS).
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Article
Open AccessDissection of multiple sclerosis genetics identifies B and CD4+ T cells as driver cell subsets
Multiple sclerosis (MS) is an autoimmune condition of the central nervous system with a well-characterized genetic background. Prior analyses of MS genetics have identified broad enrichments across peripheral ...
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Article
Patient-reported outcomes associated with transition to secondary progressive multiple sclerosis
To investigate patient-reported outcome (PRO) measures in patients with relapsing–remitting multiple sclerosis (RRMS) who transition to secondary progressive multiple sclerosis (SPMS).
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Article
Author Correction: Pan-viral serology implicates enteroviruses in acute flaccid myelitis
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Clinical Approach to Pediatric Demyelinating Disease
Demyelinating events in pediatric patients encompass a broad and heterogeneous group of disorders with variable pathophysiology. Differentiating disorders can be complex but has sizeable implications with rega...
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Article
Open AccessAuthor Correction: Ensemble learning predicts multiple sclerosis disease course in the SUMMIT study
A correction to this paper has been published: https://doi.org/10.1038/s41746-020-00361-9.
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Open AccessEnsemble learning predicts multiple sclerosis disease course in the SUMMIT study
The rate of disability accumulation varies across multiple sclerosis (MS) patients. Machine learning techniques may offer more powerful means to predict disease course in MS patients. In our study, 724 patient...
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Open AccessIdentification of TNFAIP3 as relapse biomarker and potential therapeutic target for MOG antibody associated diseases
MOG-antibody associated disease (MOG-AAD) is a recently recognized demyelinating disorder predominantly affecting children but also occurs in adults, with a relapsing course in approximately 50% of patients. W...
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Open AccessCorrection to: Long-Term Effect of Immediate Versus Delayed Fingolimod Treatment in Young Adult Patients with Relapsing–Remitting Multiple Sclerosis: Pooled Analysis from the FREEDOMS/FREEDOMSII Trials
Figures 1a, 1b and 3 were published incorrectly in the original version. The corrected images are given as follows.
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Neuromyelitis optica spectrum disorders and pregnancy: therapeutic considerations
Neuromyelitis optica spectrum disorders (NMOSD) are a type of neurological autoimmune disease characterized by attacks of CNS inflammation that are often severe and predominantly affect the spinal cord and opt...
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Article
Open AccessQuantifying neurologic disease using biosensor measurements in-clinic and in free-living settings in multiple sclerosis
Technological advances in passive digital phenoty** present the opportunity to quantify neurological diseases using new approaches that may complement clinical assessments. Here, we studied multiple sclerosi...
